General Information of the Compound
Compound ID
CP0023355
Compound Name
1-[4-[(4-ethylpyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)phenyl]ethanone
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Structure
Formula
C26H28N2O2
Molecular Weight
400.522
Canonical SMILES
CCc1ccnc(COc2ccc(cc2-c2ccc3CCNCCc3c2)C(C)=O)c1
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InChI
InChI=1S/C26H28N2O2/c1-3-19-8-13-28-24(14-19)17-30-26-7-6-21(18(2)29)16-25(26)23-5-4-20-9-11-27-12-10-22(20)15-23/h4-8,13-16,27H,3,9-12,17H2,1-2H3
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InChIKey
LYMYUDCINDYGMQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.7808
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
51.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70665412
ChEMBL ID
CHEMBL4282883
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01441, Tyrosine-protein kinase SYK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
IC50 = 251.19 nM
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