General Information of the Compound
Compound ID
CP0131477
Compound Name
methyl 4-[[3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzoyl]amino]benzoate
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Structure
Formula
C29H25N5O5
Molecular Weight
523.549
Canonical SMILES
COC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cn3ccnc3c(Nc3ccc(OC)c(OC)c3)n2)cc1
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InChI
InChI=1S/C29H25N5O5/c1-37-24-12-11-22(16-25(24)38-2)31-26-27-30-13-14-34(27)17-23(33-26)19-5-4-6-20(15-19)28(35)32-21-9-7-18(8-10-21)29(36)39-3/h4-17H,1-3H3,(H,31,33)(H,32,35)
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InChIKey
YOPAYVFARYKQBD-UHFFFAOYSA-N
Physicochemical Property
logP
5.196
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
116.08
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44187114
SID: 85182779
ChEMBL ID
CHEMBL3264996
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01441, Tyrosine-protein kinase SYK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
EC50 = 293 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15.2 nM