Brief Information of the Compound and Protein
Compound Name
6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Show/Hide
PubChem ID
CID: 118161062
Canonical SMILES
Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
    Show/Hide
Compound Formula C23H25N9O
Compound Structure
Protein Name
Tyrosine-protein kinase SYK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Syk family
Uniprot ID
P43405
Gene Name
SYK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 90 nM
2 EC50 = 180 nM
3 EC50 = 700 nM
4 IC50 = 6.2 nM