Brief Information of the Compound and Protein
Compound Name
 Compound Info 
BDBM50249542
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 PubChem ID
CID: 11213558
SID: 16296087
Canonical SMILES
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
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Compound Formula C22H23FN6O5
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase SYK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Syk family
Uniprot ID
P43405
Gene Name
SYK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 53 nM
   TI
   LI
   LO
   TS
2
IC50 = 457 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 171 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 111 nM
2 IC50 = 5.5 nM
3 IC50 = 23.62 nM
4 IC50 = 41 nM
5 IC50 = 64 nM
6 IC50 = 68 nM
7 Kd = 19 nM
8 Ki = 30 nM