General Information of the Compound
Compound ID
CP0948350
Compound Name
N-(4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
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Structure
Formula
C25H23N7O
Molecular Weight
437.507
Canonical SMILES
c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4C[C@H]5CC[C@@H](C4)O5)cc3)c2n1
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InChI
InChI=1S/C25H23N7O/c1-2-17-12-27-30-22(17)11-16(1)23-15-31-10-9-26-25(31)24(29-23)28-18-3-5-19(6-4-18)32-13-20-7-8-21(14-32)33-20/h1-6,9-12,15,20-21H,7-8,13-14H2,(H,27,30)(H,28,29)/t20-,21+
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InChIKey
UBDJWLDNVBIAMQ-OYRHEFFESA-N
Physicochemical Property
logP
4.3838
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
83.37
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156014856
ChEMBL ID
CHEMBL4640287
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01441, Tyrosine-protein kinase SYK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
EC50 = 162 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5.3 nM