General Information of the Compound
Compound ID
CP0368580
Compound Name
1-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]piperidin-4-ol
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Structure
Formula
C24H23N7O
Molecular Weight
425.496
Canonical SMILES
OC1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
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InChI
InChI=1S/C24H23N7O/c32-20-7-10-30(11-8-20)19-5-3-18(4-6-19)27-23-24-25-9-12-31(24)15-22(28-23)16-1-2-17-14-26-29-21(17)13-16/h1-6,9,12-15,20,32H,7-8,10-11H2,(H,26,29)(H,27,28)
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InChIKey
LHWYLUXBRGSQTB-UHFFFAOYSA-N
Physicochemical Property
logP
3.9773
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
94.37
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59473526
ChEMBL ID
CHEMBL4647927
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01441, Tyrosine-protein kinase SYK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.2 nM