General Information of the Cell Line
Cell Line ID
CL000743
Cell Line Name
CellSensor STAT6-bla RA-1
Synonyms
STAT6-bla RA-1
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_KS55
Tissue Information
Ascites
Disease
Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01659, Tyrosine-protein kinase JAK1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0692982
 Compound Info 
[(1R,2R,4R,5S)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
   Show/Hide
C16H18N4O
  1
1
IC50 = 77 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002393
 Compound Info 
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
   Show/Hide
C16H20N6O
  1
1
IC50 = 87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701646
 Compound Info 
rac-3-Methyl-4-[trans-4-[2-oxo-2-(3-phenylpyrrolidin-1-yl)-ethyl]cyclohexyl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C25H30N4O2
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0812653
 Compound Info 
4-[trans-4-[2-(4,4-Dimethyl-1-piperidyl)-2-oxo-ethyl]-cyclohexyl]-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C22H32N4O2
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0640933
 Compound Info 
ABROCITINIB
   Show/Hide
C14H21N5O2S
  1
1
IC50 = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0712228
 Compound Info 
4-[trans-4-[2-(3-Benzylazetidin-1-yl)-2-oxo-ethyl]-cyclohexyl]-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C25H30N4O2
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701645
 Compound Info 
[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl] (1S)-2,2-difluorocyclopropanecarboxylate
   Show/Hide
C17H19F2N3O3
  1
1
IC50 = 420 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0692981
 Compound Info 
[(1S,2S,4S,5R)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
   Show/Hide
C16H18N4O
  1
1
IC50 = 770 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701648
 Compound Info 
rac-3-Methyl-4-[(1R*,2S*,4S*)-norbornan-2-yl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C14H17N3O
  1
1
IC50 = 850 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701641
 Compound Info 
rac-4-(2-Bicyclo[2.2.2]octanyl)-3-methyl-2,7-dihydropyrazolo-[3,4-b]pyridin-6-one
   Show/Hide
C15H19N3O
  1
1
IC50 = 890 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701647
 Compound Info 
rac-3-Methyl-4-[(1R*,2R*,4S*)-norbornan-2-yl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C14H17N3O
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0692984
 Compound Info 
2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetonitrile
   Show/Hide
C15H18N4O
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0693222
 Compound Info 
3-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]propanenitrile
   Show/Hide
C16H20N4O
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0768026
 Compound Info 
[(1S,2R,4S,5R)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
   Show/Hide
C16H18N4O
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0692983
 Compound Info 
rac-3-Methyl-4-[(1S*,2R*)-2-methylcyclohexyl]-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C14H19N3O
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0692980
 Compound Info 
(1S)-2,2-Difluoro-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-cyclopropanecarboxamide
   Show/Hide
C17H20F2N4O2
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0162853
 Compound Info 
4-cyclohexyl-3-cyclopropyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C15H19N3O
  1
1
IC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0207734
 Compound Info 
4-cyclohexyl-3-ethyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C14H19N3O
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701643
 Compound Info 
[(1R,2S,4R,5S)-5-(3-Methyl-6-oxo-1,2,7-triaza-2,7-dihydroinden-4-yl)-2-norbornanyl]acetonitrile
   Show/Hide
C16H18N4O
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0812651
 Compound Info 
1-Cyclobutyl-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-methanesulfonamide
   Show/Hide
C18H26N4O3S
  1
1
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0124474
 Compound Info 
4-(cyclobutylmethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C12H15N3O
  1
1
IC50 = 3400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0330677
 Compound Info 
4-cyclohexyl-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C13H17N3O
  1
1
IC50 = 3700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0207730
 Compound Info 
4-cyclopentyl-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C12H15N3O
  1
1
IC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0162855
 Compound Info 
4-cyclohexyl-5-(hydroxymethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C14H19N3O2
  1
1
IC50 = 4800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0356130
 Compound Info 
4-cyclohexyl-5-(2-hydroxyethyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C15H21N3O2
  1
1
IC50 = 8500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701644
 Compound Info 
N-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]cyclopentanecarboxamide
   Show/Hide
C19H26N4O2
  1
1
IC50 = 9100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0735624
 Compound Info 
N-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]cyclopropanecarboxamide
   Show/Hide
C17H22N4O2
  1
1
IC50 > 14000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0812652
 Compound Info 
rac-1-[2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetyl]pyrrolidine-3-carbonitrile
   Show/Hide
C20H25N5O2
  1
1
IC50 = 14000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0330676
 Compound Info 
4-cyclohexyl-3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridine-5-carbonitrile
   Show/Hide
C14H16N4O
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0812656
 Compound Info 
4-(4-trans-Hydroxycyclohexyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C13H17N3O2
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0701642
 Compound Info 
1-[2-[trans-4-(3-Methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]-pyridin-4-yl)cyclohexyl]acetyl]azetidine-3-carbonitrile
   Show/Hide
C19H23N5O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0692985
 Compound Info 
4-(4-trans-Aminocyclohexyl)-3-methyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C13H18N4O
  1
1
IC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0712223
 Compound Info 
N-Cyclopropyl-trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexanecarboxamide
   Show/Hide
C17H22N4O2
  1
1
IC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0768025
 Compound Info 
(1R)-2,2-Difluoro-N-[trans-4-(3-methyl-6-oxo-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]-cyclopropanecarboxamide
   Show/Hide
C17H20F2N4O2
  1
1
IC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0207733
 Compound Info 
4-cyclohexyl-1,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C12H15N3O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0330675
 Compound Info 
3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C13H11N3O
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ascites)
Cell Line Name Organism Disease
PEO1
 Cell Line Info 
Homo sapiens (Human) BRCA2-associated hereditary breast and ovarian cancer syndrome
MAST
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
Ramos
 Cell Line Info 
Homo sapiens (Human) Burkitt lymphoma
CA46
 Cell Line Info 
Homo sapiens (Human) Burkitt lymphoma
NCI-H716
 Cell Line Info 
Homo sapiens (Human) Cecum adenocarcinoma
COLO 205
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
COLO 201
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
DiFi
 Cell Line Info 
Homo sapiens (Human) Colorectal carcinoma
U-2932
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
DB
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HEC-50B
 Cell Line Info 
Homo sapiens (Human) Endometrial adenocarcinoma
SNU-5
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
SNU-16
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
SNU-620
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
SNU-638
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
SNU-668
 Cell Line Info 
Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
OVCAR-3
 Cell Line Info 
Homo sapiens (Human) High grade ovarian serous adenocarcinoma
OVCAR-5
 Cell Line Info 
Homo sapiens (Human) High grade ovarian serous adenocarcinoma
COV318
 Cell Line Info 
Homo sapiens (Human) High grade ovarian serous adenocarcinoma
ZR-75-1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
SK-HEP-1
 Cell Line Info 
Homo sapiens (Human) Liver and intrahepatic bile duct epithelial neoplasm
OV-90
 Cell Line Info 
Homo sapiens (Human) Ovarian adenocarcinoma
LK2
 Cell Line Info 
Homo sapiens (Human) Ovarian carcinoma
RMG-I
 Cell Line Info 
Homo sapiens (Human) Ovarian clear cell adenocarcinoma
PA-1
 Cell Line Info 
Homo sapiens (Human) Ovarian mixed germ cell tumor
SK-OV-3
 Cell Line Info 
Homo sapiens (Human) Ovarian serous cystadenocarcinoma
SKOV3/TR
 Cell Line Info 
Homo sapiens (Human) Ovarian serous cystadenocarcinoma
AsPC-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
HEC
 Cell Line Info 
Homo sapiens (Human) Peritoneal malignant mesothelioma
Ehrlich-Lettre ascites strain E
 Cell Line Info 
Mus musculus (Mouse) Malignant neoplasms of the mouse mammary gland
RAW 264.7
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
L1210
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
L1210/R81
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG-KO-STING
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
RAW 264
 Cell Line Info 
Mus musculus (Mouse) Mouse leukemia
J774
 Cell Line Info 
Mus musculus (Mouse) Mouse reticulum cell sarcoma
J774A1
 Cell Line Info 
Mus musculus (Mouse) Mouse reticulum cell sarcoma
HTC
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma