Brief Information of the Compound and Protein
Compound Name
rac-4-(2-Bicyclo[2.2.2]octanyl)-3-methyl-2,7-dihydropyrazolo-[3,4-b]pyridin-6-one
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PubChem ID
CID: 156021437
Canonical SMILES
Cc1[nH]nc2[nH]c(=O)cc(C3CC4CCC3CC4)c12
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Compound Formula C15H19N3O
Compound Structure
Protein Name
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
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Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000743 CellSensor STAT6-bla RA-1 Homo sapiens (Human)  1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 54 nM