General Information of the Protein
| Protein ID |
PT02003
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| Protein Name |
Thymidylate synthase
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| Gene Name |
THYA
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| Sequence |
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV
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| Organism |
Lacticaseibacillus casei, Lactobacillus casei
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| Protein Classification |
Enzyme
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Transferase
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| Function |
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
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| Uniprot ID | |||||
| Subcellular Location |
Cytoplasm
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000266 , L1210
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0039203 |
US9422297, PDDF
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C24H23N5O6
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4 |
| 1 | IC50 = 13 nM | ||
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| 2 | IC50 = 21 nM | ||
| 3 | IC50 = 36 nM | ||
| 4 | IC50 = 55 nM | ||