General Information of the Protein
Protein ID
PT06167
Protein Name
Deoxycytidine kinase
Secondarily
Protein Name
Deoxyadenosine kinase
Deoxyguanosine kinase
Gene Name
DCK
Sequence
MATPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQASEDWEVVPEPVARWCNVQSTQEEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRATPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTSFDYLQEVPVLTLDVNEDFKDKHESLVEKVKEFLSTL
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Transferase
Function
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.
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Uniprot ID
P43346
Ensembl ID
ENSG00000156136
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000266 , L1210
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0114441
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C20H24FN5O2S2
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0524790
 Compound Info 
2-[[5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C19H22FN5O2S2
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0144043
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 35 nM
 Bioactivity Info 
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CP0515354
 Compound Info 
2-[[2-(4-fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5S2
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0396011
 Compound Info 
2-[[2-(3-fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5S2
  1
1
IC50 = 175 nM
 Bioactivity Info 
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CP0375253
 Compound Info 
2-[[2-(3-fluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H14FN5S2
  1
1
IC50 = 255 nM
 Bioactivity Info 
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CP0385614
 Compound Info 
2-[[5-ethyl-2-(4-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H16FN5S2
  1
1
IC50 = 265 nM
 Bioactivity Info 
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CP0392032
 Compound Info 
2-[[2-[3-(3-fluoropropoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 330 nM
 Bioactivity Info 
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CP0505043
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H17F2N5S2
  1
1
IC50 = 385 nM
 Bioactivity Info 
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CP0524139
 Compound Info 
2-[[2-(4-fluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H14FN5S2
  1
1
IC50 = 395 nM
 Bioactivity Info 
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CP0524137
 Compound Info 
2-[[5-ethyl-2-(3-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H16FN5S2
  1
1
IC50 = 510 nM
 Bioactivity Info 
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CP0392034
 Compound Info 
2-[[2-[4-ethoxy-3-(2-fluoroethoxy)phenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 513 nM
 Bioactivity Info 
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CP0447080
 Compound Info 
6-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 528 nM
 Bioactivity Info 
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CP0432324
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 538 nM
 Bioactivity Info 
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CP0426769
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H13F2N5S2
  1
1
IC50 = 595 nM
 Bioactivity Info 
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CP0375252
 Compound Info 
6-[[2-[3-(3-fluoropropoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C17H19FN6O2S2
  1
1
IC50 = 603 nM
 Bioactivity Info 
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CP0538953
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-ethyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H15F2N5S2
  1
1
IC50 = 620 nM
 Bioactivity Info 
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CP0544884
 Compound Info 
2-[[2-[4-(2-fluoroethoxy)-3-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 808 nM
 Bioactivity Info 
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CP0524140
 Compound Info 
2-[[2-(4-ethoxy-3-methoxyphenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H19N5O2S2
  1
1
IC50 = 1120 nM
 Bioactivity Info 
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CP0524138
 Compound Info 
6-[[2-[4-ethoxy-3-(2-fluoroethoxy)phenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C17H19FN6O2S2
  1
1
IC50 = 1226 nM
 Bioactivity Info 
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CP0397095
 Compound Info 
2-[[2-[5-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 1445 nM
 Bioactivity Info 
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CP0538954
 Compound Info 
6-[[2-[4-(2-fluoroethoxy)-3-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 1612 nM
 Bioactivity Info 
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CP0544886
 Compound Info 
2-[[2-(3-methoxyphenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H15N5OS2
  1
1
IC50 = 1670 nM
 Bioactivity Info 
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CP0540623
 Compound Info 
2-[[2-(5-bromo-2-methoxyphenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H14BrN5OS2
  1
1
IC50 = 1760 nM
 Bioactivity Info 
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CP0396012
 Compound Info 
2-[[2-(4-methoxyphenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H15N5OS2
  1
1
IC50 = 2020 nM
 Bioactivity Info 
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CP0540624
 Compound Info 
2-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H15N5S2
  1
1
IC50 = 2320 nM
 Bioactivity Info 
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CP0515355
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methylphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5OS2
  1
1
IC50 = 2381 nM
 Bioactivity Info 
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CP0420297
 Compound Info 
6-[[2-[5-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 2649 nM
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CP0524991
 Compound Info 
6-[[2-[3-(2-fluoroethoxy)-4-methylphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6OS2
  1
1
IC50 = 3201 nM
 Bioactivity Info 
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CP0526565
 Compound Info 
2-[[2-[4-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 5469 nM
 Bioactivity Info 
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CP0524141
 Compound Info 
2-(4-methoxyphenyl)-4-(pyrimidin-2-ylsulfanylmethyl)-1,3-thiazole
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C15H13N3OS2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0526566
 Compound Info 
2-phenyl-4-(pyrimidin-2-ylsulfanylmethyl)-1,3-thiazole
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C14H11N3S2
  1
1
IC50 > 100000 nM
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Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01831 Deoxycytidine kinase Homo sapiens, Human
 Protein Info