General Information of the Protein
Protein ID
PT01831
Protein Name
Deoxycytidine kinase
Secondarily
Protein Name
Deoxyadenosine kinase
Deoxyguanosine kinase
Gene Name
DCK
Sequence
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
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Uniprot ID
Primary ID:
P27707

Secondarily ID:
B2R8V6
Q5TZY7
Q6FI11
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Ensembl ID
ENSG00000156136
HGNC ID
HGNC:2704
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000108 , CCRF-CEM
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0315891
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)-4-methoxybenzonitrile
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C21H19F2N7O3
  1
1
EC50 = 2 nM
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CP0244606
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1
EC50 = 4 nM
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CP0046926
 Compound Info 
2-(6-(4-(4-aminopyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1
EC50 = 5 nM
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CP0325259
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)-5-methoxybenzonitrile
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C21H19F2N7O3
  1
1
EC50 = 5 nM
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CP0244604
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)-5-methoxybenzonitrile
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C21H20FN7O3
  1
1
EC50 = 12 nM
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CP0037854
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1
EC50 = 13 nM
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CP0315890
 Compound Info 
2-(1-(6-(2-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1
EC50 = 13 nM
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CP0075461
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1
EC50 = 14 nM
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CP0330888
 Compound Info 
5-fluoro-2-(1-(5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H20F2N6O3
  1
1
EC50 = 14 nM
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CP0294469
 Compound Info 
5-fluoro-2-(1-(6-(2-fluorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C19H18F2N6O2
  1
1
EC50 = 15 nM
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CP0244602
 Compound Info 
5-fluoro-2-(1-(6-(2-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1
EC50 = 17 nM
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CP0294468
 Compound Info 
5-fluoro-2-(1-(6-(o-tolyloxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O2
  1
1
EC50 = 19 nM
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CP0330874
 Compound Info 
4-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1
EC50 = 20 nM
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CP0301822
 Compound Info 
2-(1-(6-(biphenyl-2-yloxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C25H23FN6O2
  1
1
EC50 = 26 nM
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CP0325258
 Compound Info 
2-(1-(6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C20H20ClFN6O2
  1
1
EC50 = 27 nM
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CP0240349
 Compound Info 
2-(1-(6-(3-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1
EC50 = 35 nM
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CP0037850
 Compound Info 
5-fluoro-2-(1-(6-(3-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1
EC50 = 36 nM
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CP0294470
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-methylpyrimidin-4-yloxy)benzonitrile
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C21H20FN7O2
  1
1
EC50 = 54 nM
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CP0315889
 Compound Info 
2-(1-(6-(4-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1
EC50 = 57 nM
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CP0244603
 Compound Info 
5-fluoro-2-(1-(6-(p-tolyloxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O2
  1
1
EC50 = 60 nM
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CP0150367
 Compound Info 
2-(1-(6-(2-ethylphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C21H23FN6O2
  1
1
EC50 = 61 nM
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CP0366409
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1
EC50 = 61 nM
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CP0294471
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-bromopyrimidin-4-yloxy)benzonitrile
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C20H17BrFN7O2
  1
1
EC50 = 80 nM
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CP0244605
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-2-methylpyrimidin-4-yloxy)benzonitrile
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C21H20FN7O2
  1
1
EC50 = 140 nM
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CP0128704
 Compound Info 
2-(2-(1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yl)ethoxy)-5-fluoropyrimidin-4-amine
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C23H23FN6OS
  1
1
EC50 = 160 nM
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CP0301821
 Compound Info 
5-fluoro-2-(1-(6-phenoxypyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C19H19FN6O2
  1
1
EC50 = 340 nM
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CP0075569
 Compound Info 
2-(6-(4-(4-amino-2-oxopyrimidin-1(2H)-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H18FN7O3
  1
1
EC50 = 350 nM
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CP0301820
 Compound Info 
2-(1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C21H19FN6OS
  1
1
EC50 = 700 nM
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CP0323224
 Compound Info 
2-((1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yl)methoxy)-5-fluoropyrimidin-4-amine
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C22H21FN6OS
  1
1
EC50 = 790 nM
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CP0075460
 Compound Info 
5-fluoro-2-(1-(6-(4-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1
EC50 = 890 nM
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CP0244601
 Compound Info 
2-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C16H10FN5OS
  1
1
EC50 = 13000 nM
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CP0245640
 Compound Info 
2-[4-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-(2-hydroxyethoxy)phenoxy]ethanol
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C21H27N5O4S2
  2
1
IC50 = 0.9 nM
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2
IC50 = 2.59 nM
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CP0519823
 Compound Info 
2-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-fluorophenoxy]ethanol
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C19H22FN5O2S2
  1
1
IC50 = 1.07 nM
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CP0303776
 Compound Info 
2-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethanol
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C20H25N5O3S2
  1
1
IC50 = 1.15 nM
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CP0553865
 Compound Info 
2-[(1R)-1-[2-[3-ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamine
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C25H35N5O5S2
  1
1
IC50 = 1.25 nM
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CP0133374
 Compound Info 
1-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H29N5O3S2
  2
1
IC50 = 1.4 nM
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2
IC50 = 1.44 nM
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CP0524789
 Compound Info 
3-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]propan-1-ol
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C21H27N5O3S2
  1
1
IC50 = 1.55 nM
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CP0395734
 Compound Info 
2-[3-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethanol
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C19H23N5O2S2
  1
1
IC50 = 2.45 nM
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CP0505042
 Compound Info 
2-[3-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-5-fluorophenoxy]ethanol
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C19H22FN5O2S2
  1
1
IC50 = 2.83 nM
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CP0505041
 Compound Info 
1-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]propan-2-ol
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C21H27N5O3S2
  1
1
IC50 = 2.85 nM
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CP0420296
 Compound Info 
2-[5-[4-[(4-aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethanol
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C20H24N4O3S2
  1
1
IC50 = 2.9 nM
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CP0114441
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C20H24FN5O2S2
  1
1
IC50 = 3 nM
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CP0371179
 Compound Info 
N-[2-[5-[4-[(1R)-1-(4,6-diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C20H26N6O4S3
  1
1
IC50 = 3.7 nM
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CP0053694
 Compound Info 
N-[2-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C21H28N6O4S3
  2
1
IC50 = 4.89 nM
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2
IC50 = 4.9 nM
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CP0524790
 Compound Info 
2-[[5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C19H22FN5O2S2
  1
1
IC50 = 7 nM
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CP0089923
 Compound Info 
2-[1-[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamine
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C19H22FN5O2S2
  1
1
IC50 = 7 nM
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CP0456800
 Compound Info 
N-[2-[3-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-5-fluorophenoxy]ethyl]methanesulfonamide
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C20H25FN6O3S3
  1
1
IC50 = 8.01 nM
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CP0116075
 Compound Info 
2-[1-[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamine
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C21H26FN5O2S2
  1
1
IC50 = 10 nM
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CP0524137
 Compound Info 
2-[[5-ethyl-2-(3-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H16FN5S2
  1
1
IC50 = 11 nM
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CP0354244
 Compound Info 
N-[2-[3-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethyl]methanesulfonamide
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C20H26N6O3S3
  2
1
IC50 = 11.58 nM
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2
IC50 = 11.6 nM
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CP0144043
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 18 nM
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CP0053692
 Compound Info 
5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenol
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C18H21N5O2S2
  2
1
IC50 = 18.6 nM
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2
IC50 = 18.62 nM
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CP0056384
 Compound Info 
1-[5-[4-[(4-aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H28N4O3S2
  1
1
IC50 = 21.8 nM
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CP0396011
 Compound Info 
2-[[2-(3-fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5S2
  1
1
IC50 = 31 nM
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CP0515354
 Compound Info 
2-[[2-(4-fluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5S2
  1
1
IC50 = 37 nM
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CP0385614
 Compound Info 
2-[[5-ethyl-2-(4-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H16FN5S2
  1
1
IC50 = 83 nM
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CP0375253
 Compound Info 
2-[[2-(3-fluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H14FN5S2
  1
1
IC50 = 92 nM
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CP0489191
 Compound Info 
N-[2-[5-[4-[(1S)-1-(4,6-diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C20H26N6O4S3
  1
1
IC50 = 94 nM
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CP0426769
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H13F2N5S2
  1
1
IC50 = 150 nM
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CP0538953
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-ethyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C16H15F2N5S2
  1
1
IC50 = 162 nM
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CP0505043
 Compound Info 
2-[[2-(3,5-difluorophenyl)-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H17F2N5S2
  1
1
IC50 = 173 nM
 Bioactivity Info 
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CP0392032
 Compound Info 
2-[[2-[3-(3-fluoropropoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 197 nM
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CP0432324
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 230 nM
 Bioactivity Info 
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CP0524139
 Compound Info 
2-[[2-(4-fluorophenyl)-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C15H14FN5S2
  1
1
IC50 = 230 nM
 Bioactivity Info 
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CP0392034
 Compound Info 
2-[[2-[4-ethoxy-3-(2-fluoroethoxy)phenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1
IC50 = 251 nM
 Bioactivity Info 
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CP0375252
 Compound Info 
6-[[2-[3-(3-fluoropropoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C17H19FN6O2S2
  1
1
IC50 = 297 nM
 Bioactivity Info 
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CP0303777
 Compound Info 
1-[5-[4-[(2,6-diaminopyrimidin-4-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H29N5O3S2
  1
1
IC50 = 395 nM
 Bioactivity Info 
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CP0544884
 Compound Info 
2-[[2-[4-(2-fluoroethoxy)-3-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 421 nM
 Bioactivity Info 
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CP0086838
 Compound Info 
2-[(1S)-1-[2-[3-ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamine
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C25H35N5O5S2
  1
1
IC50 = 429.5 nM
 Bioactivity Info 
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CP0447080
 Compound Info 
6-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 506 nM
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CP0524138
 Compound Info 
6-[[2-[4-ethoxy-3-(2-fluoroethoxy)phenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C17H19FN6O2S2
  1
1
IC50 = 512 nM
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CP0538954
 Compound Info 
6-[[2-[4-(2-fluoroethoxy)-3-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 534 nM
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CP0420297
 Compound Info 
6-[[2-[5-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6O2S2
  1
1
IC50 = 849 nM
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CP0397095
 Compound Info 
2-[[2-[5-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 1041 nM
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CP0524991
 Compound Info 
6-[[2-[3-(2-fluoroethoxy)-4-methylphenyl]-1,3-thiazol-4-yl]methylsulfanyl]-1,3,5-triazine-2,4-diamine
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C16H17FN6OS2
  1
1
IC50 = 1922 nM
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CP0515355
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methylphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5OS2
  1
1
IC50 = 1960 nM
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CP0526565
 Compound Info 
2-[[2-[4-(2-fluoroethoxy)-2-methoxyphenyl]-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C17H18FN5O2S2
  1
1
IC50 = 2367 nM
 Bioactivity Info 
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CP0301819
 Compound Info 
2-(4-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperazin-1-yl)-1-(pyrrolidin-1-yl)ethanone
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C22H25N5OS
  1
1
IC50 > 4000 nM
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CP0315888
 Compound Info 
2'-deoxy-5-fluorocytidine
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C9H12FN3O4
  1
1
IC50 > 4000 nM
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Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0046926
 Compound Info 
2-(6-(4-(4-aminopyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1 IC50 = 0.7 nM
CP0244606
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1 IC50 = 1 nM
CP0315891
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)-4-methoxybenzonitrile
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C21H19F2N7O3
  1
1 IC50 = 1 nM
CP0325259
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)-5-methoxybenzonitrile
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C21H19F2N7O3
  1
1 IC50 = 2 nM
CP0075461
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1 IC50 = 3 nM
CP0128704
 Compound Info 
2-(2-(1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yl)ethoxy)-5-fluoropyrimidin-4-amine
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C23H23FN6OS
  1
1 IC50 = 3 nM
CP0244604
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)-5-methoxybenzonitrile
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C21H20FN7O3
  1
1 IC50 = 3 nM
CP0301822
 Compound Info 
2-(1-(6-(biphenyl-2-yloxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C25H23FN6O2
  1
1 IC50 = 3 nM
CP0315890
 Compound Info 
2-(1-(6-(2-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1 IC50 = 3 nM
CP0037854
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1 IC50 = 4 nM
CP0330888
 Compound Info 
5-fluoro-2-(1-(5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H20F2N6O3
  1
1 IC50 = 4 nM
CP0244602
 Compound Info 
5-fluoro-2-(1-(6-(2-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1 IC50 = 5 nM
CP0294471
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-bromopyrimidin-4-yloxy)benzonitrile
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C20H17BrFN7O2
  1
1 IC50 = 5 nM
CP0330874
 Compound Info 
4-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H17F2N7O2
  1
1 IC50 = 5 nM
CP0294469
 Compound Info 
5-fluoro-2-(1-(6-(2-fluorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C19H18F2N6O2
  1
1 IC50 = 6 nM
CP0294468
 Compound Info 
5-fluoro-2-(1-(6-(o-tolyloxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O2
  1
1 IC50 = 9 nM
CP0325258
 Compound Info 
2-(1-(6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C20H20ClFN6O2
  1
1 IC50 = 9 nM
CP0150367
 Compound Info 
2-(1-(6-(2-ethylphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C21H23FN6O2
  1
1 IC50 = 10 nM
CP0244605
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-2-methylpyrimidin-4-yloxy)benzonitrile
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C21H20FN7O2
  1
1 IC50 = 10 nM
CP0056384
 Compound Info 
1-[5-[4-[(4-aminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H28N4O3S2
  2
1 IC50 = 11.2 nM
2 Ki = 1.8 nM
CP0366409
 Compound Info 
3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrile
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C20H18FN7O2
  1
1 IC50 = 13 nM
CP0053694
 Compound Info 
N-[2-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C21H28N6O4S3
  2
1 IC50 = 14.1 nM
2 Ki = 0.5 nM
CP0133374
 Compound Info 
1-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H29N5O3S2
  2
1 IC50 = 14.5 nM
2 Ki = 0.8 nM
CP0303776
 Compound Info 
2-[5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethanol
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C20H25N5O3S2
  2
1 IC50 = 14.6 nM
2 Ki = 0.5 nM
CP0354244
 Compound Info 
N-[2-[3-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]phenoxy]ethyl]methanesulfonamide
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C20H26N6O3S3
  2
1 IC50 = 16.8 nM
2 Ki = 1.9 nM
CP0245640
 Compound Info 
2-[4-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-(2-hydroxyethoxy)phenoxy]ethanol
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C21H27N5O4S2
  2
1 IC50 = 17.9 nM
2 Ki = 2 nM
CP0315889
 Compound Info 
2-(1-(6-(4-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1 IC50 = 19 nM
CP0244603
 Compound Info 
5-fluoro-2-(1-(6-(p-tolyloxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O2
  1
1 IC50 = 21 nM
CP0294470
 Compound Info 
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-methylpyrimidin-4-yloxy)benzonitrile
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C21H20FN7O2
  1
1 IC50 = 21 nM
CP0240349
 Compound Info 
2-(1-(6-(3-chlorophenoxy)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C19H18ClFN6O2
  1
1 IC50 = 22 nM
CP0037850
 Compound Info 
5-fluoro-2-(1-(6-(3-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1 IC50 = 23 nM
CP0089923
 Compound Info 
2-[1-[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamine
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C19H22FN5O2S2
  2
1 IC50 = 24.7 nM
2 Ki = 6.8 nM
CP0053692
 Compound Info 
5-[4-[(4,6-diaminopyrimidin-2-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenol
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C18H21N5O2S2
  2
1 IC50 = 26.1 nM
2 Ki = 8.9 nM
CP0371179
 Compound Info 
N-[2-[5-[4-[(1R)-1-(4,6-diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C20H26N6O4S3
  2
1 IC50 = 27.8 nM
2 Ki = 9.2 nM
CP0553865
 Compound Info 
2-[(1R)-1-[2-[3-ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamine
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C25H35N5O5S2
  2
1 IC50 = 31.7 nM
2 Ki = 14 nM
CP0075460
 Compound Info 
5-fluoro-2-(1-(6-(4-methoxyphenoxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C20H21FN6O3
  1
1 IC50 = 33 nM
CP0323224
 Compound Info 
2-((1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yl)methoxy)-5-fluoropyrimidin-4-amine
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C22H21FN6OS
  1
1 IC50 = 34 nM
CP0116075
 Compound Info 
2-[1-[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]ethylsulfanyl]pyrimidine-4,6-diamine
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C21H26FN5O2S2
  2
1 IC50 = 37.2 nM
2 Ki = 16.6 nM
CP0301820
 Compound Info 
2-(1-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C21H19FN6OS
  1
1 IC50 = 38 nM
CP0075569
 Compound Info 
2-(6-(4-(4-amino-2-oxopyrimidin-1(2H)-yloxy)piperidin-1-yl)-5-fluoropyrimidin-4-yloxy)benzonitrile
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C20H18FN7O3
  1
1 IC50 = 63 nM
CP0301821
 Compound Info 
5-fluoro-2-(1-(6-phenoxypyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine
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C19H19FN6O2
  1
1 IC50 = 95 nM
CP0489191
 Compound Info 
N-[2-[5-[4-[(1S)-1-(4,6-diaminopyrimidin-2-yl)sulfanylethyl]-5-methyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]ethyl]methanesulfonamide
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C20H26N6O4S3
  2
1 IC50 = 605 nM
2 Ki = 585 nM
CP0244601
 Compound Info 
2-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yloxy)-5-fluoropyrimidin-4-amine
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C16H10FN5OS
  1
1 IC50 = 720 nM
CP0303777
 Compound Info 
1-[5-[4-[(2,6-diaminopyrimidin-4-yl)sulfanylmethyl]-5-propyl-1,3-thiazol-2-yl]-2-methoxyphenoxy]-2-methylpropan-2-ol
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C22H29N5O3S2
  2
1 IC50 = 754 nM
2 Ki = 735 nM
CP0086838
 Compound Info 
2-[(1S)-1-[2-[3-ethoxy-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamine
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C25H35N5O5S2
  2
1 IC50 = 5632 nM
2 Ki = 5607 nM
CP0114441
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C20H24FN5O2S2
  1
1 Ki = 1.5 nM
CP0144043
 Compound Info 
2-[[2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methylsulfanyl]pyrimidine-4,6-diamine
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C18H20FN5O2S2
  1
1 Ki = 9.5 nM
CP0036494
 Compound Info 
DEOXYCYTIDINE
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C9H13N3O4
  2
1 Km = 1100 nM
2 Km = 2800 nM
Clinical Information about the Protein
Target 1 ( Deoxycytidine kinase (DCK) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06167 Deoxycytidine kinase Mus musculus, Mouse
 Protein Info