General Information of the Compound
Compound ID
CP0504859
Compound Name
6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline-3-carbonitrile Hydrochloride
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Structure
Formula
C19H17N3O2S
Molecular Weight
351.431
Canonical SMILES
COc1cc2ncc(C#N)c(Nc3cccc(SC)c3)c2cc1OC
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InChI
InChI=1S/C19H17N3O2S/c1-23-17-8-15-16(9-18(17)24-2)21-11-12(10-20)19(15)22-13-5-4-6-14(7-13)25-3/h4-9,11H,1-3H3,(H,21,22)
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InChIKey
ZSJDOQUXSFYFRM-UHFFFAOYSA-N
Physicochemical Property
logP
4.58918
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
67.17
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5328860
ChEMBL ID
CHEMBL114496
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 758.58 nM
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