General Information of the Compound
Compound ID
CP0328916
Compound Name
Benzyl-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine
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Structure
Formula
C18H15FN4O
Molecular Weight
322.343
Canonical SMILES
Fc1ccc2Oc3ncnc(NCc4ccccc4)c3NCc2c1
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InChI
InChI=1S/C18H15FN4O/c19-14-6-7-15-13(8-14)10-20-16-17(22-11-23-18(16)24-15)21-9-12-4-2-1-3-5-12/h1-8,11,20H,9-10H2,(H,21,22,23)
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InChIKey
PBYYAOQNRJEOJN-UHFFFAOYSA-N
Physicochemical Property
logP
3.9456
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
59.07
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11232492
SID: 16316333
ChEMBL ID
CHEMBL379041
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8900 nM