General Information of the Compound
Compound ID
CP0215296
Compound Name
N-[4-(3-bromoanilino)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-8-yl]methanesulfonamide
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Structure
Formula
C18H16BrN5O3S
Molecular Weight
462.329
Canonical SMILES
CS(=O)(=O)Nc1ccc2Oc3ncnc(Nc4cccc(Br)c4)c3NCc2c1
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InChI
InChI=1S/C18H16BrN5O3S/c1-28(25,26)24-14-5-6-15-11(7-14)9-20-16-17(21-10-22-18(16)27-15)23-13-4-2-3-12(19)8-13/h2-8,10,20,24H,9H2,1H3,(H,21,22,23)
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InChIKey
JCKYGUUVRSHCJN-UHFFFAOYSA-N
Physicochemical Property
logP
4.072
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
105.24
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44409056
ChEMBL ID
CHEMBL382186
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 7000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4100 nM