General Information of the Compound
Compound ID
CP0078046
Compound Name
N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]prop-2-enamide
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Structure
Formula
C19H13BrN4O
Molecular Weight
393.244
Canonical SMILES
Brc1cccc(Nc2c(cnc3ccc(NC(=O)C=C)cc23)C#N)c1
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InChI
InChI=1S/C19H13BrN4O/c1-2-18(25)23-15-6-7-17-16(9-15)19(12(10-21)11-22-17)24-14-5-3-4-13(20)8-14/h2-9,11H,1H2,(H,22,24)(H,23,25)
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InChIKey
MSLIBSZZLAWHQM-UHFFFAOYSA-N
Physicochemical Property
logP
4.73708
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
77.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9930439
SID: 14903163
ChEMBL ID
CHEMBL281300
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 588.84 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9.7 nM
2 IC50 = 86.9 nM
3 IC50 = 590 nM