General Information of the Compound
Compound ID
CP0528800
Compound Name
N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]-4-(dicyclopropylamino)but-2-ynamide
    Show/Hide
Structure
Formula
C26H22BrN5O
Molecular Weight
500.4
Canonical SMILES
Brc1cccc(Nc2c(cnc3ccc(NC(=O)C#CCN(C4CC4)C4CC4)cc23)C#N)c1
    Show/Hide
InChI
InChI=1S/C26H22BrN5O/c27-18-3-1-4-19(13-18)31-26-17(15-28)16-29-24-11-6-20(14-23(24)26)30-25(33)5-2-12-32(21-7-8-21)22-9-10-22/h1,3-4,6,11,13-14,16,21-22H,7-10,12H2,(H,29,31)(H,30,33)
    Show/Hide
InChIKey
QNVUBJWWBBKDIS-UHFFFAOYSA-N
Physicochemical Property
logP
5.18128
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
81.05
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 56659589
ChEMBL ID
CHEMBL1797541
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS