General Information of the Compound
Compound ID
CP0504858
Compound Name
4-(3-Bromophenylamino)-6,7-diethoxyquinoline-3-carbonitrile
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Structure
Formula
C20H18BrN3O2
Molecular Weight
412.287
Canonical SMILES
CCOc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OCC
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InChI
InChI=1S/C20H18BrN3O2/c1-3-25-18-9-16-17(10-19(18)26-4-2)23-12-13(11-22)20(16)24-15-7-5-6-14(21)8-15/h5-10,12H,3-4H2,1-2H3,(H,23,24)
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InChIKey
ZXILYRWRAKLTOG-UHFFFAOYSA-N
Physicochemical Property
logP
5.40998
Rotatable Bonds
6
Heavy Atom Count
26
Polar Areas
67.17
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5328838
SID: 14855415
ChEMBL ID
CHEMBL109212
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 416.87 nM
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