General Information of the Compound
| Compound ID |
CP0011998
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| Compound Name |
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine
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| Synonyms |
183322-45-4
4-Quinazolinamine, N-(3-bromo
4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride
AG 1517
AG 1517 hydrochloride
AHJ252P69N
C16H15BrClN3O2
CHEMBL1204168
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
PD 153035 HYDROCHLORIDE
PD-153035
PD-153035 hydrochloride
PD153035 (Hydrochloride)
PD153035 HCl
PD153035 hydrochloride
PD153035.HCl
SU 5271
SU-5271 hydrochloride
Tyrphostin AG 1517
UNII-AHJ252P69N
ZM 252868
pd 153035
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| Structure |
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| Formula |
C16H14BrN3O2
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| Molecular Weight |
360.211
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| Canonical SMILES |
COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
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| InChI |
InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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| InChIKey |
LSPANGZZENHZNJ-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein ID: PT01920, Cyclin-G-associated kinase
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000052 | A-431 | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 12600 nM
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Clinical Information about the Compound