General Information of the Compound
Compound ID
CP0243355
Compound Name
6-cyclopentyloxy-7-methoxy-N-(4-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
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Structure
Formula
C29H30N2O4
Molecular Weight
470.569
Canonical SMILES
COc1ccc(NC(=O)C2Cc3cc(OC4CCCC4)c(OC)cc3C(=N2)c2ccccc2)cc1
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InChI
InChI=1S/C29H30N2O4/c1-33-22-14-12-21(13-15-22)30-29(32)25-16-20-17-27(35-23-10-6-7-11-23)26(34-2)18-24(20)28(31-25)19-8-4-3-5-9-19/h3-5,8-9,12-15,17-18,23,25H,6-7,10-11,16H2,1-2H3,(H,30,32)
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InChIKey
LPCQQYYZRHNSQG-UHFFFAOYSA-N
Physicochemical Property
logP
5.426
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
69.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155535906
ChEMBL ID
CHEMBL4472790
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01305, 3',5'-cyclic-AMP phosphodiesterase 4B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 6230 nM
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Biochemical Assays
1 IC50 = 29360 nM
Protein ID: PT01538, 3',5'-cyclic-AMP phosphodiesterase 4D
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 32780 nM
   TI
   LI
   LO
   TS