General Information of the Cell Line
Cell Line ID
CL000699
Cell Line Name
HCC4006
Synonyms
HCC-4006
Hamon Cancer Center 4006
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1269
Tissue Information
Pleural effusion
Disease
Lung adenocarcinoma (NCIt: C3512)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01405, RIP-like-interacting CLARP kinase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0944208
 Compound Info 
5-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)-amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-N-((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)pyrazine-2-carboxamide
   Show/Hide
C53H70N14O7S
  1
1
IC50 = 0.1 nM
 Bioactivity Info 
   TI
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CP0966877
 Compound Info 
(S)-N-((S)-1-(1-(5-(4-(2-((6-(tert-Butylsulfonyl)-4-(((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)ethyl)piperazin-1-yl)-pyrazine-2-carbonyl)piperidin-4-yl)-2-(S)-2-(4-(4-fluorobenzoyl)-thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C53H67FN14O7S2
  1
1
IC50 = 0.1585 nM
 Bioactivity Info 
   TI
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CP0559658
 Compound Info 
(2S,4S)-4-[[2-[2-[2-[2-[2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinolin-7-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-1-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-[(1R)-1-phenylpropyl]pyrrolidine-2-carboxamide
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C54H74N8O11S2
  1
1
IC50 = 1.995 nM
 Bioactivity Info 
   TI
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CP0550778
 Compound Info 
(2S)-N-[(1S)-1-[1-[2-[2-[2-[2-[2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinolin-7-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]acetyl]piperidin-4-yl]-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide
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C55H67FN8O11S3
  1
1
IC50 = 5.012 nM
 Bioactivity Info 
   TI
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CP0968793
 Compound Info 
(5S,8S,10aR)-3-(5-(4-(3-((6-(tert-butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)pyrazine-2-carbonyl)-5-((S)-2-(methylamino)propanamido)-6-oxo-N-(1,2,3,4-tetrahydronaphthalen-1-yl)decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
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C53H70N14O7S
  1
1
IC50 = 6.31 nM
 Bioactivity Info 
   TI
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CP0944190
 Compound Info 
(S)-N-((S)-1-(1-(2-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-pyrimidine-5-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)-thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C54H67FN14O7S2
  1
1
IC50 = 7.943 nM
 Bioactivity Info 
   TI
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CP0962680
 Compound Info 
2-((2R,5R)-2-(((R)-4-(5-(4-(3-((6-(tert-Butylsulfonyl)-4-((3,4-dimethyl-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)-piperazine-1-carbonyl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-methyl)-5-methylpiperazin-1-yl)-1-(6-(4-fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone
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C59H78FN15O6S
  1
1
IC50 = 7.943 nM
 Bioactivity Info 
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CP0533814
 Compound Info 
(3R)-7-[2-[2-[2-[2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinolin-7-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]-2-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
   Show/Hide
C58H73N7O10S2
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0868240
 Compound Info 
(S)-N-((S)-1-(1-(6-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-nicotinoyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)-pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C55H68FN13O7S2
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0953690
 Compound Info 
(5S,8S,10aR)-3-(5-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-pyrazine-2-carbonyl)-5-((S)-2-(methylamino)propanamido)-6-oxo-N-((R)-1,2,3,4-Tetrahydronaphthalen-1-yl)decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
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C50H66F2N14O7S
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0963888
 Compound Info 
(S)-N-((S)-1-(1-(2-(4-(((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)methyl)piperidin-1-yl)-pyrimidine-5-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)-thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C53H64FN13O7S2
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0965435
 Compound Info 
(S)-N-((S)-1-(1-(5-(4-(3-(6-(tert-butylsulfonyl)-4-(4,5-dimethyl-1H-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)piperazin-1-yl)pyrazine-2-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C54H67FN14O7S2
  1
1
IC50 = 12.59 nM
 Bioactivity Info 
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CP0966674
 Compound Info 
5-(4-(3-((6-(tert-butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-N-((3S)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-5-((1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)pyrazine-2-carboxamide
   Show/Hide
C54H74N14O7S
  1
1
IC50 = 12.59 nM
 Bioactivity Info 
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CP0963889
 Compound Info 
5-(4-(3-(6-(tert-butylsulfonyl)-4-(4,5-dimethyl-1H-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)piperazin-1-yl)-N-((3S,5S)-5-(2,6-difluorophenylcarbamoyl)-1-((S)-3,3-dimethyl-2-((R)-2-(methylamino)propanamido)butanoyl)pyrrolidin-3-yl)pyrazine-2-carboxamide
   Show/Hide
C58H76FN15O5S
  1
1
IC50 = 25.12 nM
 Bioactivity Info 
   TI
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CP0965481
 Compound Info 
(S)-N-((S)-1-(1-(4-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperazin-1-yl)-benzoyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)-pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C56H69FN12O7S2
  1
1
IC50 = 31.62 nM
 Bioactivity Info 
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CP0966876
 Compound Info 
(S)-N-((S)-1-(1-(2-(4-(3-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)piperidin-1-yl)-pyrimidine-5-carbonyl)Piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C55H68FN13O7S2
  1
1
IC50 = 31.62 nM
 Bioactivity Info 
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CP0969474
 Compound Info 
(S)-N-((S)-1-(1-(2-(4-(2-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)ethyl)piperidin-1-yl)-pyrimidine-5-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)-thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C54H66FN13O7S2
  1
1
IC50 = 39.81 nM
 Bioactivity Info 
   TI
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CP0960425
 Compound Info 
(S)-N-((S)-1-(1-(6-(4-(2-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)ethyl)piperazin-1-yl)-nicotinoyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)-pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C54H66FN13O7S2
  1
1
IC50 = 125.89 nM
 Bioactivity Info 
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CP0953689
 Compound Info 
(S)-N-((S)-1-(1-(14-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-l)oxy)-3,6,9,12-tetraoxatetradecanoyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)-thiazol-2-l)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C52H69FN10O11S2
  1
1
IC50 = 158.49 nM
 Bioactivity Info 
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CP0962679
 Compound Info 
(S)-N-((S)-1-(1-(5-(4-(2-(6-(tert-butylsulfonyl)-4-(4,5-dimethyl-1H-pyrazol-3-ylamino)quinazolin-7-yloxy)ethyl)piperazin-1-yl)pyrazine-2-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
   Show/Hide
C53H65FN14O7S2
  1
1
IC50 = 158.49 nM
 Bioactivity Info 
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CP0969151
 Compound Info 
(S)-N-((S)-1-(1-(2-(4-(2-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)ethyl)piperazin-1-yl)-pyrimidine-5-carbonyl)piperidin-4-yl)-2-((S)-2-(4-(4-fluorobenzoyl)-thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)-propanamide
   Show/Hide
C53H65FN14O7S2
  1
1
IC50 = 251.19 nM
 Bioactivity Info 
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CP0953688
 Compound Info 
(S)-7-(2-(2-(2-(2-((6-(tert-Butylsulfonyl)-4-((4,5-dimethyl-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)-ethoxy)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)-butanoyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C55H75N9O10S
  1
1
IC50 = 398.11 nM
 Bioactivity Info 
   TI
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pleural effusion)
Cell Line Name Organism Disease
U-937
 Cell Line Info 
Homo sapiens (Human) Adult acute monocytic leukemia
SU-DHL-1
 Cell Line Info 
Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
SR
 Cell Line Info 
Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
MC116
 Cell Line Info 
Homo sapiens (Human) B-cell non-Hodgkin lymphoma
K-562
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/A02
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/Adr
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/R7
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/DOX
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
MDA-MB-231
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-415
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-468
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
SK-BR-3
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
AU565
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
CAL-51
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
CAL-120
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
DG-75
 Cell Line Info 
Homo sapiens (Human) Burkitt lymphoma
SUP-T1
 Cell Line Info 
Homo sapiens (Human) Childhood T lymphoblastic lymphoma
Pfeiffer
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
WSU-DLCL2
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
Karpas-422
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
DoHH2
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
KATO III
 Cell Line Info 
Homo sapiens (Human) Down syndrome
GIST-T1
 Cell Line Info 
Homo sapiens (Human) Gastrointestinal stromal tumor
GIST-5R
 Cell Line Info 
Homo sapiens (Human) Gastrointestinal stromal tumor
MZ-CRC-1
 Cell Line Info 
Homo sapiens (Human) Hereditary thyroid gland medullary carcinoma
L-428
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
KM-H2
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
T-47D
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/2a
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T-47
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 MX100
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/VP
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-2a
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D:A18
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MVLN
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF/MX
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/Topo
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD2
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7aro
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M6
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-10
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M24
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7piGST
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-Y1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/ADM
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7:WS8
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-FLV1000
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-neo/Her2
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 cl.24
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/DX1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-LC3
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D-KBluc
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
Calu-6
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
Calu-3
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC78
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H3122
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H3255
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2122
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
COR-L105
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1437
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1792
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
DFCI032
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1355
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H460
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
U-1810
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
COR-L23/R
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H460/MX20
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H460R
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H69AR
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H69
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
GLC-4/ADR
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
STC 1
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
RERF-LC-A1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Calu-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
HCC95
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
RERF-LC-AI Tet-off
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1650
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H1666
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H929
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
KMS-11
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
UTMC-2
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
KMS-12-PE
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
NCI-H226
 Cell Line Info 
Homo sapiens (Human) Pleural epithelioid mesothelioma
Karpas-1106P
 Cell Line Info 
Homo sapiens (Human) Primary mediastinal (thymic) large B-cell lymphoma