General Information of the Protein
Protein ID
PT02790
Protein Name
Dipeptidyl peptidase 1
Secondarily
Protein Name
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Dipeptidyl transferase
Dipeptidyl peptidase I exclusion domain chain
Dipeptidyl peptidase I heavy chain
Dipeptidyl peptidase I light chain
Gene Name
CTSC
Secondarily
Gene Name
CPPI
Sequence
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Cysteine protease
>
Cysteine protease CA clan
>
Cysteine protease C1A family
Function
Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921).
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Uniprot ID
Primary ID:
P53634

Secondarily ID:
A8K7V2
B5MDD5
Q2HIY8
Q53G93
Q71E75
Q71E76
Q7M4N9
Q7Z3G7
Q7Z5U7
Q8WY99
Q8WYA7
Q8WYA8
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Ensembl ID
ENSG00000109861
HGNC ID
HGNC:2528
Subcellular Location
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000040 , THP-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0116659
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyano-3-methylsulfanylphenyl)phenyl]ethyl]piperidine-2-carboxamide
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C23H24N4OS
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0426159
 Compound Info 
N-[5-[6-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyanilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C34H44N6O3
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0477430
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-(trifluoromethyl)phenyl]prop-2-enamide
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C32H37F3N6O3
  1
1
IC50 = 1.8 nM
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CP0157175
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C32H40N6O3
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
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CP0426158
 Compound Info 
N-[2-methyl-5-[6-[4-(4-methylpiperazin-1-yl)anilino]-3-piperidin-1-ylpyridin-2-yl]oxyphenyl]prop-2-enamide
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C31H38N6O2
  1
1
IC50 = 2.7 nM
 Bioactivity Info 
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CP0529931
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-(4-methylpiperazin-1-yl)pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C32H41N7O3
  1
1
IC50 = 2.8 nM
 Bioactivity Info 
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CP0086670
 Compound Info 
1-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide
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C23H24N4O
  1
1
IC50 = 3.162 nM
 Bioactivity Info 
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CP0240119
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-morpholin-4-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C31H38N6O4
  1
1
IC50 = 3.9 nM
 Bioactivity Info 
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CP0348152
 Compound Info 
N-[5-[3-(3-hydroxypiperidin-1-yl)-6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C32H40N6O4
  1
1
IC50 = 4.9 nM
 Bioactivity Info 
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CP0157176
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]oxane-4-carboxamide
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C22H22N4O2
  1
1
IC50 = 5.012 nM
 Bioactivity Info 
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CP0477429
 Compound Info 
N-[5-[6-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]-3-piperidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C31H39N7O3
  1
1
IC50 = 6.5 nM
 Bioactivity Info 
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CP0537925
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxy-2-(trifluoromethyl)phenyl]prop-2-enamide
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C31H35F3N6O3
  1
1
IC50 = 6.7 nM
 Bioactivity Info 
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CP0168574
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]piperidine-2-carboxamide
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C24H26N4O2
  1
1
IC50 = 7.943 nM
 Bioactivity Info 
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CP0241083
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(3-methylsulfonylphenyl)phenyl]ethyl]oxane-4-carboxamide
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C22H25N3O4S
  1
1
IC50 = 7.943 nM
 Bioactivity Info 
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CP0086664
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-2-carboxamide
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C22H22N4O
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0089882
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
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C23H24N4O4
  1
1
IC50 = 10.3 nM
 Bioactivity Info 
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CP0167818
 Compound Info 
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C31H38N6O3
  1
1
IC50 = 12.3 nM
 Bioactivity Info 
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CP0116666
 Compound Info 
(2S,4S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide
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C22H22N4O2
  1
1
IC50 = 12.59 nM
 Bioactivity Info 
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CP0473308
 Compound Info 
N-[2-methoxy-5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-pyrrolidin-1-ylpyridin-2-yl]oxyphenyl]prop-2-enamide
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C31H38N6O4
  1
1
IC50 = 21.3 nM
 Bioactivity Info 
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CP0245064
 Compound Info 
5-chloro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1
IC50 = 24.3 nM
 Bioactivity Info 
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CP0426160
 Compound Info 
N-[5-[3-(3-hydroxypyrrolidin-1-yl)-6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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C31H38N6O4
  1
1
IC50 = 28.4 nM
 Bioactivity Info 
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CP0086671
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]oxane-4-carboxamide
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C21H23N3O2
  1
1
IC50 = 31.62 nM
 Bioactivity Info 
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CP0423361
 Compound Info 
5-chloro-2-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H23ClF3N7
  1
1
IC50 = 32.5 nM
 Bioactivity Info 
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CP0061789
 Compound Info 
(2S,4S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide
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C24H26N4O3
  1
1
IC50 = 39.81 nM
 Bioactivity Info 
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CP0245065
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  2
1
IC50 = 42.3 nM
 Bioactivity Info 
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2
IC50 = 48.4 nM
 Bioactivity Info 
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CP0351089
 Compound Info 
5-chloro-2-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C23H25ClF3N7
  1
1
IC50 = 43.5 nM
 Bioactivity Info 
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CP0156622
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(2-methyl-3-oxo-1H-isoindol-5-yl)phenyl]ethyl]oxane-4-carboxamide
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C24H26N4O3
  1
1
IC50 = 50.12 nM
 Bioactivity Info 
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CP0138583
 Compound Info 
5-chloro-2-N-(5-piperazin-1-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H19ClF3N7
  1
1
IC50 = 54.6 nM
 Bioactivity Info 
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CP0058214
 Compound Info 
(S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide
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C19H21N3O
  1
1
IC50 = 63.1 nM
 Bioactivity Info 
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CP0578761
 Compound Info 
N-[4-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide
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C21H17ClN6OS
  1
1
IC50 = 63.9 nM
 Bioactivity Info 
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CP0351029
 Compound Info 
5-fluoro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21F4N7
  1
1
IC50 = 66.8 nM
 Bioactivity Info 
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CP0564775
 Compound Info 
5-chloro-2-N-[5-(4-propylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C23H25ClF3N7
  1
1
IC50 = 75.5 nM
 Bioactivity Info 
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CP0176739
 Compound Info 
5-chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine
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C22H21ClF3N5O
  1
1
IC50 = 76.9 nM
 Bioactivity Info 
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CP0351352
 Compound Info 
5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1
IC50 = 81.5 nM
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CP0546700
 Compound Info 
5-chloro-2-N-(6-thiophen-3-ylpyridazin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C19H12ClF3N6S
  1
1
IC50 = 89.5 nM
 Bioactivity Info 
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CP0480229
 Compound Info 
5-fluoro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13F4N5S
  1
1
IC50 = 89.8 nM
 Bioactivity Info 
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CP0576984
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-diamine
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C21H15ClF3N5S
  1
1
IC50 = 89.8 nM
 Bioactivity Info 
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CP0444643
 Compound Info 
5-methyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16F3N5S
  1
1
IC50 = 90.4 nM
 Bioactivity Info 
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CP0517068
 Compound Info 
2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H14F3N5S
  1
1
IC50 = 92.4 nM
 Bioactivity Info 
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CP0480230
 Compound Info 
5-methoxy-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16F3N5OS
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0546699
 Compound Info 
N-[4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide
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C28H21F3N6OS
  1
1
IC50 = 101.5 nM
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CP0578309
 Compound Info 
5-chloro-4-N-(4-fluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H13ClFN5S
  1
1
IC50 = 104.8 nM
 Bioactivity Info 
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CP0569746
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5OS
  1
1
IC50 = 109.5 nM
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CP0568246
 Compound Info 
4-N-(4-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H15ClN6S
  1
1
IC50 = 110.7 nM
 Bioactivity Info 
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CP0451163
 Compound Info 
5-chloro-2-N-[5-[4-(dimethylamino)phenyl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H20ClF3N6
  1
1
IC50 = 114 nM
 Bioactivity Info 
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CP0545107
 Compound Info 
N-[3-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide
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C21H17ClN6OS
  1
1
IC50 = 115.4 nM
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CP0561721
 Compound Info 
5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H20ClF3N8
  1
1
IC50 = 120 nM
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CP0576814
 Compound Info 
5-chloro-4-N-piperidin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C18H19ClN6S
  1
1
IC50 = 120.3 nM
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CP0545103
 Compound Info 
5-chloro-2-N-(5-thiophen-2-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1
IC50 = 129.4 nM
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CP0570172
 Compound Info 
5-chloro-4-N-pyridin-2-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C18H13ClN6S
  1
1
IC50 = 140.7 nM
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CP0176738
 Compound Info 
5-chloro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine
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C21H20ClF3N6O
  1
1
IC50 = 141 nM
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CP0561798
 Compound Info 
5-chloro-2-N-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H20ClF3N8
  1
1
IC50 = 144 nM
 Bioactivity Info 
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CP0176737
 Compound Info 
5-methoxy-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H24F3N7O
  1
1
IC50 = 153 nM
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CP0545104
 Compound Info 
4-N-(3-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H15ClN6S
  1
1
IC50 = 155.9 nM
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CP0247122
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]piperidine-2-carboxamide
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C21H23N3O
  1
1
IC50 = 158.49 nM
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CP0546852
 Compound Info 
5-chloro-4-N-(3,4-difluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H12ClF2N5S
  1
1
IC50 = 159.3 nM
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CP0550068
 Compound Info 
5-chloro-2-N-(6-thiophen-3-ylpyridin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1
IC50 = 159.6 nM
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CP0576853
 Compound Info 
5-chloro-4-N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C20H12ClF4N5S
  1
1
IC50 = 169.6 nM
 Bioactivity Info 
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CP0579313
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5OS
  1
1
IC50 = 179.8 nM
 Bioactivity Info 
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CP0579315
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1
IC50 = 183.6 nM
 Bioactivity Info 
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CP0423364
 Compound Info 
2-N-[5-(4-aminopiperidin-1-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1
IC50 = 186 nM
 Bioactivity Info 
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CP0578307
 Compound Info 
5-chloro-2-N-(3-nitro-5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H12ClF3N6O2S
  1
1
IC50 = 197.3 nM
 Bioactivity Info 
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CP0579319
 Compound Info 
5-bromo-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13BrF3N5S
  1
1
IC50 = 202.5 nM
 Bioactivity Info 
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CP0579868
 Compound Info 
5-chloro-2-N-(3-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H14ClF3N4S
  1
1
IC50 = 203.4 nM
 Bioactivity Info 
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CP0451145
 Compound Info 
5-chloro-2-N-pyridin-2-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1
IC50 = 207 nM
 Bioactivity Info 
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CP0517067
 Compound Info 
5-methyl-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H24F3N7
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0423362
 Compound Info 
2-N-[5-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H25ClF3N7
  1
1
IC50 = 247 nM
 Bioactivity Info 
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CP0546695
 Compound Info 
5-chloro-2-N-(4-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1
IC50 = 259.6 nM
 Bioactivity Info 
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CP0132348
 Compound Info 
2-N-[5-(4-aminophenyl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H16ClF3N6
  1
1
IC50 = 281 nM
 Bioactivity Info 
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CP0132347
 Compound Info 
5-chloro-2-N-(5-phenylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H15ClF3N5
  1
1
IC50 = 286 nM
 Bioactivity Info 
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CP0444642
 Compound Info 
5-chloro-2-N-[5-(1-methylpyrazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H15ClF3N7
  1
1
IC50 = 286 nM
 Bioactivity Info 
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CP0576816
 Compound Info 
5-(4-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H17ClF3N5S
  1
1
IC50 = 288.5 nM
 Bioactivity Info 
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CP0423360
 Compound Info 
5-chloro-2-N-pyridin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1
IC50 = 294 nM
 Bioactivity Info 
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CP0570196
 Compound Info 
1-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]ethanone
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C28H20F3N5OS
  1
1
IC50 = 307.5 nM
 Bioactivity Info 
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CP0570194
 Compound Info 
4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide
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C27H19F3N6OS
  1
1
IC50 = 357.1 nM
 Bioactivity Info 
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CP0423363
 Compound Info 
1-[4-[6-[[5-chloro-4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanone
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C22H21ClF3N7O
  1
1
IC50 = 660 nM
 Bioactivity Info 
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CP0132336
 Compound Info 
5-chloro-2-N-phenyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H12ClF3N4
  1
1
IC50 = 678 nM
 Bioactivity Info 
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CP0547759
 Compound Info 
5-chloro-2-N-[5-(4-cyclopropylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C23H23ClF3N7
  1
1
IC50 = 712 nM
 Bioactivity Info 
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CP0564774
 Compound Info 
5-chloro-2-N-(4-fluorophenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H11ClF4N4
  1
1
IC50 = 992 nM
 Bioactivity Info 
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CP0176687
 Compound Info 
5-chloro-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H22ClF3N6
  1
1
IC50 = 1005 nM
 Bioactivity Info 
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CP0317797
 Compound Info 
5-chloro-2-N-phenyl-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C17H12ClF3N4O
  1
1
IC50 = 1050 nM
 Bioactivity Info 
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CP0138712
 Compound Info 
5-chloro-2-N-cyclohexyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H18ClF3N4
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0278696
 Compound Info 
5-chloro-2-N-pyridin-4-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0418919
 Compound Info 
5-chloro-2-N-(5-thiomorpholin-4-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H18ClF3N6S
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0480252
 Compound Info 
5-chloro-2-N-pyrimidin-5-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C15H10ClF3N6
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0548497
 Compound Info 
5-chloro-2-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16ClF3N6O
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0553140
 Compound Info 
5-chloro-2-N-(3-phenylpropyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H18ClF3N4
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0572351
 Compound Info 
5-chloro-2-N-pyridazin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C15H10ClF3N6
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0569747
 Compound Info 
5-(1-methylpyrazol-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H18F3N7S
  1
1
IC50 > 3000 nM
 Bioactivity Info 
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CP0545105
 Compound Info 
5-(3-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C26H17ClF3N5S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0545106
 Compound Info 
5-[4-(4-methylpiperazin-1-yl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C31H28F3N7S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0546669
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyrazin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C19H12ClF3N6S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0546696
 Compound Info 
5-(4-aminophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C26H19F3N6S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0546698
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyrimidin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C19H12ClF3N6S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0550070
 Compound Info 
5-phenyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H18F3N5S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0550071
 Compound Info 
N-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide
   Show/Hide
C28H21F3N6OS
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0568836
 Compound Info 
5-chloro-2-N-[5-(furan-2-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C20H13ClF3N5O
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0570409
 Compound Info 
3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide
   Show/Hide
C27H19F3N6OS
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0571825
 Compound Info 
5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C32H30F3N7S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0576815
 Compound Info 
5-chloro-2-N-(4-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C21H14ClF3N4S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0576854
 Compound Info 
5-(4-methylsulfonylphenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C27H20F3N5O2S2
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0579188
 Compound Info 
5-pyridin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C25H17F3N6S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0579317
 Compound Info 
5-(furan-3-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C24H16F3N5OS
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0579318
 Compound Info 
5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H23F3N6S
  1
1
IC50 > 5000 nM
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Cell Line ID: CL000100 , U-937
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0205325
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(1-methyl-2-oxo-3H-indol-6-yl)phenyl]ethyl]oxane-4-carboxamide
   Show/Hide
C24H26N4O3
  1
1 IC50 = 0.2512 nM
CP0241083
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(3-methylsulfonylphenyl)phenyl]ethyl]oxane-4-carboxamide
   Show/Hide
C22H25N3O4S
  1
1 IC50 = 0.7943 nM
CP0157176
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]oxane-4-carboxamide
   Show/Hide
C22H22N4O2
  4
1 IC50 = 0.7943 nM
2 IC50 = 1 nM
3 IC50 = 2.9 nM
4 IC50 = 5 nM
CP0058214
 Compound Info 
(S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)butanamide
   Show/Hide
C19H21N3O
  2
1 IC50 = 1.995 nM
2 IC50 = 13 nM
CP0086671
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]oxane-4-carboxamide
   Show/Hide
C21H23N3O2
  1
1 IC50 = 1.995 nM
CP0086670
 Compound Info 
1-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide
   Show/Hide
C23H24N4O
  1
1 IC50 = 2.512 nM
CP0553111
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzothiazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C23H24N4O3S
  1
1 IC50 = 2.512 nM
CP0061789
 Compound Info 
(2S,4S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide
   Show/Hide
C24H26N4O3
  1
1 IC50 = 3.981 nM
CP0116659
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyano-3-methylsulfanylphenyl)phenyl]ethyl]piperidine-2-carboxamide
   Show/Hide
C23H24N4OS
  1
1 IC50 = 3.981 nM
CP0089882
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C23H24N4O4
  3
1 IC50 = 3.981 nM
2 IC50 = 19.4 nM
3 Kd = 2.512 nM
CP0116666
 Compound Info 
(2S,4S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamide
   Show/Hide
C22H22N4O2
  1
1 IC50 = 5.012 nM
CP0156622
 Compound Info 
4-amino-N-[(1S)-1-cyano-2-[4-(2-methyl-3-oxo-1H-isoindol-5-yl)phenyl]ethyl]oxane-4-carboxamide
   Show/Hide
C24H26N4O3
  1
1 IC50 = 5.012 nM
CP0296065
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3-ethyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C24H26N4O4
  1
1 IC50 = 5.012 nM
CP0196611
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-[3-(2,2-difluoroethyl)-2-oxo-1,3-benzoxazol-5-yl]phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C24H24F2N4O4
  1
1 IC50 = 6.31 nM
CP0307248
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3,7-dimethyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C24H26N4O4
  1
1 IC50 = 10 nM
CP0296066
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-methyl-3-oxo-1,4-benzoxazin-6-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C24H26N4O4
  1
1 IC50 = 12.59 nM
CP0454733
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(1-methyl-2-oxoquinolin-7-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C25H26N4O3
  1
1 IC50 = 12.59 nM
CP0196615
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3,3-difluoro-1-methyl-2-oxoindol-6-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C24H24F2N4O3
  1
1 IC50 = 15.85 nM
CP0398698
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-1,2-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
   Show/Hide
C23H24N4O3
  1
1 IC50 = 15.85 nM
CP0168574
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]piperidine-2-carboxamide
   Show/Hide
C24H26N4O2
  1
1 IC50 = 25.12 nM
CP0351089
 Compound Info 
5-chloro-2-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C23H25ClF3N7
  1
1 IC50 = 32.5 nM
CP0086664
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-2-carboxamide
   Show/Hide
C22H22N4O
  1
1 IC50 = 39.81 nM
CP0196610
 Compound Info 
(1R,2S)-2-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cycloheptane-1-carboxamide
   Show/Hide
C24H26N4O
  1
1 IC50 = 39.81 nM
CP0231221
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
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C22H22N4O2
  1
1 IC50 = 39.81 nM
CP0231222
 Compound Info 
(1R,2S)-2-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide
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C23H24N4O
  1
1 IC50 = 39.81 nM
CP0517068
 Compound Info 
2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H14F3N5S
  1
1 IC50 = 53.1 nM
CP0568246
 Compound Info 
4-N-(4-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H15ClN6S
  1
1 IC50 = 57 nM
CP0245065
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1 IC50 = 57.2 nM
CP0245064
 Compound Info 
5-chloro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1 IC50 = 57.4 nM
CP0351029
 Compound Info 
5-fluoro-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21F4N7
  1
1 IC50 = 57.4 nM
CP0423361
 Compound Info 
5-chloro-2-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H23ClF3N7
  1
1 IC50 = 58.2 nM
CP0545107
 Compound Info 
N-[3-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide
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C21H17ClN6OS
  1
1 IC50 = 59.9 nM
CP0546699
 Compound Info 
N-[4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide
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C28H21F3N6OS
  1
1 IC50 = 61.8 nM
CP0451163
 Compound Info 
5-chloro-2-N-[5-[4-(dimethylamino)phenyl]pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H20ClF3N6
  1
1 IC50 = 62.2 nM
CP0579868
 Compound Info 
5-chloro-2-N-(3-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H14ClF3N4S
  1
1 IC50 = 65.6 nM
CP0480229
 Compound Info 
5-fluoro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13F4N5S
  1
1 IC50 = 66.2 nM
CP0576984
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-diamine
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C21H15ClF3N5S
  1
1 IC50 = 69.4 nM
CP0578761
 Compound Info 
N-[4-[[5-chloro-2-[(5-thiophen-3-ylpyridin-2-yl)amino]pyrimidin-4-yl]amino]phenyl]acetamide
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C21H17ClN6OS
  1
1 IC50 = 76.4 nM
CP0546695
 Compound Info 
5-chloro-2-N-(4-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1 IC50 = 77.9 nM
CP0138583
 Compound Info 
5-chloro-2-N-(5-piperazin-1-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H19ClF3N7
  1
1 IC50 = 78.7 nM
CP0176739
 Compound Info 
5-chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine
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C22H21ClF3N5O
  1
1 IC50 = 82.4 nM
CP0423364
 Compound Info 
2-N-[5-(4-aminopiperidin-1-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1 IC50 = 86.5 nM
CP0546700
 Compound Info 
5-chloro-2-N-(6-thiophen-3-ylpyridazin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C19H12ClF3N6S
  1
1 IC50 = 90.6 nM
CP0576814
 Compound Info 
5-chloro-4-N-piperidin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C18H19ClN6S
  1
1 IC50 = 91.5 nM
CP0564775
 Compound Info 
5-chloro-2-N-[5-(4-propylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C23H25ClF3N7
  1
1 IC50 = 92 nM
CP0569746
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5OS
  1
1 IC50 = 92.4 nM
CP0176738
 Compound Info 
5-chloro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[3-(trifluoromethyl)phenoxy]pyrimidin-2-amine
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C21H20ClF3N6O
  1
1 IC50 = 94 nM
CP0579319
 Compound Info 
5-bromo-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13BrF3N5S
  1
1 IC50 = 98.6 nM
CP0546852
 Compound Info 
5-chloro-4-N-(3,4-difluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H12ClF2N5S
  1
1 IC50 = 99.8 nM
CP0570172
 Compound Info 
5-chloro-4-N-pyridin-2-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C18H13ClN6S
  1
1 IC50 = 102.5 nM
CP0550068
 Compound Info 
5-chloro-2-N-(6-thiophen-3-ylpyridin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1 IC50 = 102.8 nM
CP0579315
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1 IC50 = 104.7 nM
CP0444643
 Compound Info 
5-methyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16F3N5S
  1
1 IC50 = 109 nM
CP0561721
 Compound Info 
5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H20ClF3N8
  1
1 IC50 = 115 nM
CP0247122
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]piperidine-2-carboxamide
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C21H23N3O
  1
1 IC50 = 125.89 nM
CP0578309
 Compound Info 
5-chloro-4-N-(4-fluorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H13ClFN5S
  1
1 IC50 = 127.5 nM
CP0545103
 Compound Info 
5-chloro-2-N-(5-thiophen-2-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5S
  1
1 IC50 = 127.6 nM
CP0545104
 Compound Info 
4-N-(3-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C19H15ClN6S
  1
1 IC50 = 132.5 nM
CP0570194
 Compound Info 
4-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide
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C27H19F3N6OS
  1
1 IC50 = 132.7 nM
CP0480230
 Compound Info 
5-methoxy-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16F3N5OS
  1
1 IC50 = 133 nM
CP0351352
 Compound Info 
5-chloro-2-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H21ClF3N7
  1
1 IC50 = 136 nM
CP0176687
 Compound Info 
5-chloro-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H22ClF3N6
  1
1 IC50 = 142 nM
CP0576853
 Compound Info 
5-chloro-4-N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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C20H12ClF4N5S
  1
1 IC50 = 142.5 nM
CP0578307
 Compound Info 
5-chloro-2-N-(3-nitro-5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H12ClF3N6O2S
  1
1 IC50 = 152.4 nM
CP0570196
 Compound Info 
1-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]ethanone
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C28H20F3N5OS
  1
1 IC50 = 155.7 nM
CP0132348
 Compound Info 
2-N-[5-(4-aminophenyl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H16ClF3N6
  1
1 IC50 = 158 nM
CP0176737
 Compound Info 
5-methoxy-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H24F3N7O
  1
1 IC50 = 179 nM
CP0556743
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]ethyl]-1,4-oxazepane-2-carboxamide
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C20H20F3N5O2
  1
1 IC50 = 199.53 nM
CP0423362
 Compound Info 
2-N-[5-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)pyridin-2-yl]-5-chloro-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H25ClF3N7
  1
1 IC50 = 202 nM
CP0561798
 Compound Info 
5-chloro-2-N-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H20ClF3N8
  1
1 IC50 = 207 nM
CP0517067
 Compound Info 
5-methyl-2-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H24F3N7
  1
1 IC50 = 210 nM
CP0132347
 Compound Info 
5-chloro-2-N-(5-phenylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C22H15ClF3N5
  1
1 IC50 = 214 nM
CP0576816
 Compound Info 
5-(4-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H17ClF3N5S
  1
1 IC50 = 215.7 nM
CP0569747
 Compound Info 
5-(1-methylpyrazol-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H18F3N7S
  1
1 IC50 = 247.6 nM
CP0579313
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5OS
  1
1 IC50 = 251.7 nM
CP0451145
 Compound Info 
5-chloro-2-N-pyridin-2-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1 IC50 = 296 nM
CP0444642
 Compound Info 
5-chloro-2-N-[5-(1-methylpyrazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H15ClF3N7
  1
1 IC50 = 305 nM
CP0423363
 Compound Info 
1-[4-[6-[[5-chloro-4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanone
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C22H21ClF3N7O
  1
1 IC50 = 308 nM
CP0327068
 Compound Info 
(1R,2R)-2-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide
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C23H24N4O
  1
1 IC50 = 316.23 nM
CP0048199
 Compound Info 
(2S)-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]morpholine-2-carboxamide
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C21H20N4O2
  1
1 IC50 = 398.11 nM
CP0418919
 Compound Info 
5-chloro-2-N-(5-thiomorpholin-4-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H18ClF3N6S
  1
1 IC50 = 408 nM
CP0423360
 Compound Info 
5-chloro-2-N-pyridin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1 IC50 = 417 nM
CP0327069
 Compound Info 
(1S,2S)-2-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamide
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C23H24N4O
  1
1 IC50 = 501.19 nM
CP0132336
 Compound Info 
5-chloro-2-N-phenyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H12ClF3N4
  1
1 IC50 = 678 nM
CP0564774
 Compound Info 
5-chloro-2-N-(4-fluorophenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H11ClF4N4
  1
1 IC50 = 785 nM
CP0547759
 Compound Info 
5-chloro-2-N-[5-(4-cyclopropylpiperazin-1-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C23H23ClF3N7
  1
1 IC50 = 982 nM
CP0317797
 Compound Info 
5-chloro-2-N-phenyl-4-N-[3-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
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C17H12ClF3N4O
  1
1 IC50 = 985 nM
CP0354140
 Compound Info 
(1R,2S)-2-amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclopentane-1-carboxamide
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C22H22N4O
  1
1 IC50 = 1000 nM
CP0048198
 Compound Info 
N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]azepane-3-carboxamide
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C23H24N4O
  1
1 IC50 = 1258.93 nM
CP0572351
 Compound Info 
5-chloro-2-N-pyridazin-3-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C15H10ClF3N6
  1
1 IC50 = 1561 nM
CP0480252
 Compound Info 
5-chloro-2-N-pyrimidin-5-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C15H10ClF3N6
  1
1 IC50 = 1990 nM
CP0553140
 Compound Info 
5-chloro-2-N-(3-phenylpropyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H18ClF3N4
  1
1 IC50 = 2022 nM
CP0138712
 Compound Info 
5-chloro-2-N-cyclohexyl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C17H18ClF3N4
  1
1 IC50 = 2625 nM
CP0278696
 Compound Info 
5-chloro-2-N-pyridin-4-yl-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C16H11ClF3N5
  1
1 IC50 = 2989 nM
CP0548497
 Compound Info 
5-chloro-2-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C21H16ClF3N6O
  1
1 IC50 > 5000 nM
CP0545105
 Compound Info 
5-(3-chlorophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H17ClF3N5S
  1
1 IC50 > 5000 nM
CP0545106
 Compound Info 
5-[4-(4-methylpiperazin-1-yl)phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C31H28F3N7S
  1
1 IC50 > 5000 nM
CP0546669
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyrazin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C19H12ClF3N6S
  1
1 IC50 > 5000 nM
CP0546696
 Compound Info 
5-(4-aminophenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C26H19F3N6S
  1
1 IC50 > 5000 nM
CP0546698
 Compound Info 
5-chloro-2-N-(5-thiophen-3-ylpyrimidin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C19H12ClF3N6S
  1
1 IC50 > 5000 nM
CP0550070
 Compound Info 
5-phenyl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H18F3N5S
  1
1 IC50 > 5000 nM
CP0550071
 Compound Info 
N-[3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]phenyl]acetamide
   Show/Hide
C28H21F3N6OS
  1
1 IC50 > 5000 nM
CP0568836
 Compound Info 
5-chloro-2-N-[5-(furan-2-yl)pyridin-2-yl]-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C20H13ClF3N5O
  1
1 IC50 > 5000 nM
CP0570409
 Compound Info 
3-[2-[(5-thiophen-3-ylpyridin-2-yl)amino]-4-[3-(trifluoromethyl)anilino]pyrimidin-5-yl]benzamide
   Show/Hide
C27H19F3N6OS
  1
1 IC50 > 5000 nM
CP0571825
 Compound Info 
5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C32H30F3N7S
  1
1 IC50 > 5000 nM
CP0576815
 Compound Info 
5-chloro-2-N-(4-thiophen-3-ylphenyl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C21H14ClF3N4S
  1
1 IC50 > 5000 nM
CP0576854
 Compound Info 
5-(4-methylsulfonylphenyl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C27H20F3N5O2S2
  1
1 IC50 > 5000 nM
CP0579188
 Compound Info 
5-pyridin-4-yl-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C25H17F3N6S
  1
1 IC50 > 5000 nM
CP0579317
 Compound Info 
5-(furan-3-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C24H16F3N5OS
  1
1 IC50 > 5000 nM
CP0579318
 Compound Info 
5-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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C26H23F3N6S
  1
1 IC50 > 5000 nM
Clinical Information about the Protein
Target 1 ( Dipeptidyl peptidase I (CTSC) )
Target Type Clinical trial Target
Target 2 ( HUMAN dipeptidyl peptidase 1 (CTSC) )
Target Type Unknown Type Target
Disease 1 Target-related Disease  1
1 Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y]
Preclinical Drug(s) 1 Preclinical Drug  1
1 Brensocatib
 Drug Info 
Preclinical
Coronavirus Disease 2019 (COVID-19)