General Information of the Compound
Compound ID
CP0550068
Compound Name
5-chloro-2-N-(6-thiophen-3-ylpyridin-3-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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Structure
Formula
C20H13ClF3N5S
Molecular Weight
447.873
Canonical SMILES
FC(F)(F)c1cccc(Nc2nc(Nc3ccc(nc3)-c3ccsc3)ncc2Cl)c1
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InChI
InChI=1S/C20H13ClF3N5S/c21-16-10-26-19(28-15-4-5-17(25-9-15)12-6-7-30-11-12)29-18(16)27-14-3-1-2-13(8-14)20(22,23)24/h1-11H,(H2,26,27,28,29)
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InChIKey
CMLIHNXRVQWYBQ-UHFFFAOYSA-N
Physicochemical Property
logP
6.7595
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
62.73
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168269572
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02790, Dipeptidyl peptidase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 159.6 nM
   TI
   LI
   LO
   TS
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 215.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 102.8 nM