Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-N-(4-aminophenyl)-5-chloro-2-N-(5-thiophen-3-ylpyridin-2-yl)pyrimidine-2,4-diamine
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 PubChem ID
CID: 168289983
Canonical SMILES
Nc1ccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)cc1
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Compound Formula C19H15ClN6S
Compound Structure
Protein Name
 Protein Info 
Dipeptidyl peptidase 1
Protein Classification
Enzyme
>
Protease
>
Cysteine protease
>
Cysteine protease CA clan
>
Cysteine protease C1A family
Uniprot ID
P53634
Gene Name
CTSC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 110.7 nM
   TI
   LI
   LO
   TS
CL000100 U-937
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 89.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 57 nM