General Information of the Compound
Compound ID
CP0529931
Compound Name
N-[5-[6-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-(4-methylpiperazin-1-yl)pyridin-2-yl]oxy-2-methylphenyl]prop-2-enamide
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Structure
Formula
C32H41N7O3
Molecular Weight
571.726
Canonical SMILES
COc1cc(ccc1Nc1ccc(N2CCN(C)CC2)c(Oc2ccc(C)c(NC(=O)C=C)c2)n1)N1CCN(C)CC1
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InChI
InChI=1S/C32H41N7O3/c1-6-31(40)34-27-22-25(9-7-23(27)2)42-32-28(39-19-15-37(4)16-20-39)11-12-30(35-32)33-26-10-8-24(21-29(26)41-5)38-17-13-36(3)14-18-38/h6-12,21-22H,1,13-20H2,2-5H3,(H,33,35)(H,34,40)
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InChIKey
NLNKYGYNCGYYSC-UHFFFAOYSA-N
Physicochemical Property
logP
4.56262
Rotatable Bonds
9
Heavy Atom Count
42
Polar Areas
85.44
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 151217326
ChEMBL ID
CHEMBL4541754
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02790, Dipeptidyl peptidase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS