General Information of the Compound
Compound ID
CP0579317
Compound Name
5-(furan-3-yl)-2-N-(5-thiophen-3-ylpyridin-2-yl)-4-N-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine
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Structure
Formula
C24H16F3N5OS
Molecular Weight
479.487
Canonical SMILES
FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2-c2ccoc2)c1
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InChI
InChI=1S/C24H16F3N5OS/c25-24(26,27)18-2-1-3-19(10-18)30-22-20(16-6-8-33-13-16)12-29-23(32-22)31-21-5-4-15(11-28-21)17-7-9-34-14-17/h1-14H,(H2,28,29,30,31,32)
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InChIKey
KGYNDHCZUUPUDB-UHFFFAOYSA-N
Physicochemical Property
logP
7.3661
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
75.87
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168271118
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02790, Dipeptidyl peptidase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 > 5000 nM