Protein Information

General Information of the Protein

Protein ID	PT01021
Protein Name	C-C chemokine receptor type 2
Secondarily Protein Name	Monocyte chemoattractant protein 1 receptor
Gene Name	CCR2
Secondarily Gene Name	CMKBR2
Sequence	MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Chemokine receptor > CC chemokine receptor
Function	Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). Show/Hide
Uniprot ID	Primary ID: P41597 Secondarily ID: A0AVQ3 B2RMT0 O95950 Q4VBL2 Show/Hide
Ensembl ID	ENSG00000121807
HGNC ID	HGNC:1603
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0315991 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-ethyl tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0053417 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H29F9N2O2	2
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5.5 nM Bioactivity Info	TI LI LO TS
CP0425145 Compound Info	(1S,3R)-1-cyclopropyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C31H34F4N2O	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0390911 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(cyclopropylmethyl)-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C31H34F6N2O	2
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0444505 Compound Info	(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide Show/Hide	C31H36F4N2O	1
1	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
CP0437369 Compound Info	1-ethyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C30H34F4N2O	1
1	IC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0900717 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(oxetan-3-ylamino)cyclopentanecarboxamide trifluoroacetate salt Show/Hide	C23H27F9N2O4	1
1	IC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0525772 Compound Info	(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide Show/Hide	C30H34F4N2OS	1
1	IC50 = 3.5 nM Bioactivity Info	TI LI LO TS
CP0428650 Compound Info	(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C32H38F4N2O	1
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0373631 Compound Info	(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C29H32F4N2O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0041927 Compound Info	(2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopropyl-4-[(1R,3R')-3'methyl-1'H-spiro[indene-1,4'-piperidin]-1'yl]butanamide Show/Hide	C30H32F6N2O	2
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0165577 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2O2	1
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
CP0522581 Compound Info	N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide Show/Hide	C31H36F4N2O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0522786 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-propyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C26H36F6N2O2	2
1	IC50 = 5.1 nM Bioactivity Info	TI LI LO TS
2	IC50 = 7.8 nM Bioactivity Info	TI LI LO TS
CP0425146 Compound Info	1-(cyclopropylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C32H36F4N2O	1
1	IC50 = 5.5 nM Bioactivity Info	TI LI LO TS
CP0871032 Compound Info	CENICRIVIROC MESYLATE Show/Hide	C42H56N4O7S2	1
1	IC50 = 5.9 nM Bioactivity Info	TI LI LO TS
CP0535185 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-cyclopropyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C32H34F6N2O	1
1	IC50 = 6.5 nM Bioactivity Info	TI LI LO TS
CP0053416 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,5-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0442366 Compound Info	(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide Show/Hide	C32H36F6N2O	1
1	IC50 = 7.6 nM Bioactivity Info	TI LI LO TS
CP0496763 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-((3-(dimethylamino)propyl)(methyl)amino)-2-phenylacetamide Show/Hide	C23H27F6N3O	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0437367 Compound Info	(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C33H38F6N2O	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0522580 Compound Info	N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C30H34F4N2O2	1
1	IC50 = 8.5 nM Bioactivity Info	TI LI LO TS
CP0437368 Compound Info	(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C30H32F6N2O	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0920191 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(3-(dimethylamino)propylideneamino)-2-phenylacetamide Show/Hide	C22H23F6N3O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0428649 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-ethyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C31H34F6N2O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0395332 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclobutyl-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C31H34F6N2O	2
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0428042 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-5-(dimethylamino)-2-phenylpentanamide Show/Hide	C22H24F6N2O	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0428698 Compound Info	(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide Show/Hide	C31H34F6N2OS	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0535186 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C31H34F6N2O2	1
1	IC50 = 15.5 nM Bioactivity Info	TI LI LO TS
CP0420176 Compound Info	(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide Show/Hide	C32H36F6N2O	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0507891 Compound Info	US8906911, 64 Show/Hide	C26H35F3N4O2	2
1	IC50 = 16.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0565604 Compound Info	US8906911, 46 Show/Hide	C27H35ClF3N3O3	2
1	IC50 = 17.6 nM Bioactivity Info	TI LI LO TS
2	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0428169 Compound Info	US8906911, 63 Show/Hide	C26H35F3N4O2	2
1	IC50 = 17.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0428648 Compound Info	(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(cyclobutylmethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C34H38F6N2O	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0518546 Compound Info	US8906911, 28 Show/Hide	C28H35F3N4O3	2
1	IC50 = 19.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0427178 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(cyclopropylmethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C33H36F6N2O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0440375 Compound Info	(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C29H30F6N2O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0238399 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-thiopyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2OS	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0496758 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylthio)-2-phenylacetamide Show/Hide	C21H22F6N2OS	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0562154 Compound Info	US8906911, 50 Show/Hide	C28H35F6N3O3	2
1	IC50 = 25.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 78 nM Bioactivity Info	TI LI LO TS
CP0373628 Compound Info	N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C34H42F4N2O	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0666580 Compound Info	Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium chloride(TAK-779) Show/Hide	C33H39ClN2O2	3
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
2	IC50 = 28 nM Bioactivity Info	TI LI LO TS
3	Ki = 4.169 nM Bioactivity Info	TI LI LO TS
CP0433968 Compound Info	(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide Show/Hide	C30H32F6N2OS	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0467606 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(2-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0468216 Compound Info	US8906911, 65 Show/Hide	C27H37F3N4O2	2
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
2	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0302119 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(oxepan-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0532438 Compound Info	1'-{2-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]ethyl}-6-methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one Show/Hide	C24H24FN3O3	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0515439 Compound Info	US8906911, 6 Show/Hide	C25H34F3N5O3	2
1	IC50 = 32.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0562153 Compound Info	US8906911, 15 Show/Hide	C27H35F4N3O3	2
1	IC50 = 34.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 29 nM Bioactivity Info	TI LI LO TS
CP0315992 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrothiophen-3-ylamino)cyclopentanecarboxamide Show/Hide	C22H28F6N2OS	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0557635 Compound Info	US8906911, 49 Show/Hide	C31H37F3N4O	2
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
2	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0145835 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piperidin-1-yl)ethylamino)-2-(thiophen-3-yl)acetamide Show/Hide	C22H25F6N3OS	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0400725 Compound Info	US8906911, 40 Show/Hide	C26H35Cl2N3O3	2
1	IC50 = 41.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 38 nM Bioactivity Info	TI LI LO TS
CP0468205 Compound Info	US8906911, 14 Show/Hide	C27H35F4N3O3	2
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
2	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0563848 Compound Info	US8906911, 51 Show/Hide	C28H37ClF3N3O3	2
1	IC50 = 43.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 21 nM Bioactivity Info	TI LI LO TS
CP0538110 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-{5'-methylspiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C33H31F7N2O	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0561490 Compound Info	US8906911, 66 Show/Hide	C27H37F3N4O2	2
1	IC50 = 45.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0507889 Compound Info	US8906911, 56 Show/Hide	C29H37F3N4O3	2
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
2	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0516781 Compound Info	US8906911, 53 Show/Hide	C29H37F3N4O3	2
1	IC50 = 47.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0507888 Compound Info	US8906911, 47 Show/Hide	C27H35ClN4O3	2
1	IC50 = 49.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 77 nM Bioactivity Info	TI LI LO TS
CP0165576 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxytetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C23H30F6N2O3	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0516780 Compound Info	US8906911, 48 Show/Hide	C33H37F3N4O	2
1	IC50 = 51.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 8 nM Bioactivity Info	TI LI LO TS
CP0518544 Compound Info	US8906911, 1 Show/Hide	C26H35F3N4O3	2
1	IC50 = 54.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0517169 Compound Info	US8906911, 39 Show/Hide	C28H35F3N4O3	2
1	IC50 = 55.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 66 nM Bioactivity Info	TI LI LO TS
CP0514673 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-3-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2O2	1
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0285420 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C33H31F7N2O	2
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
2	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0165578 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclohexylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C24H32F6N2O	1
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0561511 Compound Info	US8906911, 7 Show/Hide	C27H37F3N4O3	2
1	IC50 = 65.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 30 nM Bioactivity Info	TI LI LO TS
CP0505434 Compound Info	(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide Show/Hide	C29H32F4N2OS	1
1	IC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0390625 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-cyclopropyl-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide Show/Hide	C29H30F6N2O	1
1	IC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0419277 Compound Info	US8906911, 18 Show/Hide	C27H36F3N3O3	2
1	IC50 = 76.4 nM Bioactivity Info	TI LI LO TS
2	Ki = 207 nM Bioactivity Info	TI LI LO TS
CP0562152 Compound Info	US8906911, 2 Show/Hide	C26H35F3N4O3	2
1	IC50 = 76.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 60 nM Bioactivity Info	TI LI LO TS
CP0331716 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C27H30F6N2O	1
1	IC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0277808 Compound Info	(2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4-(1'H-spiro[indene-1,4'-piperidin]-1'yl)butanamide Show/Hide	C32H29F7N2O	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0467334 Compound Info	(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclopropyl-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C30H32F6N2O	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0428168 Compound Info	US8906911, 52 Show/Hide	C29H37F6N3O3	2
1	IC50 = 83.9 nM Bioactivity Info	TI LI LO TS
2	Ki = 49 nM Bioactivity Info	TI LI LO TS
CP0315993 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrofuran-3-ylamino)cyclopentanecarboxamide Show/Hide	C22H28F6N2O2	1
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0532188 Compound Info	US8906911, 25 Show/Hide	C27H35F4N3O3	2
1	IC50 = 92.2 nM Bioactivity Info	TI LI LO TS
2	Ki = 271 nM Bioactivity Info	TI LI LO TS
CP0513407 Compound Info	US8906911, 30 Show/Hide	C24H33F3N4O3S	2
1	IC50 = 95.5 nM Bioactivity Info	TI LI LO TS
2	Ki = 831 nM Bioactivity Info	TI LI LO TS
CP0485249 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclopropyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C29H30F6N2O	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0517482 Compound Info	US8906911, 61 Show/Hide	C26H35F3N4O2	2
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
2	Ki = 69 nM Bioactivity Info	TI LI LO TS
CP0468206 Compound Info	US8906911, 16 Show/Hide	C28H38F3N3O3	2
1	IC50 = 106 nM Bioactivity Info	TI LI LO TS
2	Ki = 199 nM Bioactivity Info	TI LI LO TS
CP0527600 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-[(1S,5'S)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C33H31F7N2O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0388120 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-cyclopropyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C26H34F6N2O2	1
1	IC50 = 123 nM Bioactivity Info	TI LI LO TS
CP0443065 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-yl-2-(trifluoromethylsulfonylamino)butanamide Show/Hide	C27H26F9N3O3S	1
1	IC50 = 125 nM Bioactivity Info	TI LI LO TS
CP0386030 Compound Info	(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phenylpiperidin-1-yl)ethyl)pentanamide Show/Hide	C27H32F6N2O	1
1	IC50 = 126 nM Bioactivity Info	TI LI LO TS
CP0522378 Compound Info	(2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(4-fluorophenyl)-4-[(3R,4S)-3-methyl-4-phenylpiperidin-1-yl]butan-1-amine Show/Hide	C31H33F7N2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0513440 Compound Info	US8906911, 5 Show/Hide	C25H34F3N5O3	2
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
2	Ki = 104 nM Bioactivity Info	TI LI LO TS
CP0468208 Compound Info	US8906911, 29 Show/Hide	C27H36F3N3O4	2
1	IC50 = 148 nM Bioactivity Info	TI LI LO TS
2	Ki = 473 nM Bioactivity Info	TI LI LO TS
CP0171015 Compound Info	(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide Show/Hide	C30H29F7N2O	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0532187 Compound Info	US8906911, 22 Show/Hide	C26H35F3N4O3	2
1	IC50 = 153 nM Bioactivity Info	TI LI LO TS
2	Ki = 120 nM Bioactivity Info	TI LI LO TS
CP0340173 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclopentylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C23H30F6N2O	1
1	IC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0441645 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-(thiophen-3-yl)piperidin-1-yl)butanamide Show/Hide	C28H27F7N2OS	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0376674 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-cyclohexyl-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide Show/Hide	C32H36F6N2O	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0428073 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-[(1R,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide Show/Hide	C27H28F6N2O	1
1	IC50 = 173 nM Bioactivity Info	TI LI LO TS
CP0512376 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-2-(2-(piperidin-1-yl)ethylamino)acetamide Show/Hide	C24H26F7N3O	2
1	IC50 = 175 nM Bioactivity Info	TI LI LO TS
2	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0481537 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cycloheptylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O	1
1	IC50 = 175 nM Bioactivity Info	TI LI LO TS
CP0555435 Compound Info	US8906911, 20 Show/Hide	C26H35ClFN3O3	2
1	IC50 = 182 nM Bioactivity Info	TI LI LO TS
2	Ki = 112 nM Bioactivity Info	TI LI LO TS
CP0468412 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-2-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C27H30F6N2O	1
1	IC50 = 187 nM Bioactivity Info	TI LI LO TS
CP0467333 Compound Info	(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)pent-4-enamide Show/Hide	C29H30F6N2O	1
1	IC50 = 193 nM Bioactivity Info	TI LI LO TS
CP0282451 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclobutylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C22H28F6N2O	1
1	IC50 = 193 nM Bioactivity Info	TI LI LO TS
CP0565014 Compound Info	US8906911, 12 Show/Hide	C25H34F3N5O3	2
1	IC50 = 194 nM Bioactivity Info	TI LI LO TS
2	Ki = 261 nM Bioactivity Info	TI LI LO TS
CP0505625 Compound Info	2-amino-N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methylamino]-2-oxoethyl]-5-(trifluoromethyl)benzamide Show/Hide	C23H26ClF3N4O2	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0536582 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-methyl-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)butanamide Show/Hide	C29H32F6N2O	1
1	IC50 = 204 nM Bioactivity Info	TI LI LO TS
CP0522282 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(piperidin-1-yl)ethylamino)acetamide Show/Hide	C24H27F6N3O	2
1	IC50 = 219 nM Bioactivity Info	TI LI LO TS
2	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0493802 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,3-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0433969 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide Show/Hide	C35H42F6N2O	1
1	IC50 = 231 nM Bioactivity Info	TI LI LO TS
CP0536581 Compound Info	(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C27H28F6N2O	1
1	IC50 = 231 nM Bioactivity Info	TI LI LO TS
CP0518545 Compound Info	US8906911, 19 Show/Hide	C28H38F3N3O3	2
1	IC50 = 233 nM Bioactivity Info	TI LI LO TS
2	Ki = 306 nM Bioactivity Info	TI LI LO TS
CP0459575 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(1,2,3,4-tetrahydronaphthalen-2-ylamino)cyclopentanecarboxamide Show/Hide	C28H32F6N2O	1
1	IC50 = 239 nM Bioactivity Info	TI LI LO TS
CP0541313 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(methanesulfonamido)-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide Show/Hide	C27H29F6N3O3S	1
1	IC50 = 244 nM Bioactivity Info	TI LI LO TS
CP0453043 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cyclopropyl-4-(4-(4-fluorophenyl)piperidin-1-yl)butanamide Show/Hide	C27H29F7N2O	1
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0456460 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cyclopropyl-4-(4-phenylpiperidin-1-yl)butanamide Show/Hide	C27H30F6N2O	1
1	IC50 = 285 nM Bioactivity Info	TI LI LO TS
CP0439634 Compound Info	2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C33H32F6N2O	1
1	IC50 = 298 nM Bioactivity Info	TI LI LO TS
CP0518547 Compound Info	US8906911, 36 Show/Hide	C28H35F3N4O3	2
1	IC50 = 305 nM Bioactivity Info	TI LI LO TS
2	Ki = 1060 nM Bioactivity Info	TI LI LO TS
CP0468210 Compound Info	US8906911, 32 Show/Hide	C26H34ClF3N4O3	2
1	IC50 = 314 nM Bioactivity Info	TI LI LO TS
2	Ki = 1060 nM Bioactivity Info	TI LI LO TS
CP0496914 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}-2-(4-fluorophenyl)butanamide Show/Hide	C32H31F7N2O	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0468214 Compound Info	US8906911, 60 Show/Hide	C25H41N3O5	2
1	IC50 = 328 nM Bioactivity Info	TI LI LO TS
2	Ki = 552 nM Bioactivity Info	TI LI LO TS
CP0428041 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-phenyl-2-(2-piperidin-1-ylethylamino)acetamide Show/Hide	C24H27F6N3O	1
1	IC50 = 342 nM Bioactivity Info	TI LI LO TS
CP0394052 Compound Info	(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-methyl-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)butanamide Show/Hide	C29H32F6N2O	1
1	IC50 = 349 nM Bioactivity Info	TI LI LO TS
CP0119832 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-((tetrahydro-2H-pyran-4-yl)methylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 362 nM Bioactivity Info	TI LI LO TS
CP0466639 Compound Info	US8906911, 27 Show/Hide	C25H34F3N5O3	2
1	IC50 = 391 nM Bioactivity Info	TI LI LO TS
2	Ki = 444 nM Bioactivity Info	TI LI LO TS
CP0464513 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(azepan-1-yl)ethylamino)-2-phenylacetamide Show/Hide	C25H29F6N3O	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0262145 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(chroman-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C27H30F6N2O2	1
1	IC50 = 419 nM Bioactivity Info	TI LI LO TS
CP0449525 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(thiophen-3-yl)acetamide Show/Hide	C19H21F6N3OS	1
1	IC50 = 424 nM Bioactivity Info	TI LI LO TS
CP0390994 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1R,3'R)-3'-ethylspiro[indene-1,4'-piperidine]-1'-yl]-2-(4-fluorophenyl)butanamide Show/Hide	C34H33F7N2O	1
1	IC50 = 437 nM Bioactivity Info	TI LI LO TS
CP0422297 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{5'-ethylspiro[indene-1,4'-piperidine]-1'-yl}-2-(4-fluorophenyl)butanamide Show/Hide	C34H33F7N2O	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0468215 Compound Info	US8906911, 62 Show/Hide	C26H35F3N4O2	1
1	IC50 = 445 nM Bioactivity Info	TI LI LO TS
CP0556819 Compound Info	US8906911, 9 Show/Hide	C32H37F3N4O3	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0532437 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-phenyl-2-(2-pyrrolidin-1-ylethylamino)acetamide Show/Hide	C23H25F6N3O	1
1	IC50 = 521 nM Bioactivity Info	TI LI LO TS
CP0507890 Compound Info	US8906911, 57 Show/Hide	C29H37F3N4O3	1
1	IC50 = 521 nM Bioactivity Info	TI LI LO TS
CP0528177 Compound Info	N-[1-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-oxo-4-spiro[indene-1,4'-piperidine]-1'-ylbutan-2-yl]-2-oxoimidazolidine-4-carboxamide Show/Hide	C30H31F6N5O3	1
1	IC50 = 525 nM Bioactivity Info	TI LI LO TS
CP0563261 Compound Info	US8906911, 13 Show/Hide	C25H34F3N5O3	2
1	IC50 = 525 nM Bioactivity Info	TI LI LO TS
2	Ki = 593 nM Bioactivity Info	TI LI LO TS
CP0480387 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide Show/Hide	C26H26F6N2O	1
1	IC50 = 570 nM Bioactivity Info	TI LI LO TS
CP0542432 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(2-morpholin-4-ylethylamino)-2-phenylacetamide Show/Hide	C23H25F6N3O2	1
1	IC50 = 575 nM Bioactivity Info	TI LI LO TS
CP0511038 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(dimethylamino)ethylamino]-2-(furan-2-yl)acetamide Show/Hide	C19H21F6N3O2	1
1	IC50 = 592 nM Bioactivity Info	TI LI LO TS
CP0468207 Compound Info	US8906911, 26 Show/Hide	C26H35F3N4O3	2
1	IC50 = 598 nM Bioactivity Info	TI LI LO TS
2	Ki = 792 nM Bioactivity Info	TI LI LO TS
CP0501984 Compound Info	(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C27H28F6N2O	1
1	IC50 = 605 nM Bioactivity Info	TI LI LO TS
CP0388118 Compound Info	(1S,3R)-3-(1,1-Dioxo-hexahydro-1lambda6-thiopyran-4-ylamino)-1-isopropyl-cyclopentanecarboxylic acid 3,5-bis-trifluoromethyl-benzylamide Show/Hide	C23H30F6N2O3S	1
1	IC50 = 631 nM Bioactivity Info	TI LI LO TS
CP0390923 Compound Info	(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phenylpiperidin-1-yl)ethyl)pent-4-enamide Show/Hide	C27H30F6N2O	1
1	IC50 = 642 nM Bioactivity Info	TI LI LO TS
CP0500007 Compound Info	2-(1-acetylpiperidin-3-yl)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide Show/Hide	C33H37F6N3O2	1
1	IC50 = 660 nM Bioactivity Info	TI LI LO TS
CP0464560 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(diethylamino)ethylamino]-2-phenylacetamide Show/Hide	C23H27F6N3O	1
1	IC50 = 678 nM Bioactivity Info	TI LI LO TS
CP0496915 Compound Info	(2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(4-fluorophenyl)-4-[(3S,4S)-3-methyl-4-phenylpiperidin-1-yl]butan-1-amine Show/Hide	C31H33F7N2	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0167324 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(4-fluorophenyl)acetamide Show/Hide	C21H22F7N3O	2
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
2	IC50 = 770 nM Bioactivity Info	TI LI LO TS
CP0464512 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-methylpiperidin-1-yl)ethylamino)-2-phenylacetamide Show/Hide	C25H29F6N3O	1
1	IC50 = 756 nM Bioactivity Info	TI LI LO TS
CP0204218 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxy-3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C24H29F9N2O3	1
1	IC50 = 765 nM Bioactivity Info	TI LI LO TS
CP0515959 Compound Info	(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(3-methyl-4-phenylpiperazin-1-yl)butanamide Show/Hide	C30H30F7N3O	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0536583 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(1-methylsulfonylpiperidin-3-yl)-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide Show/Hide	C32H37F6N3O3S	1
1	IC50 = 783 nM Bioactivity Info	TI LI LO TS
CP0541314 Compound Info	methyl N-[1-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-oxo-4-spiro[indene-1,4'-piperidine]-1'-ylbutan-2-yl]carbamate Show/Hide	C28H29F6N3O3	1
1	IC50 = 805 nM Bioactivity Info	TI LI LO TS
CP0564955 Compound Info	US8906911, 42 Show/Hide	C28H35F3N4O3	1
1	IC50 = 812 nM Bioactivity Info	TI LI LO TS
CP0461573 Compound Info	US8906911, 21 Show/Hide	C26H34F4N4O3	1
1	IC50 = 821 nM Bioactivity Info	TI LI LO TS
CP0501138 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(4-phenylpiperidin-1-yl)ethylamino)acetamide Show/Hide	C30H31F6N3O	2
1	IC50 = 822 nM Bioactivity Info	TI LI LO TS
2	IC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0516783 Compound Info	US8906911, 59 Show/Hide	C24H31F3N4O2	1
1	IC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0542431 Compound Info	(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(2-methylpiperidin-1-yl)ethylamino)-2-phenylacetamide Show/Hide	C25H29F6N3O	1
1	IC50 = 838 nM Bioactivity Info	TI LI LO TS
CP0524406 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(thiophen-2-yl)acetamide Show/Hide	C19H21F6N3OS	1
1	IC50 = 865 nM Bioactivity Info	TI LI LO TS
CP0441644 Compound Info	(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide Show/Hide	C30H29F7N2O	1
1	IC50 = 930 nM Bioactivity Info	TI LI LO TS
CP0442885 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-phenylacetamide Show/Hide	C21H23F6N3O	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0464517 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-5-(piperidin-1-yl)pentanamide Show/Hide	C25H27F7N2O	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0468209 Compound Info	US8906911, 31 Show/Hide	C28H38F3N3O4	1
1	IC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0522377 Compound Info	(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-2-methyl-4-(4-phenylpiperidin-1-yl)butan-1-amine Show/Hide	C31H33F7N2	1
1	IC50 = 1070 nM Bioactivity Info	TI LI LO TS
CP0464518 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-5-(4-phenylpiperidin-1-yl)pentanamide Show/Hide	C31H31F7N2O	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0501957 Compound Info	(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(piperidin-1-yl)butanamide Show/Hide	C24H25F7N2O	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0563074 Compound Info	US8906911, 23 Show/Hide	C28H38F3N3O3	1
1	IC50 = 1110 nM Bioactivity Info	TI LI LO TS
CP0565601 Compound Info	US8906911, 17 Show/Hide	C27H35F4N3O3	1
1	IC50 = 1290 nM Bioactivity Info	TI LI LO TS
CP0563855 Compound Info	US8906911, 24 Show/Hide	C28H38F3N3O3	1
1	IC50 = 1390 nM Bioactivity Info	TI LI LO TS
CP0466641 Compound Info	US8906911, 55 Show/Hide	C29H37F6N3O3	1
1	IC50 = 1410 nM Bioactivity Info	TI LI LO TS
CP0555433 Compound Info	US8906911, 11 Show/Hide	C27H37F3N4O3	1
1	IC50 = 1470 nM Bioactivity Info	TI LI LO TS
CP0464561 Compound Info	N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(dimethylamino)ethylamino]-2-phenylacetamide Show/Hide	C21H23F6N3O	1
1	IC50 = 1477 nM Bioactivity Info	TI LI LO TS
CP0551302 Compound Info	(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)pentan-1-amine Show/Hide	C31H33F7N2	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0466640 Compound Info	US8906911, 43 Show/Hide	C28H35F6N3O3	1
1	IC50 = 1520 nM Bioactivity Info	TI LI LO TS
CP0419276 Compound Info	US8906911, 10 Show/Hide	C32H37F3N4O3	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0468211 Compound Info	US8906911, 37 Show/Hide	C28H35F3N4O3	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0468212 Compound Info	US8906911, 38 Show/Hide	C27H37F3N4O3	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0468213 Compound Info	US8906911, 44 Show/Hide	C27H35ClN4O3	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0565603 Compound Info	US8906911, 45 Show/Hide	C28H35F3N4O3	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0555431 Compound Info	US8906911, 3 Show/Hide	C26H35F3N4O3	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0428167 Compound Info	US8906911, 34 Show/Hide	C26H35F3N4O3	1
1	IC50 = 2780 nM Bioactivity Info	TI LI LO TS
CP0516782 Compound Info	US8906911, 54 Show/Hide	C29H37F3N4O3	1
1	IC50 = 2780 nM Bioactivity Info	TI LI LO TS
CP0556910 Compound Info	US8906911, 58 Show/Hide	C28H37ClN4O3	1
1	IC50 = 2780 nM Bioactivity Info	TI LI LO TS
CP0563856 Compound Info	US8906911, 35 Show/Hide	C25H35ClN4O3	1
1	IC50 = 2780 nM Bioactivity Info	TI LI LO TS
CP0649585 Compound Info	1-butyl-3-(2-methylpropyl)-9-(6-phenylhexyl)-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H46ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0662025 Compound Info	(3R)-3-cyclohexylmethyl-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C30H48ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0878092 Compound Info	(3S)-3-(2-methylpropyl)-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C27H44ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0651200 Compound Info	9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C25H38ClN3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0657856 Compound Info	(+/-)-1-butyl-3-(cyclohexylmethyl)-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride Show/Hide	C32H44ClN3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0662064 Compound Info	9-(1,4-benzodioxane-6-yl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H42ClN3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0662079 Compound Info	(3S)-3-cyclohexylmethyl-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C30H48ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0720738 Compound Info	(+/-)-1-butyl-3-isobutyl-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride Show/Hide	C29H40ClN3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0837909 Compound Info	9-(4-allyloxyphenylmethyl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C29H44ClN3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0878091 Compound Info	(3R)-3-(2-methylpropyl)-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C27H44ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0449524 Compound Info	4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-N-methyl-N-(2-(piperidin-1-yl)ethyl)benzenamine Show/Hide	C21H24Cl2N4	1
1	IC50 = 13400 nM Bioactivity Info	TI LI LO TS
CP0419274 Compound Info	US8906911, 8 Show/Hide	C27H37F3N4O3	1
1	IC50 = 14430 nM Bioactivity Info	TI LI LO TS
CP0400726 Compound Info	US8906911, 41 Show/Hide	C27H37F3N4O3	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0428166 Compound Info	US8906911, 33 Show/Hide	C26H35F3N4O3	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0515438 Compound Info	US8906911, 4 Show/Hide	C26H35F3N4O3	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0466642 Compound Info	US8906911, Compound B Show/Hide	C25H34F3N3O2	1
1	IC50 = 28000 nM Bioactivity Info	TI LI LO TS
CP0651215 Compound Info	9-benzyl-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride Show/Hide	C23H36ClN3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0856132 Compound Info	(3S)-1,9-dibenzyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride Show/Hide	C26H34ClN3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0651202 Compound Info	1-butyl-3-cyclohexylmethyl-9-(4-methoxyphenylmethyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C27H42ClN3O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0699196 Compound Info	3-(2-methylpropyl)-9-(4-phenoxyphenylmethyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H38ClN3O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0850182 Compound Info	(3R)-1,9-dibenzyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride Show/Hide	C26H34ClN3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0462820 Compound Info	US8906911, Compound A Show/Hide	C26H36F3N3O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0129722 Compound Info	2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid Show/Hide	C18H11Cl3N2O5S	1
1	Ki = 1.259 nM Bioactivity Info	TI LI LO TS
CP0497113 Compound Info	3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid Show/Hide	C18H11Cl3N2O5S	1
1	Ki = 1.585 nM Bioactivity Info	TI LI LO TS
CP0502322 Compound Info	2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-6-fluorobenzoic acid Show/Hide	C18H10Cl3FN2O5S	1
1	Ki = 1.995 nM Bioactivity Info	TI LI LO TS
CP0496030 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C26H24Cl2F3N3O4S	1
1	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0221913 Compound Info	4-[5-chloro-3-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C26H25Cl2F3N4O4S	1
1	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0116928 Compound Info	2-[4-chloro-2-[(3,4-dichlorophenyl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C19H12Cl3NO5S	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS
CP0427754 Compound Info	4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid Show/Hide	C18H11Cl3N2O5S	1
1	Ki = 3.162 nM Bioactivity Info	TI LI LO TS
CP0391753 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methoxyphenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C27H26Cl2F3N3O5S	1
1	Ki = 4 nM Bioactivity Info	TI LI LO TS
CP0502323 Compound Info	2-[4-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C17H11Cl2NO5S2	1
1	Ki = 5.012 nM Bioactivity Info	TI LI LO TS
CP0094565 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methoxy-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C27H26Cl2F3N3O5S	1
1	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0430764 Compound Info	2-[4-chloro-2-[(3-chlorophenyl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C19H13Cl2NO5S	1
1	Ki = 7.943 nM Bioactivity Info	TI LI LO TS
CP0401059 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methyl-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C27H26Cl2F3N3O4S	1
1	Ki = 8 nM Bioactivity Info	TI LI LO TS
CP0461434 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methylphenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C27H26Cl2F3N3O4S	1
1	Ki = 8 nM Bioactivity Info	TI LI LO TS
CP0039269 Compound Info	3,4-dichloro-N-[5-chloro-2-(2-methylpyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide Show/Hide	C17H12Cl3N3O3S	2
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
2	Ki = 1259 nM Bioactivity Info	TI LI LO TS
CP0373790 Compound Info	5-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxypyridine-3-carboxylic acid Show/Hide	C17H10Cl3N3O5S	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0461432 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methoxyphenoxy]-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C28H28Cl2F3N3O5S	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0517819 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C27H26Cl2F3N3O4S	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0228770 Compound Info	3,4-dichloro-N-[5-chloro-2-(5-chloropyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide Show/Hide	C16H9Cl4N3O3S	1
1	Ki = 12.59 nM Bioactivity Info	TI LI LO TS
CP0273839 Compound Info	4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C25H25Cl3N4O4S	2
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 20 nM Bioactivity Info	TI LI LO TS
CP0298012 Compound Info	4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C24H23Cl3N4O4S	2
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 63 nM Bioactivity Info	TI LI LO TS
CP0401900 Compound Info	3,4-dichloro-N-[5-chloro-2-(6-cyanopyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide Show/Hide	C17H9Cl3N4O3S	1
1	Ki = 15.85 nM Bioactivity Info	TI LI LO TS
CP0390963 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methylphenoxy]-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C28H28Cl2F3N3O4S	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0226249 Compound Info	3,4-dichloro-N-(5-chloro-2-pyridin-3-yloxypyridin-3-yl)benzenesulfonamide Show/Hide	C16H10Cl3N3O3S	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0387732 Compound Info	2-[4-chloro-2-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C19H13Cl2NO5S	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0400865 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methyl-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C28H28Cl2F3N3O4S	1
1	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0400866 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methoxy-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C28H28Cl2F3N3O5S	1
1	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0125371 Compound Info	2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-hydroxyethyl)benzamide Show/Hide	C20H16Cl3N3O5S	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0863194 Compound Info	3-p-Tolyl-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid (4-{[methyl-(tetrahydro-pyran-4-yl)-amino]-methyl}-phenyl)-amide Show/Hide	C32H36N2O2	1
1	Ki = 28.84 nM Bioactivity Info	TI LI LO TS
CP0390615 Compound Info	1-(3,4-dichlorobenzyl)-5-hydroxy-1H-indole-2-carboxylic acid Show/Hide	C16H11Cl2NO3	1
1	Ki = 29 nM Bioactivity Info	TI LI LO TS
CP0416381 Compound Info	2-[3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid Show/Hide	C18H12Cl2N2O5S	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0506133 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-6-fluoro-4-(trifluoromethyl)phenoxy]benzoic acid Show/Hide	C20H12ClF4NO5S	1
1	Ki = 31.62 nM Bioactivity Info	TI LI LO TS
CP0430766 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-4-fluorophenoxy]benzoic acid Show/Hide	C19H13ClFNO5S	1
1	Ki = 39.81 nM Bioactivity Info	TI LI LO TS
CP0275299 Compound Info	4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperazin-1-ylethyl)benzamide Show/Hide	C24H24Cl3N5O4S	2
1	Ki = 40 nM Bioactivity Info	TI LI LO TS
2	Ki = 251 nM Bioactivity Info	TI LI LO TS
CP0104462 Compound Info	(E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide Show/Hide	C27H31Cl2N3O2	2
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
2	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0471020 Compound Info	2-[4-[(3,4-dichlorophenyl)sulfonylamino]pyridin-3-yl]oxybenzoic acid Show/Hide	C18H12Cl2N2O5S	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0488745 Compound Info	3,4-dichloro-N-[5-cyano-2-(2-methylpyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide Show/Hide	C18H12Cl2N4O3S	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0387506 Compound Info	4-[4-chloro-2-[(3,4-dichlorophenyl)sulfonylamino]phenoxy]-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C26H26Cl3N3O4S	1
1	Ki = 63 nM Bioactivity Info	TI LI LO TS
CP0390739 Compound Info	4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]benzamide Show/Hide	C26H22Cl2F5N3O4S	1
1	Ki = 63 nM Bioactivity Info	TI LI LO TS
CP0516419 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-4-cyanophenoxy]benzoic acid Show/Hide	C20H13ClN2O5S	1
1	Ki = 63.1 nM Bioactivity Info	TI LI LO TS
CP0323451 Compound Info	3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C25H25Cl3N4O4S	2
1	Ki = 79 nM Bioactivity Info	TI LI LO TS
2	Ki = 1259 nM Bioactivity Info	TI LI LO TS
CP0314740 Compound Info	3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C24H23Cl3N4O4S	2
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
2	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0387734 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]-6-fluorobenzoic acid Show/Hide	C20H12ClF4NO5S	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0473576 Compound Info	2-[2-(benzenesulfonamido)-4-chlorophenoxy]benzoic acid Show/Hide	C19H14ClNO5S	1
1	Ki = 158.49 nM Bioactivity Info	TI LI LO TS
CP0493533 Compound Info	3,4-dichloro-N-(5-chloro-2-pyridazin-3-yloxypyridin-3-yl)benzenesulfonamide Show/Hide	C15H9Cl3N4O3S	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0209406 Compound Info	3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperazin-1-ylethyl)benzamide Show/Hide	C24H24Cl3N5O4S	2
1	Ki = 200 nM Bioactivity Info	TI LI LO TS
2	Ki = 2511 nM Bioactivity Info	TI LI LO TS
CP0250469 Compound Info	6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[1,4-dihydro-2H-benzo[d][1,3]oxazine-4,4'-(hexahydropyridine)]-2-one Show/Hide	C25H27N3O3	1
1	Ki = 208.93 nM Bioactivity Info	TI LI LO TS
CP0416380 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C19H14ClNO5S	1
1	Ki = 251.19 nM Bioactivity Info	TI LI LO TS
CP0185499 Compound Info	(R)-N-(2-(1-(2,4-dimethylbenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide Show/Hide	C23H26F3N3O2	1
1	Ki = 288.4 nM Bioactivity Info	TI LI LO TS
CP0416382 Compound Info	2-[4-chloro-2-(methanesulfonamido)phenoxy]benzoic acid Show/Hide	C14H12ClNO5S	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0438745 Compound Info	2-[2-chloro-6-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid Show/Hide	C19H13Cl2NO5S	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0499946 Compound Info	2-[5-[(3,4-dichlorophenyl)sulfonylamino]pyrimidin-4-yl]oxybenzoic acid Show/Hide	C17H11Cl2N3O5S	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0464608 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-5-methylphenoxy]benzoic acid Show/Hide	C20H16ClNO5S	1
1	Ki = 630.96 nM Bioactivity Info	TI LI LO TS
CP0209407 Compound Info	2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide Show/Hide	C24H23Cl3N4O4S	2
1	Ki = 631 nM Bioactivity Info	TI LI LO TS
2	Ki = 2512 nM Bioactivity Info	TI LI LO TS
CP0298013 Compound Info	2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide Show/Hide	C25H25Cl3N4O4S	2
1	Ki = 794 nM Bioactivity Info	TI LI LO TS
2	Ki = 1585 nM Bioactivity Info	TI LI LO TS
CP0502324 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]benzoic acid Show/Hide	C20H13ClF3NO5S	1
1	Ki = 794.33 nM Bioactivity Info	TI LI LO TS
CP0514942 Compound Info	2-[3-[(3,4-dichlorophenyl)sulfonylamino]pyrazin-2-yl]oxybenzoic acid Show/Hide	C17H11Cl2N3O5S	1
1	Ki = 794.33 nM Bioactivity Info	TI LI LO TS
CP0471061 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-4-methylsulfonylphenoxy]benzoic acid Show/Hide	C20H16ClNO7S2	1
1	Ki > 3162.28 nM Bioactivity Info	TI LI LO TS
CP0516417 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-3-fluorophenoxy]benzoic acid Show/Hide	C19H13ClFNO5S	1
1	Ki > 3162.28 nM Bioactivity Info	TI LI LO TS
CP0516418 Compound Info	2-[2-[(4-chlorophenyl)sulfonylamino]-6-methylphenoxy]benzoic acid Show/Hide	C20H16ClNO5S	1
1	Ki > 3162.28 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000064 , Chem-1

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Cell Line ID: CL000100 , U-937

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0066063 Compound Info	N-[2-[[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C27H34F3N3O4S	2
1	IC50 = 0.8 nM
2	IC50 = 1.3 nM
CP0059668 Compound Info	N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide Show/Hide	C29H36F3N3O4S	1
1	IC50 = 1 nM
CP0154997 Compound Info	N-[(1R,2S,5R)-5-[methyl(propan-2-yl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide Show/Hide	C25H33F3N6O2	1
1	IC50 = 1.1 nM
CP0099584 Compound Info	N-[2-[[2-[[(1S,3S,4R)-4-amino-3-(benzenesulfonylmethyl)cyclohexyl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide Show/Hide	C27H32F3N5O5S	1
1	IC50 = 1.4 nM
CP0315991 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-ethyl tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 1.5 nM
CP0522786 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-propyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C26H36F6N2O2	1
1	IC50 = 2.999 nM
CP0035313 Compound Info	(S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetic acid Show/Hide	C29H30F3N3O3	1
1	IC50 = 4 nM
CP0514673 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-3-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2O2	1
1	IC50 = 4.603 nM
CP0204218 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxy-3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C24H29F9N2O3	1
1	IC50 = 5.495 nM
CP0053417 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H29F9N2O2	1
1	IC50 = 5.998 nM
CP0126803 Compound Info	2-(3-isopropylureido)-N-(2-((1S,2R)-2-(4-(methylthio)benzamido)cyclohexylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide Show/Hide	C28H34F3N5O4S	1
1	IC50 = 7.5 nM
CP0388120 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-cyclopropyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C26H34F6N2O2	1
1	IC50 = 7.798 nM
CP0051245 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-5-(trifluoromethyl)benzamide Show/Hide	C26H34F3N5O3	1
1	IC50 = 11 nM
CP0202246 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-(ethylamino)-5-(trifluoromethyl)benzamide Show/Hide	C28H38F3N5O3	1
1	IC50 = 13 nM
CP0185497 Compound Info	(S)-1-(2-((2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)carbamoyl)-4-(trifluoromethyl)phenyl)-3-isopropylurea Show/Hide	C30H41F3N6O4	1
1	IC50 = 15 nM
CP0185499 Compound Info	(R)-N-(2-(1-(2,4-dimethylbenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide Show/Hide	C23H26F3N3O2	1
1	IC50 = 17 nM
CP0136162 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(ethylamino)-5-(trifluoromethyl)benzamide Show/Hide	C28H38F3N5O3	1
1	IC50 = 19 nM
CP0528311 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-(benzylamino)-5-(trifluoromethyl)benzamide Show/Hide	C33H40F3N5O3	1
1	IC50 = 19 nM
CP0160834 Compound Info	(S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide Show/Hide	C25H31BrF3N5O3	1
1	IC50 = 20 nM
CP0315992 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrothiophen-3-ylamino)cyclopentanecarboxamide Show/Hide	C22H28F6N2OS	1
1	IC50 = 21.98 nM
CP0199851 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-amino-5-(trifluoromethyl)benzamide Show/Hide	C26H34F3N5O3	1
1	IC50 = 23 nM
CP0144619 Compound Info	[(2R,3aR,6aR)-2-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone Show/Hide	C24H32F3N3O3	2
1	IC50 = 24 nM
2	IC50 = 61 nM
CP0666580 Compound Info	Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium chloride(TAK-779) Show/Hide	C33H39ClN2O2	1
1	IC50 = 27 nM
CP0493802 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,3-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 27.99 nM
CP0302119 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(oxepan-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 29.99 nM
CP0085708 Compound Info	(E)-1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylprop-2-en-1-one Show/Hide	C32H37F3N4O4	1
1	IC50 = 30 nM
CP0085738 Compound Info	2-(oxan-4-yl)ethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C31H43F3N4O6	1
1	IC50 = 31 nM
CP0219341 Compound Info	oxan-4-ylmethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C30H41F3N4O6	1
1	IC50 = 32 nM
CP0134117 Compound Info	2-pyrrolidin-1-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C30H42F3N5O5	1
1	IC50 = 33 nM
CP0069631 Compound Info	2-methylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C28H39F3N4O5	1
1	IC50 = 35 nM
CP0238399 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-thiopyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2OS	1
1	IC50 = 35.97 nM
CP0208642 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide Show/Hide	C22H26F3N5O3	1
1	IC50 = 37 nM
CP0326435 Compound Info	(3aR,5R,6aR)-N'-cyano-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboximidamide Show/Hide	C25H32F3N7O3	1
1	IC50 = 37 nM
CP0258415 Compound Info	2-morpholin-4-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C30H42F3N5O6	1
1	IC50 = 41 nM
CP0134118 Compound Info	2-acetamidoethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C28H38F3N5O6	1
1	IC50 = 45 nM
CP0201872 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide Show/Hide	C26H33F3N4O3	1
1	IC50 = 48 nM
CP0165577 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C23H30F6N2O2	1
1	IC50 = 55.98 nM
CP0069637 Compound Info	(3aR,5R,6aR)-N-benzyl-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide Show/Hide	C31H38F3N5O4	1
1	IC50 = 57 nM
CP0155510 Compound Info	2,2-dimethylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C29H41F3N4O5	1
1	IC50 = 59 nM
CP0176443 Compound Info	[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-phenyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone Show/Hide	C29H35F3N4O3	1
1	IC50 = 62 nM
CP0165578 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclohexylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C24H32F6N2O	1
1	IC50 = 63.97 nM
CP0069632 Compound Info	(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide Show/Hide	C24H32F3N5O4	1
1	IC50 = 64 nM
CP0215141 Compound Info	(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide Show/Hide	C22H25F3N4O3	1
1	IC50 = 66 nM
CP0085707 Compound Info	(E)-1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-4,4-dimethylpent-2-en-1-one Show/Hide	C30H41F3N4O4	1
1	IC50 = 68 nM
CP0331716 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C27H30F6N2O	1
1	IC50 = 76.91 nM
CP0176444 Compound Info	(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-methyl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide Show/Hide	C25H34F3N5O4	1
1	IC50 = 77 nM
CP0167981 Compound Info	N-[2-[[(1S,3S,4R)-3-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C27H34F3N3O4S	1
1	IC50 = 79 nM
CP0317447 Compound Info	2-methoxyethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C27H37F3N4O6	1
1	IC50 = 82 nM
CP0315993 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrofuran-3-ylamino)cyclopentanecarboxamide Show/Hide	C22H28F6N2O2	1
1	IC50 = 84.92 nM
CP0202906 Compound Info	1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-cyclopropylprop-2-yn-1-one Show/Hide	C29H35F3N4O4	1
1	IC50 = 87 nM
CP0176445 Compound Info	1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylpropan-1-one Show/Hide	C32H39F3N4O4	1
1	IC50 = 110 nM
CP0339382 Compound Info	benzyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C31H37F3N4O5	1
1	IC50 = 118 nM
CP0165576 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxytetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C23H30F6N2O3	1
1	IC50 = 123.03 nM
CP0340173 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclopentylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C23H30F6N2O	1
1	IC50 = 155.96 nM
CP0481537 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cycloheptylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O	1
1	IC50 = 174.98 nM
CP0277402 Compound Info	(R)-N-(2-(1-(4-chlorobenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide Show/Hide	C21H21ClF3N3O2	1
1	IC50 = 180 nM
CP0459575 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(1,2,3,4-tetrahydronaphthalen-2-ylamino)cyclopentanecarboxamide Show/Hide	C28H32F6N2O	1
1	IC50 = 187.07 nM
CP0282451 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclobutylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C22H28F6N2O	1
1	IC50 = 193.2 nM
CP0053416 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,5-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C25H34F6N2O2	1
1	IC50 = 230.14 nM
CP0155511 Compound Info	[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone Show/Hide	C24H33F3N4O3	1
1	IC50 = 300 nM
CP0119832 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-((tetrahydro-2H-pyran-4-yl)methylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 362.24 nM
CP0346051 Compound Info	1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]ethanone Show/Hide	C25H33F3N4O4	1
1	IC50 = 395 nM
CP0258416 Compound Info	methyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C25H33F3N4O5	1
1	IC50 = 410 nM
CP0347344 Compound Info	(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-propan-2-yl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide Show/Hide	C27H38F3N5O4	1
1	IC50 = 410 nM
CP0262145 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(chroman-4-ylamino)-1-isopropylcyclopentanecarboxamide Show/Hide	C27H30F6N2O2	1
1	IC50 = 418.79 nM
CP0154057 Compound Info	phenyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate Show/Hide	C30H35F3N4O5	1
1	IC50 = 560 nM
CP0133098 Compound Info	N-[2-[[(2R)-1-[(4-chlorophenyl)methyl]pyrrolidin-2-yl]methylamino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C22H23ClF3N3O2	1
1	IC50 = 570 nM
CP0388118 Compound Info	(1S,3R)-3-(1,1-Dioxo-hexahydro-1lambda6-thiopyran-4-ylamino)-1-isopropyl-cyclopentanecarboxylic acid 3,5-bis-trifluoromethyl-benzylamide Show/Hide	C23H30F6N2O3S	1
1	IC50 = 630.96 nM
CP0330247 Compound Info	N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C22H23ClF3N3O2	1
1	IC50 = 660 nM
CP0133099 Compound Info	N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methylamino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C23H25ClF3N3O2	1
1	IC50 = 700 nM
CP0277285 Compound Info	3-{1-Hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-propyl}-phenol Show/Hide	C28H34N2O4S	1
1	IC50 = 710 nM
CP0467606 Compound Info	(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(2-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide Show/Hide	C24H32F6N2O2	1
1	IC50 = 765.6 nM
CP0069634 Compound Info	[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone Show/Hide	C23H31F3N4O3	1
1	IC50 = 780 nM
CP0298935 Compound Info	N-[2-[[(3S)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Show/Hide	C21H21ClF3N3O2	1
1	IC50 = 1200 nM
CP0717334 Compound Info	N-({[1-(4-Chloro-benzyl)-pyrrolidin-2-ylmethyl]-carbamoyl}-methyl)-3-trifluoromethyl-benzamide Show/Hide	C22H23ClF3N3O2	1
1	IC50 = 3100 nM
CP0254041 Compound Info	4-Methyl-thiophene-2-carboxylic acid N''-{2-[4-(4-chloro-benzyl)-[1,4]diazepan-1-yl]-acetyl}-hydrazide Show/Hide	C20H25ClN4O2S	1
1	IC50 = 7400 nM
CP0649585 Compound Info	1-butyl-3-(2-methylpropyl)-9-(6-phenylhexyl)-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H46ClN3O2	1
1	IC50 > 10000 nM
CP0651200 Compound Info	9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C25H38ClN3O4	1
1	IC50 > 10000 nM
CP0657856 Compound Info	(+/-)-1-butyl-3-(cyclohexylmethyl)-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride Show/Hide	C32H44ClN3O3	1
1	IC50 > 10000 nM
CP0662064 Compound Info	9-(1,4-benzodioxane-6-yl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H42ClN3O4	1
1	IC50 > 10000 nM
CP0720738 Compound Info	(+/-)-1-butyl-3-isobutyl-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride Show/Hide	C29H40ClN3O3	1
1	IC50 > 10000 nM
CP0837909 Compound Info	9-(4-allyloxyphenylmethyl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C29H44ClN3O3	1
1	IC50 > 10000 nM
CP0651202 Compound Info	1-butyl-3-cyclohexylmethyl-9-(4-methoxyphenylmethyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C27H42ClN3O3	1
1	IC50 > 30000 nM
CP0699196 Compound Info	3-(2-methylpropyl)-9-(4-phenoxyphenylmethyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride Show/Hide	C28H38ClN3O3	1
1	IC50 > 30000 nM
CP0149803 Compound Info	3,4-dichloro-N-[5-chloro-2-(triazol-1-ylmethyl)phenyl]benzenesulfonamide Show/Hide	C15H11Cl3N4O2S	1
1	Ki = 10 nM
CP0045327 Compound Info	(E)-3-(3,4-Dichloro-phenyl)-N-{4-[(R)-3-((2S,7aS)-5-hydroxy-1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-8-ylmethyl]-cyclohexyl}-acrylamide Show/Hide	C31H35Cl2N3O2	1
1	Ki = 40 nM
CP0104462 Compound Info	(E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide Show/Hide	C27H31Cl2N3O2	1
1	Ki = 50 nM

Clinical Information about the Protein

Target 1 ( C-C chemokine receptor type 2 (CCR2) )

Target Type	Clinical trial Target
Disease	7 Target-related Diseases				7
1	Diabetic nephropathy [ICD-11: GB61.Z]
2	Human immunodeficiency virus infection [ICD-11: 1C62]
3	Multiple sclerosis [ICD-11: 8A40]
4	Diabetic retinopathy [ICD-11: 9B71.0]
5	Chronic obstructive pulmonary disease [ICD-11: CA22]
6	Arteriosclerosis [ICD-11: BD40]
7	Inflammation [ICD-11: 1A00-CA43.1]
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	BMS-813160	Drug Info	Phase 2	Diabetic nephropathy
2	CCX-140	Drug Info	Phase 2	Diabetic nephropathy
3	Cenicriviroc	Drug Info	Phase 2	Human immunodeficiency virus infection
4	MK-0812	Drug Info	Phase 2	Multiple sclerosis
5	Aminoguanidine	Drug Info	Phase 1	Diabetic retinopathy
Discontinued Drug(s)	3 Discontinued Drugs				3
1	CCX915	Drug Info	Discontinued in Phase 1	Multiple sclerosis
2	INCB3344	Drug Info	Terminated	Arteriosclerosis
3	SB-282241	Drug Info	Terminated	Inflammation
Investigative Drug(s)	1 Investigative Drug				1
1	BMS-A	Drug Info	Investigative	Inflammation
Preclinical Drug(s)	1 Preclinical Drug				1
1	RS-504393	Drug Info	Preclinical	Chronic obstructive pulmonary disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT04128	C-C chemokine receptor type 2	Mus musculus, Mouse	Protein Info
PT04757	C-C chemokine receptor type 2	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han