| Compound ID |
Compound Name |
Compound Formula |
|
CP0277402
|
(R)-N-(2-(1-(4-chlorobenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
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|
C21H21ClF3N3O2
|
4
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
| 3 |
IC50 = 180 nM
|
|
|
| 4 |
IC50 > 300 nM
|
|
|
|
CP0133099
|
N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methylamino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C23H25ClF3N3O2
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0298935
|
N-[2-[[(3S)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C21H21ClF3N3O2
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0330247
|
N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H23ClF3N3O2
|
1
|
| 1 |
EC50 = 610 nM
|
|
|
|
CP0717334
|
N-({[1-(4-Chloro-benzyl)-pyrrolidin-2-ylmethyl]-carbamoyl}-methyl)-3-trifluoromethyl-benzamide
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|
C22H23ClF3N3O2
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0133098
|
N-[2-[[(2R)-1-[(4-chlorophenyl)methyl]pyrrolidin-2-yl]methylamino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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|
C22H23ClF3N3O2
|
1
|
| 1 |
EC50 = 810 nM
|
|
|
|
CP0849309
|
2,2-dimethyl-N-[(3S)-2-oxoazepan-3-yl]propanamide
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|
C11H20N2O2
|
1
|
| 1 |
ED50 = 0.04 nM
|
|
|
|
CP0845544
|
(S)-3-(2',2'-Dimethyl-butyryl)amino-caprolactam
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|
C12H22N2O2
|
1
|
| 1 |
ED50 = 0.07 nM
|
|
|
|
CP0917226
|
(S)-3-(2',2',5'-Trimethyl-hexanoyl)amino-caprolactam
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|
C15H28N2O2
|
1
|
| 1 |
ED50 = 0.08 nM
|
|
|
|
CP0845543
|
(S)-3-(1'-Methylcyclohexanecarbonyl)amino-caprolactam
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|
C14H24N2O2
|
1
|
| 1 |
ED50 = 0.09 nM
|
|
|
|
CP0845545
|
(S)-3-(2',2'-Dimethyl-dodecanoyl)amino-caprolactam
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|
C20H38N2O2
|
1
|
| 1 |
ED50 = 0.09 nM
|
|
|
|
CP0845547
|
(S)-3-(1'-Adamantanecarbonyl)amino-caprolactam
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|
C17H26N2O2
|
1
|
| 1 |
ED50 = 0.09 nM
|
|
|
|
CP0889561
|
(S)-3-(2',2',5'-Trimethyl-hex-4'-enoyl)amino-caprolactam
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|
C15H26N2O2
|
1
|
| 1 |
ED50 = 0.2 nM
|
|
|
|
CP0845541
|
(R)-3-(1'-Adamantanecarbonyl)amino-caprolactam
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|
C17H26N2O2
|
1
|
| 1 |
ED50 = 0.44 nM
|
|
|
|
CP0858994
|
MMV1765344
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|
C13H22N2O2
|
1
|
| 1 |
ED50 = 0.5 nM
|
|
|
|
CP0917199
|
(S)-3-(2',2'-Dimethyl-pentanoyl)amino-caprolactam
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|
C13H24N2O2
|
1
|
| 1 |
ED50 = 0.5 nM
|
|
|
|
CP0845542
|
(S)-3-(1'-Adamantanylmethanecarbonyl)amino-caprolactam
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|
C18H28N2O2
|
1
|
| 1 |
ED50 = 0.8 nM
|
|
|
|
CP0849308
|
(S)-3-(Cyclohex-1'-enecarbonyl)amino-caprolactam
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|
C13H20N2O2
|
1
|
| 1 |
ED50 = 0.8 nM
|
|
|
|
CP0849306
|
(S)-3-(2',2'-Dimethyl-pent-4-enoyl)amino-caprolactam
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|
C13H22N2O2
|
1
|
| 1 |
ED50 = 1 nM
|
|
|
|
CP0908505
|
(S)-3-(3',3'-Dimethyldodecanoyl)amino-caprolactam
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|
C20H38N2O2
|
1
|
| 1 |
ED50 = 4 nM
|
|
|
|
CP0845546
|
(R)-3-(2',2'-Dimethyl-dodecanoyl)amino-caprolactam
Show/Hide
|
C20H38N2O2
|
1
|
| 1 |
ED50 = 4.5 nM
|
|
|
|
CP0917200
|
(S)-3-(trans-4'-Pentylcyclohexane-1'-carbonyl)amino-caprolactam
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|
C18H32N2O2
|
1
|
| 1 |
ED50 = 5 nM
|
|
|
|
CP0849307
|
(S)-3-(4'-Pentyl[2,2,2]bicyclo-octane-1'-carbonyl)amino-caprolactam
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|
C20H34N2O2
|
1
|
| 1 |
ED50 = 7 nM
|
|
|
|
CP0915984
|
(S)-(3'-Chloro-2'-(chloromethyl)-2'-methylpropionyl)amino-caprolactam
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|
C11H18Cl2N2O2
|
1
|
| 1 |
ED50 = 9 nM
|
|
|
|
CP0917201
|
(S)-(E)-3-(2'-Methyldodec-2'-enoyl)amino-caprolactam
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|
C19H34N2O2
|
1
|
| 1 |
ED50 = 10 nM
|
|
|
|
CP0919855
|
Undecanoic acid (2-oxo-azepan-3-yl)-amide
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|
C18H34N2O2
|
1
|
| 1 |
ED50 = 15 nM
|
|
|
|
CP0921301
|
4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H26ClF3N6O2S
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0379861
|
3-[1-[(3aS,5S,6aR)-3a-[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazine-3-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl]piperidin-4-yl]-N-methylbenzamide
Show/Hide
|
C30H34F3N3O4
|
1
|
| 1 |
IC50 = 0.25 nM
|
|
|
|
CP0271959
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[ethyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C30H38F3N3O4S
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0555763
|
N-[(3S)-1-[(1S,2R,4R)-2-acetamido-4-(tert-butylamino)cyclohexyl]-2-oxopyrrolidin-3-yl]-6-tert-butylpyridine-2-carboxamide
Show/Hide
|
C26H41N5O3
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0151062
|
N-[(3S)-1-[(1S,2R,4R)-2-[(4-methylphenyl)sulfonylmethyl]-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C30H38F3N3O4S
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0904243
|
N-(5-Bromo-4-methyl-1,3-thiazol-2-yl)-4-[(2R)-4-tert-butylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C18H29BrN6O2S
|
1
|
| 1 |
IC50 < 0.45 nM
|
|
|
|
CP0930277
|
4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-(5-chloro-4-cyclopropyl-thiazol-2-yl)piperazine-1-carboxamide
Show/Hide
|
C20H31ClN6O2S
|
1
|
| 1 |
IC50 < 0.45 nM
|
|
|
|
CP0553128
|
N-[(1R,2S,5R)-5-(tert-butylamino)-2-[(3S)-3-[(6-tert-butylpyrido[3,2-d]pyrimidin-4-yl)amino]-2-oxopyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C27H41N7O2
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0957935
|
4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(5-chloro-4-methyl-1,3-thiazol-2-yl)piperazine-1-carboxamide
Show/Hide
|
C18H29ClN6O2S
|
1
|
| 1 |
IC50 = 0.65 nM
|
|
|
|
CP0154997
|
N-[(1R,2S,5R)-5-[methyl(propan-2-yl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C25H33F3N6O2
|
2
|
| 1 |
IC50 = 0.67 nM
|
|
|
| 2 |
IC50 = 0.7 nM
|
|
|
|
CP0066063
|
N-[2-[[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H34F3N3O4S
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0093142
|
3-fluoro-N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-2-oxopyrrolidin-3-yl)-5-(trifluoromethyl)benzamide
Show/Hide
|
C29H35F4N3O4S
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0176092
|
N-[(1R,2S,5R)-5-(tert-butylamino)-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C25H33F3N6O2
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0525682
|
2-amino-N-[2-[[(3R)-1-[(2,4-dimethylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C23H27F3N4O2
|
3
|
| 1 |
IC50 = 0.83 nM
|
|
|
| 2 |
IC50 = 3.2 nM
|
|
|
| 3 |
IC50 = 7.5 nM
|
|
|
|
CP0404934
|
2-amino-N-[2-[[(3R)-1-[(4-ethylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C23H27F3N4O2
|
3
|
| 1 |
IC50 = 0.89 nM
|
|
|
| 2 |
IC50 = 5.3 nM
|
|
|
| 3 |
IC50 = 11 nM
|
|
|
|
CP0059668
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C29H36F3N3O4S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0871018
|
4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-(4-cyclopropylthiazol-2-yl)piperazine-1-carboxamide
Show/Hide
|
C20H32N6O2S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0923124
|
N-(5-Chloro-4-isopropyl-thiazol-2-yl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C19H31ClN6O2S
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0381343
|
[(3aS,5S,6aR)-5-(4-phenylpiperidin-1-yl)-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C28H32F3N3O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0546105
|
N-[(3S)-1-[(1S,2R,4R)-2-acetamido-4-(methylamino)cyclohexyl]-2-oxopyrrolidin-3-yl]-6-tert-butylpyridine-2-carboxamide
Show/Hide
|
C23H35N5O3
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0893929
|
N-(5-chloro-4-ethyl-thiazol-2-yl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C18H29ClN6O2S
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0176091
|
N-[(1R,2S,5R)-5-(methylamino)-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C22H27F3N6O2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0476364
|
N-[1-[4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C25H29F3N6O2
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0513266
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[7-(trifluoromethyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Show/Hide
|
C24H31F3N2O4
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0930276
|
N-(4-tert-Butyl-5-chloro-thiazol-2-yl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C20H33ClN6O2S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0485898
|
2-amino-N-[2-[[(3R)-1-[(4-bromophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H22BrF3N4O2
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
|
| 2 |
IC50 = 116 nM
|
|
|
|
CP0904244
|
N-(4-tert-Butyl-5-fluoro-thiazol-2-yl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C20H33FN6O2S
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0384585
|
N-[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C26H28F3N5O3
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0555761
|
N-[(1R,2S,5R)-5-amino-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C21H25F3N6O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0404935
|
2-amino-N-[2-[[(3R)-1-[(4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O2
|
2
|
| 1 |
IC50 = 3.1 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0191134
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3,5-bis(trifluoromethyl)benzamide
Show/Hide
|
C30H35F6N3O4S
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0161073
|
N-(3,4-dichlorophenyl)-4-[(2R)-4-propan-2-ylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C19H27Cl2N5O2
|
3
|
| 1 |
IC50 = 3.5 nM
|
|
|
| 2 |
IC50 = 5.1 nM
|
|
|
| 3 |
IC50 = 5.8 nM
|
|
|
|
CP0382123
|
2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H22ClF3N4O2
|
3
|
| 1 |
IC50 = 3.6 nM
|
|
|
| 2 |
IC50 = 23.1 nM
|
|
|
| 3 |
IC50 = 26 nM
|
|
|
|
CP0516054
|
2-amino-N-[2-[[(3R)-1-[(4-ethenylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C23H25F3N4O2
|
2
|
| 1 |
IC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
|
CP0455496
|
N-[1-[4-[3-(dimethylamino)phenyl]cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C28H35F3N6O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 5 nM
|
|
|
|
CP0397629
|
N-[2-[[1-[4-hydroxy-4-(2-propan-2-yloxy-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H31F3N4O4S
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 5 nM
|
|
|
|
CP0499497
|
[(3aS,5S,6aR)-2-ethyl-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C25H34F3N3O4
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0496937
|
2-amino-N-[2-[[(3R)-1-[(3-amino-4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H23ClF3N5O2
|
2
|
| 1 |
IC50 = 4.1 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0555759
|
N-[(1R,2S,5R)-5-(dimethylamino)-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide
Show/Hide
|
C23H29F3N6O2
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0452311
|
N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H28F3N3O4
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0494300
|
2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(2-propan-2-yl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
|
C26H33F3N6OS
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0290750
|
N-(3,4-dichlorophenyl)-4-[[(3R)-1-(2-phenylethyl)piperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C25H32Cl2N4O
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 42 nM
|
|
|
|
CP0131902
|
N-[1-(4-pyridin-3-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C25H27F3N6O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0565897
|
N-[1-(4-pyridin-2-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C25H27F3N6O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0404941
|
2-amino-N-[2-[[(3R)-1-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H23F3N4O3
|
2
|
| 1 |
IC50 = 5.1 nM
|
|
|
| 2 |
IC50 = 42 nM
|
|
|
|
CP0404933
|
2-amino-N-[2-[[(3R)-1-[(3-amino-4-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H26F3N5O3
|
2
|
| 1 |
IC50 = 5.3 nM
|
|
|
| 2 |
IC50 = 8.8 nM
|
|
|
|
CP0427840
|
N-[2-[[(3R)-1-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H22F3N3O3
|
3
|
| 1 |
IC50 = 5.5 nM
|
|
|
| 2 |
IC50 = 226 nM
|
|
|
| 3 |
IC50 = 365 nM
|
|
|
|
CP0458500
|
N-[1-[4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C25H29F3N6O
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0404940
|
2-amino-N-[2-[[(3R)-1-[(3-amino-4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H26F3N5O2
|
2
|
| 1 |
IC50 = 6.1 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0525708
|
N-[2-[[(3R)-1-[(4-ethenylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H24F3N3O2
|
2
|
| 1 |
IC50 = 6.2 nM
|
|
|
| 2 |
IC50 = 121 nM
|
|
|
|
CP0116684
|
[(3aS,5S,6aR)-5-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O4
|
2
|
| 1 |
IC50 = 6.5 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0099584
|
N-[2-[[2-[[(1S,3S,4R)-4-amino-3-(benzenesulfonylmethyl)cyclohexyl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
Show/Hide
|
C27H32F3N5O5S
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0287197
|
N-[2-[[2-[[(1S,3S,4R)-3-(benzenesulfonylmethyl)-4-(propan-2-ylamino)cyclohexyl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
Show/Hide
|
C30H38F3N5O5S
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0403553
|
[(3aS,5S,6aR)-5-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazin-3-yl]methanone
Show/Hide
|
C23H29F3N2O5
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0458353
|
N-[2-[[1-[4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0378265
|
N-[1-[4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C26H31F3N6O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0387679
|
3-[[2-oxo-2-[[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]amino]ethyl]amino]-5-(trifluoromethyl)indazole-1-carboxamide
Show/Hide
|
C23H26F3N7O2S
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 29 nM
|
|
|
|
CP0435918
|
ethyl 4-[3-[[2-[[1-ethyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C24H32F3N5O3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0474702
|
N-[1-[4-(2-ethyl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C25H31F3N6OS
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
|
CP0131899
|
N-[1-[4-(2-hydroxyphenyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H28F3N5O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0340312
|
N-[1-[4-(5-hydroxypyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C25H27F3N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0485202
|
N-[1-[4-(3-methoxypyridin-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H29F3N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0904245
|
4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-(5-chlorothiazol-2-yl)piperazine-1-carboxamide
Show/Hide
|
C17H27ClN6O2S
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
|
CP0051245
|
(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-5-(trifluoromethyl)benzamide
Show/Hide
|
C26H34F3N5O3
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0387677
|
N-[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C27H30F3N5O3
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0193411
|
N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[2-methyl-6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C24H27F3N6O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0054102
|
[(3aS,5S,6aR)-5-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O4
|
2
|
| 1 |
IC50 = 8.7 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0062257
|
(R)-N-(2-(1-(2-(1-(2-chlorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H32ClF3N4O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0168060
|
(R)-N-(2-(1-(2-(4-benzoylpiperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H32F3N5O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0499259
|
N-[1-(4-phenylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C25H28F3N5O
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0452513
|
N-[1-[4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C26H31F3N6O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0485896
|
2-amino-N-[2-[[(3R)-1-[(3-hydroxy-4-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O4
|
2
|
| 1 |
IC50 = 9.2 nM
|
|
|
| 2 |
IC50 = 53 nM
|
|
|
|
CP0966131
|
4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-(5-fluorothiazol-2-yl)piperazine-1-carboxamide
Show/Hide
|
C17H27FN6O2S
|
1
|
| 1 |
IC50 = 9.2 nM
|
|
|
|
CP0427835
|
N-[2-[[(3R)-1-[(4-ethylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H26F3N3O2
|
2
|
| 1 |
IC50 = 9.4 nM
|
|
|
| 2 |
IC50 = 59 nM
|
|
|
|
CP0445411
|
dimethyl-[[4-[[(E)-3-[4-(4-methylphenyl)phenyl]prop-2-enoyl]amino]phenyl]methyl]-(oxan-4-yl)azanium
Show/Hide
|
C30H35N2O2+
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0471425
|
dimethyl-(oxan-4-yl)-[[4-[[(E)-3-[4-[4-(trifluoromethyl)phenyl]phenyl]prop-2-enoyl]amino]phenyl]methyl]azanium
Show/Hide
|
C30H32F3N2O2+
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0095877
|
(R)-N-(2-(1-(2-(4-(2,5-difluorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H30F5N5O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0507629
|
N-[2-[[1-[4-(4-methoxyphenyl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H30F3N3O3
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0455495
|
N-[1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C25H29F3N6O3
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0125750
|
4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
Show/Hide
|
C20H28Cl2N4O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 64 nM
|
|
|
|
CP0156851
|
US9062048, 84
Show/Hide
|
C23H25F3N6O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0404942
|
2-amino-N-[2-[[(3R)-1-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O3
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0378266
|
2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-(4-pyridin-3-ylcyclohexyl)azetidin-3-yl]acetamide
Show/Hide
|
C25H29F3N6O
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 56 nM
|
|
|
|
CP0476366
|
N-[1-[4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C22H25F3N6OS
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0476365
|
2-[4-[4-[3-[[2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]phenyl]acetamide
Show/Hide
|
C27H31F3N6O2
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0400779
|
N-[2-[[2-[[(1S,3S,4R)-3-(benzenesulfonylmethyl)-4-(ethylamino)cyclohexyl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
Show/Hide
|
C29H36F3N5O5S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0404943
|
N-[2-[[(3R)-1-[(4-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O2
|
3
|
| 1 |
IC50 = 12.4 nM
|
|
|
| 2 |
IC50 = 64 nM
|
|
|
| 3 |
IC50 = 116 nM
|
|
|
|
CP0452301
|
N-[2-[[1-[4-(5-hydroxypyridin-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H27F3N4O3
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0387680
|
2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
|
C23H27F3N6OS
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0499076
|
CHEMBL1834640
Show/Hide
|
C23H30F3N5O3
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0476859
|
CHEMBL2204259
Show/Hide
|
C22H25F3N4O3S
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 62 nM
|
|
|
|
CP0382119
|
2-amino-N-[2-[[(3R)-1-[(4-hydroxy-3-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O4
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
|
CP0427831
|
2-amino-N-[2-[[(3R)-1-[(3-amino-4-hydroxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H24F3N5O3
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
|
CP0272021
|
2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
|
C23H27F3N6OS
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0449215
|
ethyl 4-[3-[[2-[[1-carbamoyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C23H29F3N6O4
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 56 nM
|
|
|
|
CP0403499
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-phenyl-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C29H34F3N3O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0452300
|
N-[2-[[1-[4-[3-(dimethylamino)phenyl]-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H33F3N4O3
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0455497
|
ethyl 4-[3-[[2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C22H28F3N5O3
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0239619
|
N-[1-(4-hydroxy-4-phenylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H28F3N5O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0239620
|
N-[1-(4-phenylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H28F3N5O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0185499
|
(R)-N-(2-(1-(2,4-dimethylbenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H26F3N3O2
|
3
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
| 3 |
IC50 = 70 nM
|
|
|
|
CP0125749
|
N-(3,4-dichlorophenyl)-4-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C20H30Cl2N4O
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 58 nM
|
|
|
|
CP0397625
|
N-[2-[[1-[4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H27F3N4O3S
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0443436
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O4
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0492703
|
[(3aS,5S,6aR)-2-cyclopropyl-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C26H34F3N3O4
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
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CP0382613
|
2-amino-6-[(3-chlorophenyl)methyl]-5-cyclopropyl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
Show/Hide
|
C15H14ClN5O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0458181
|
6-[(3-chlorophenyl)methyl]-5-cyclopropyl-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
Show/Hide
|
C15H13ClN4O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0050197
|
N-(3,4-dichlorophenyl)-4-[[(2S)-4-propan-2-ylmorpholin-2-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C19H28Cl2N4O2
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 42 nM
|
|
|
|
CP0169868
|
N-[3-chloro-4-(trifluoromethyl)phenyl]-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C21H28ClF3N4O
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0396532
|
N-[2-[[1-[4-hydroxy-4-[6-[(2-methylpropan-2-yl)oxy]pyridin-3-yl]cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H35F3N4O4
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 49 nM
|
|
|
|
CP0078435
|
N-[1-[4-(3-aminopyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C25H28F3N7O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0385579
|
N-[2-[[1-[4-(6-ethoxypyridin-3-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H31F3N4O4
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0397626
|
N-[2-[[1-[4-hydroxy-4-(5-methyl-1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H27F3N4O3S
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0134118
|
2-acetamidoethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C28H38F3N5O6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0384572
|
3-[[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]amino]-N-tert-butyl-5-(trifluoromethyl)indazole-1-carboxamide
Show/Hide
|
C31H37F3N6O4
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0387674
|
2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-(4-phenylcyclohexyl)azetidin-3-yl]acetamide
Show/Hide
|
C26H30F3N5O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0471085
|
N-[1-[4-(2-methyl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C24H29F3N6OS
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0381314
|
N-[2-[[1-[4-hydroxy-4-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H28F6N4O4
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0254168
|
N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)phthalazin-1-yl]amino]acetamide
Show/Hide
|
C23H25F3N6O2S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0490293
|
N-[1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H29F3N6O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0248587
|
2-[1-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperidin-4-yl]-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]acetamide
Show/Hide
|
C30H35FN4O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0112228
|
[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25Cl2N2O2+
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0458351
|
N-[2-[[1-[4-hydroxy-4-(4-methoxyphenyl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H30F3N3O4
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
|
CP0389887
|
N-[1-[4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1,2-benzoxazol-3-yl]amino]acetamide
Show/Hide
|
C25H28F3N5O3
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0499064
|
N-[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1,2-benzoxazol-3-yl]amino]acetamide
Show/Hide
|
C26H27F3N4O4
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0499075
|
N-[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[1-(2-hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C28H32F3N5O4
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 21 nM
|
|
|
|
CP0511521
|
N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)isoquinolin-1-yl]amino]acetamide
Show/Hide
|
C24H26F3N5O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0957741
|
US8921559, 26
Show/Hide
|
C30H32F3N3O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0555760
|
N-[(1R,2S,5R)-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]-5-(propan-2-ylamino)cyclohexyl]acetamide
Show/Hide
|
C24H31F3N6O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0422360
|
N-[2-[[(3R)-1-[(4-methylsulfanylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O2S
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 204 nM
|
|
|
|
CP0427834
|
N-[2-[[(3R)-1-[(4-bromophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H21BrF3N3O2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 166 nM
|
|
|
|
CP0438300
|
N-[2-[[1-[4-(4-hydroxyphenyl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H28F3N3O3
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 42 nM
|
|
|
|
CP0389104
|
N-[2-[[1-[4-(3H-benzimidazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H28F3N5O2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0290747
|
N-(3,4-dichlorophenyl)-4-[(2R)-4-ethylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C18H25Cl2N5O2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0477529
|
N-[1-[4-(2-cyanophenyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C27H27F3N6O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0069631
|
2-methylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C28H39F3N4O5
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0298024
|
2-[1-[(E)-3-(3,4-difluorophenyl)prop-2-enoyl]piperidin-4-yl]-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]acetamide
Show/Hide
|
C30H34F2N4O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0516055
|
2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-iodobenzamide
Show/Hide
|
C20H22ClIN4O2
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 308 nM
|
|
|
|
CP0466055
|
N-[2-[[1-[4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H28F3N3O5
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0494294
|
2-[[1-(2-hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
|
C24H29F3N6O2S
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 29 nM
|
|
|
|
CP0186872
|
N-[1-[4-hydroxy-4-(1,2-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C23H25F3N6O2S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0208537
|
N-[1-[4-hydroxy-4-(2-propan-2-yl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C26H31F3N6O2S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0062259
|
(R)-N-(2-(1-(2-(1-benzoylpiperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H33F3N4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0095368
|
(R)-N-(2-(1-(2-(4-(2-chlorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H31ClF3N5O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0318895
|
2-[[2-cyano-6-(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
|
C25H25F3N6O2S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0075269
|
2-[1-[(E)-3-(3-fluorophenyl)prop-2-enoyl]piperidin-4-yl]-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]acetamide
Show/Hide
|
C30H35FN4O2
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0438303
|
N-[2-[[1-[4-(2-methoxypyridin-4-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O3
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
|
CP0452299
|
N-[2-[[1-[4-(2,3-dihydro-1-benzofuran-6-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H30F3N3O4
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 52 nM
|
|
|
|
CP0036242
|
2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-(3,4,5-trifluorophenyl)prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C30H33F3N4O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0502864
|
N-(3,4-dichlorophenyl)-4-[[(2S)-4-propan-2-ylpiperazin-2-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C19H29Cl2N5O
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0455498
|
N-[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1,2-benzoxazol-3-yl]amino]acetamide
Show/Hide
|
C22H24F3N5O2S
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0452512
|
N-[1-[4-(ethoxymethyl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C23H32F3N5O2
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 86 nM
|
|
|
|
CP0306780
|
N-(3-chloro-4-methylphenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C21H31ClN4O
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 184 nM
|
|
|
|
CP0521836
|
N-[2-[[1-[4-(6-cyclobutyloxypyridin-3-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H33F3N4O4
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 43 nM
|
|
|
|
CP0331580
|
N-[1-[4-hydroxy-4-(2-methyl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C24H27F3N6O2S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0069632
|
(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Show/Hide
|
C24H32F3N5O4
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0524093
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethoxy)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O5
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0452302
|
N-[2-[[1-[4-(3-methoxypyridin-4-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O3
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0472538
|
ethyl 4-[3-[[2-[[1-prop-2-enyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C25H32F3N5O3
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
IC50 = 53 nM
|
|
|
|
CP0134117
|
2-pyrrolidin-1-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C30H42F3N5O5
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0501593
|
ethyl 4-[3-[[2-[[5-(trifluoromethyl)-1,2-benzoxazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C22H27F3N4O4
|
2
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0326435
|
(3aR,5R,6aR)-N'-cyano-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboximidamide
Show/Hide
|
C25H32F3N7O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0135722
|
[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]thiophen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O3S
|
2
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 109 nM
|
|
|
|
CP0435239
|
cyclohexyl-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]-dimethylazanium
Show/Hide
|
C22H27Cl2N2O+
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0456074
|
N-[1-(4-pyridin-3-ylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C24H27F3N6O
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0057188
|
N-[2-[[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O3S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0435575
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)-methylamino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
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C24H32F3N3O4
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1
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| 1 |
IC50 = 30 nM
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CP0389103
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N-[2-[[1-[4-[2-(dimethylamino)pyrimidin-5-yl]cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H31F3N6O2
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1
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| 1 |
IC50 = 31 nM
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CP0456073
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N-[1-[4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1,2-benzoxazol-3-yl]amino]acetamide
Show/Hide
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C22H24F3N5O2S
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2
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| 1 |
IC50 = 31 nM
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| 2 |
IC50 = 37 nM
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CP0476363
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2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(prop-2-enoxymethyl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
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C24H32F3N5O2
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2
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| 1 |
IC50 = 32 nM
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| 2 |
IC50 = 66 nM
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CP0338507
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4-[(2R)-4-cyclopropylpiperazine-2-carbonyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
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C19H25Cl2N5O2
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2
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| 1 |
IC50 = 32 nM
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| 2 |
IC50 = 38 nM
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CP0085738
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2-(oxan-4-yl)ethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
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C31H43F3N4O6
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1
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| 1 |
IC50 = 32 nM
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CP0085708
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(E)-1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylprop-2-en-1-one
Show/Hide
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C32H37F3N4O4
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1
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| 1 |
IC50 = 33 nM
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CP0499257
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3-[[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]amino]-5-(trifluoromethyl)indazole-1-carboxamide
Show/Hide
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C27H29F3N6O4
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2
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| 1 |
IC50 = 34 nM
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| 2 |
IC50 = 82 nM
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CP0417158
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N-[2-[[2-[[(1S,3S,4R)-3-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
Show/Hide
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C31H40F3N5O5S
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1
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| 1 |
IC50 = 34 nM
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CP0404936
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N-[2-[[(3R)-1-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C22H24F3N3O3
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2
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| 1 |
IC50 = 35 nM
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| 2 |
IC50 = 114 nM
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CP0482147
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CHEMBL1829609
Show/Hide
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C25H28F3N3O2
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1
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| 1 |
IC50 = 35 nM
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CP0472546
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N-[2-[[1-[4-(3-aminopyridin-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C24H28F3N5O2
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2
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| 1 |
IC50 = 35 nM
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| 2 |
IC50 = 43 nM
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CP0125748
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N-[4-chloro-3-(trifluoromethyl)phenyl]-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C21H28ClF3N4O
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2
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| 1 |
IC50 = 35 nM
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| 2 |
IC50 = 421 nM
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CP0385296
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3-[1-[(3aS,5S,6aR)-3a-[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazine-3-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl]piperidin-4-yl]benzoic acid
Show/Hide
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C29H31F3N2O5
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1
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| 1 |
IC50 = 35 nM
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CP0389102
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N-[2-[[1-(4-hydroxy-4-phenylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H28F3N3O3
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2
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| 1 |
IC50 = 36 nM
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| 2 |
IC50 = 55 nM
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CP0397648
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N-[2-[[1-[4-hydroxy-4-(1,2-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C22H25F3N4O3S
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1
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| 1 |
IC50 = 36 nM
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CP0318896
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N-[1-[4-(3-aminopyridin-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
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C25H28F3N7O
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1
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| 1 |
IC50 = 36 nM
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CP0160834
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(S)-N-(2-(3-(4-bromo-2-methylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide
Show/Hide
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C25H31BrF3N5O3
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1
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| 1 |
IC50 = 37 nM
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CP0332577
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N-(3,4-dichlorophenyl)-4-[[(3R)-1-ethylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C19H28Cl2N4O
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2
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| 1 |
IC50 = 37 nM
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| 2 |
IC50 = 174 nM
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CP0056489
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N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamide
Show/Hide
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C23H25F3N6O2S
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1
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| 1 |
IC50 = 38 nM
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CP0248676
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2-[[2,6-bis(trifluoromethyl)quinazolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
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C24H24F6N6O2S
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1
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| 1 |
IC50 = 39 nM
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CP0202906
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1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-cyclopropylprop-2-yn-1-one
Show/Hide
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C29H35F3N4O4
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1
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| 1 |
IC50 = 39 nM
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CP0435238
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cyclopentyl-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]-dimethylazanium
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C21H25Cl2N2O+
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1
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| 1 |
IC50 = 40 nM
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CP0310758
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N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
|
C23H25F3N6O2S
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1
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| 1 |
IC50 = 40 nM
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CP0964732
|
US8921559, 40
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C27H32Cl2N6O2
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1
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| 1 |
IC50 = 40 nM
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CP0376846
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N-[2-[[1-[4-hydroxy-4-(2-methylsulfanyl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C23H27F3N4O3S2
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2
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| 1 |
IC50 = 41 nM
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| 2 |
IC50 = 68 nM
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CP0317447
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2-methoxyethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C27H37F3N4O6
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1
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| 1 |
IC50 = 41 nM
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CP0871024
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4-[(2R)-4-tert-Butylpiperazine-2-carbonyl]-N-(5-methoxy-4-methyl-thiazol-2-yl)piperazine-1-carboxamide
Show/Hide
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C19H32N6O3S
|
1
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| 1 |
IC50 = 41 nM
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CP0427838
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2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-nitrobenzamide
Show/Hide
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C20H22ClN5O4
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2
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| 1 |
IC50 = 43 nM
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| 2 |
IC50 = 208 nM
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CP0516057
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2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethoxy)benzamide
Show/Hide
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C21H22ClF3N4O3
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2
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| 1 |
IC50 = 43 nM
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| 2 |
IC50 = 88 nM
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CP0499130
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N-[2-oxo-2-[[1-(4-pyrazin-2-ylcyclohexyl)azetidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C23H26F3N5O2
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1
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| 1 |
IC50 = 44 nM
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CP0472540
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N-[1-[4-(hydroxymethyl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
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C21H28F3N5O2
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2
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| 1 |
IC50 = 44 nM
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| 2 |
IC50 = 47 nM
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CP0381318
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N-[2-[[1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H29F3N4O4
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2
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| 1 |
IC50 = 44 nM
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| 2 |
IC50 = 56 nM
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CP0397645
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N-[2-[[1-[4-hydroxy-4-(6-propan-2-yloxypyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H33F3N4O4
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2
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| 1 |
IC50 = 44 nM
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| 2 |
IC50 = 50 nM
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CP0473589
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N-[2-oxo-2-[[1-(4-pyridin-3-ylcyclohexyl)azetidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C24H27F3N4O2
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2
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| 1 |
IC50 = 45 nM
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| 2 |
IC50 = 52 nM
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CP0462092
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N-[2-[[1-[4-hydroxy-4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H29F3N4O3
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2
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| 1 |
IC50 = 45 nM
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| 2 |
IC50 = 74 nM
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CP0144619
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[(2R,3aR,6aR)-2-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
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C24H32F3N3O3
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1
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| 1 |
IC50 = 49 nM
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CP0338509
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N-(3-chloro-4-fluorophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C20H28ClFN4O
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2
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| 1 |
IC50 = 50 nM
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| 2 |
IC50 = 75 nM
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CP0156848
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2-[[2,6-bis(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamide
Show/Hide
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C25H25F6N5O2S
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1
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| 1 |
IC50 = 50 nM
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CP0093140
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N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[propan-2-yl(propyl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C31H40F3N3O4S
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1
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| 1 |
IC50 = 51 nM
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CP0199851
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(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-amino-5-(trifluoromethyl)benzamide
Show/Hide
|
C26H34F3N5O3
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1
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| 1 |
IC50 = 52 nM
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CP0201872
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(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H33F3N4O3
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1
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| 1 |
IC50 = 52 nM
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CP0513005
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N-[2-[[1-[4-(3-hydroxypyridin-4-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C24H27F3N4O3
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2
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| 1 |
IC50 = 52 nM
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| 2 |
IC50 = 57 nM
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CP0306781
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4-[[(3R)-1-(cyclopropylmethyl)piperidin-3-yl]methyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
Show/Hide
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C21H30Cl2N4O
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2
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| 1 |
IC50 = 52 nM
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| 2 |
IC50 = 161 nM
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CP0193412
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N-[1-[4-hydroxy-4-(6-methoxypyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Show/Hide
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C26H29F3N6O3
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1
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| 1 |
IC50 = 56 nM
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CP0528311
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(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-(benzylamino)-5-(trifluoromethyl)benzamide
Show/Hide
|
C33H40F3N5O3
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1
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| 1 |
IC50 = 57 nM
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CP0396533
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N-[2-[[1-[4-hydroxy-4-(2-propan-2-yl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H31F3N4O3S
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2
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| 1 |
IC50 = 57 nM
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| 2 |
IC50 = 70 nM
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CP0136162
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(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(ethylamino)-5-(trifluoromethyl)benzamide
Show/Hide
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C28H38F3N5O3
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1
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| 1 |
IC50 = 58 nM
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CP0185497
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(S)-1-(2-((2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)carbamoyl)-4-(trifluoromethyl)phenyl)-3-isopropylurea
Show/Hide
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C30H41F3N6O4
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1
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| 1 |
IC50 = 58 nM
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CP0290749
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N-(4-bromophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C20H29BrN4O
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2
|
| 1 |
IC50 = 58 nM
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| 2 |
IC50 = 162 nM
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CP0945626
|
US8921559, 19
Show/Hide
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C31H39N5O4
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1
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| 1 |
IC50 = 58 nM
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CP0403498
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[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,2-dimethyl-4,5,6,6a-tetrahydro-3H-cyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C25H34F3N3O4
|
1
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| 1 |
IC50 = 59 nM
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CP0458354
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N-[2-oxo-2-[[1-[4-(4-pyrrolidin-1-ylphenyl)cyclohexyl]azetidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C29H35F3N4O2
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2
|
| 1 |
IC50 = 61 nM
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| 2 |
IC50 = 240 nM
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CP0385295
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[(3aS,5S,6aR)-5-(oxan-4-ylamino)-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C22H28F3N3O3
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1
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| 1 |
IC50 = 62 nM
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CP0384583
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N-[1-[4-(2-oxopyridin-1-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C24H27F3N6O2
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2
|
| 1 |
IC50 = 63 nM
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| 2 |
IC50 = 170 nM
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CP0257691
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N-(3,4-dichlorophenyl)-4-[[(3R)-1-(3-phenylpropyl)piperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C26H34Cl2N4O
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2
|
| 1 |
IC50 = 64 nM
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| 2 |
IC50 = 280 nM
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CP0338508
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N-(3,4-dichlorophenyl)-4-[[(2S)-4-ethylmorpholin-2-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C18H26Cl2N4O2
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2
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| 1 |
IC50 = 64 nM
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| 2 |
IC50 = 277 nM
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CP0397644
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N-[2-[[1-[4-(2-ethyl-1,3-thiazol-5-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H29F3N4O3S
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2
|
| 1 |
IC50 = 65 nM
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| 2 |
IC50 = 78 nM
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CP0219341
|
oxan-4-ylmethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C30H41F3N4O6
|
1
|
| 1 |
IC50 = 65 nM
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CP0498751
|
ethyl 4-[3-[[2-[[3-benzyl-6-(trifluoromethyl)-2,3-dihydroisoindol-1-ylidene]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C30H35F3N4O3
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2
|
| 1 |
IC50 = 67 nM
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| 2 |
IC50 = 170 nM
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CP0271223
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4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Show/Hide
|
C21H29F3N4O
|
2
|
| 1 |
IC50 = 68 nM
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| 2 |
IC50 = 593 nM
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CP0215141
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(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O3
|
1
|
| 1 |
IC50 = 69 nM
|
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CP0441096
|
N-(3,4-dichlorophenyl)-4-[(2R)-4-methylpiperazine-2-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C17H23Cl2N5O2
|
2
|
| 1 |
IC50 = 69 nM
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| 2 |
IC50 = 362 nM
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|
|
|
CP0258416
|
methyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C25H33F3N4O5
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0473587
|
4-[4-[3-[[2-[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]benzoic acid
Show/Hide
|
C26H28F3N3O4
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0381317
|
N-[2-[[1-[4-hydroxy-4-(6-methoxypyridin-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O4
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0176444
|
(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-methyl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Show/Hide
|
C25H34F3N5O4
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0316081
|
N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinolin-4-yl]amino]acetamide
Show/Hide
|
C24H26F3N5O2S
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0546246
|
N-[2-[[(3R)-1-[(2-naphthalen-2-ylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H28F3N3O2
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
IC50 = 759 nM
|
|
|
|
CP0920581
|
US8921559, 10
Show/Hide
|
C31H35F3N4O2
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0422358
|
N-[2-[[(3R)-1-[(4-hydroxy-3-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O4
|
2
|
| 1 |
IC50 = 77 nM
|
|
|
| 2 |
IC50 = 153 nM
|
|
|
|
CP0454125
|
(E)-N-((1S,3R)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)-3-(3,4,5-trifluorophenyl)acrylamide
Show/Hide
|
C27H31F3N2O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0681545
|
1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea Hydrochloride
Show/Hide
|
C24H34ClN7O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0438304
|
methyl 4-[4-[3-[[2-[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]benzoate
Show/Hide
|
C27H30F3N3O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0347344
|
(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-propan-2-yl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Show/Hide
|
C27H38F3N5O4
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0487157
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[5-[4-(trifluoromethyl)pyrimidin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
Show/Hide
|
C24H32F3N5O4
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0208642
|
(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-amino-1-oxopropan-2-ylamino)-2-oxoethyl)-2-amino-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H26F3N5O3
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0870801
|
US8921559, 41
Show/Hide
|
C29H32F3N5O2
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0202246
|
(S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-2-(ethylamino)-5-(trifluoromethyl)benzamide
Show/Hide
|
C28H38F3N5O3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0484969
|
N-[2-[[1-[4-(5-aminopyridin-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H28F3N5O2
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0176445
|
1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylpropan-1-one
Show/Hide
|
C32H39F3N4O4
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0930773
|
US8921559, 42
Show/Hide
|
C27H32Cl2N6O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0085707
|
(E)-1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-4,4-dimethylpent-2-en-1-one
Show/Hide
|
C30H41F3N4O4
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0167981
|
N-[2-[[(1S,3S,4R)-3-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H34F3N3O4S
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0453923
|
2-bicyclo[2.2.1]heptanyl-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]-dimethylazanium
Show/Hide
|
C23H27Cl2N2O+
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0176443
|
[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-phenyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C29H35F3N4O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0404939
|
2-amino-N-[2-[[(3R)-1-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C21H21Cl2F3N4O2
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0258415
|
2-morpholin-4-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C30H42F3N5O6
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0338754
|
4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Show/Hide
|
C21H29F3N4O
|
2
|
| 1 |
IC50 = 98 nM
|
|
|
| 2 |
IC50 = 578 nM
|
|
|
|
CP0532319
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2,5-dioxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C29H34F3N3O5S
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0306783
|
4-[[(3R)-1-benzylpiperidin-3-yl]methyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
Show/Hide
|
C24H30Cl2N4O
|
2
|
| 1 |
IC50 = 99 nM
|
|
|
| 2 |
IC50 = 244 nM
|
|
|
|
CP0155510
|
2,2-dimethylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C29H41F3N4O5
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0504522
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-((3S,4S)-3-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C24H32F6N2O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0507730
|
N-[2-[[1-(4-hydroxy-4-thiophen-2-ylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H26F3N3O3S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0525689
|
N-[2-oxo-2-[[(3R)-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H21F6N3O3
|
2
|
| 1 |
IC50 = 103 nM
|
|
|
| 2 |
IC50 = 610 nM
|
|
|
|
CP0458350
|
N-[2-[[1-(4-fluoro-4-phenylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H27F4N3O2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
|
CP0522841
|
[4-[(7-chloro-2H-chromene-3-carbonyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C24H28ClN2O3+
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0494299
|
N-[1-(4-cyclohexylcyclohexyl)azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C26H36F3N5O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0961346
|
US8921559, 12
Show/Hide
|
C33H40N4O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0485899
|
N-[2-[[(3R)-1-[(4-fluorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H21F4N3O2
|
2
|
| 1 |
IC50 = 121 nM
|
|
|
| 2 |
IC50 = 960 nM
|
|
|
|
CP0930774
|
US8921559, 43
Show/Hide
|
C29H35N5O2
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0880829
|
rac-N-(3,4-dichlorophenyl)-4-((1-ethylpiperidin-3-yl)methyl)piperazine-1-carboxamide
Show/Hide
|
C19H28Cl2N4O
|
2
|
| 1 |
IC50 = 123 nM
|
|
|
| 2 |
IC50 = 627 nM
|
|
|
|
CP0427836
|
N-[2-[[(3R)-1-[(2-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O2
|
2
|
| 1 |
IC50 = 127 nM
|
|
|
| 2 |
IC50 = 960 nM
|
|
|
|
CP0280558
|
N-(4-chlorophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C20H29ClN4O
|
2
|
| 1 |
IC50 = 127 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0513810
|
(E)-N-(3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)-3-(3,4,5-trifluorophenyl)acrylamide
Show/Hide
|
C27H31F3N2O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0335721
|
2-[1-[(E)-3-(4-chlorophenyl)prop-2-enoyl]piperidin-4-yl]-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]acetamide
Show/Hide
|
C30H35ClN4O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0920599
|
US8921559, 45
Show/Hide
|
C29H33F2N5O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0943626
|
US8921559, 9
Show/Hide
|
C29H34F3N5O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0671784
|
2-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)cyclohexylamino)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetamide
Show/Hide
|
C29H32F3N5O2
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0332361
|
2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C31H35F3N4O2
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0551878
|
(E)-3-(3,4-dichlorophenyl)-N-(3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0454987
|
N-[1-[4-(1-methylpyrazol-3-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C24H30F3N7O
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0478661
|
N-[1-(4-ethoxycyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C21H28F3N5O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0953408
|
US8921559, 15
Show/Hide
|
C32H38N4O3
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0945625
|
US8921559, 16
Show/Hide
|
C29H34F3N5O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0294073
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]benzamide
Show/Hide
|
C28H37N3O4S
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0516154
|
(E)-3-(3,5-dichlorophenyl)-N-((1S,3R)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0551875
|
(E)-3-(3,5-difluorophenyl)-N-((1S,3R)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32F2N2O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0438305
|
N-[2-[[1-(4-amino-4-phenylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O2
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0553859
|
dimethyl-[[4-[(7-methyl-2H-chromene-3-carbonyl)amino]phenyl]methyl]-(oxan-4-yl)azanium
Show/Hide
|
C25H31N2O3+
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0125751
|
N-(3,4-dichlorophenyl)-4-[(1-methylpiperidin-3-yl)methyl]piperazine-1-carboxamide
Show/Hide
|
C18H26Cl2N4O
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 = 965 nM
|
|
|
|
CP0447903
|
N-[2-[[1-[4-(6-cyanopyridin-3-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H26F3N5O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0416572
|
N-(3-chlorophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C20H29ClN4O
|
2
|
| 1 |
IC50 = 171 nM
|
|
|
| 2 |
IC50 = 202 nM
|
|
|
|
CP0911248
|
US8921559, 17
Show/Hide
|
C31H34F2N4O4
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0516524
|
(E)-3-(3,5-dichlorophenyl)-N-(3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0522842
|
[4-[(7-bromo-2H-chromene-3-carbonyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C24H28BrN2O3+
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0440590
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[5-[6-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
Show/Hide
|
C25H33F3N4O4
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0508629
|
N-[2-[[1-(4-hydroxy-4-pyridin-3-ylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H27F3N4O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0381319
|
N-[2-[[1-[4-(6-fluoropyridin-3-yl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H26F4N4O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0339382
|
benzyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
|
C31H37F3N4O5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0406274
|
[(3aS,5S,6aR)-5-[3-hydroxypropyl-(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C26H36F3N3O5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0332360
|
2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-phenylprop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C30H36N4O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0382226
|
[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(thian-4-yl)azanium
Show/Hide
|
C21H25Cl2N2OS+
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0512991
|
N-[1-(4-prop-2-enoxycyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C22H28F3N5O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0452307
|
N-[2-[[1-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H27F4N3O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0499606
|
N-[2-[[1-[4-hydroxy-4-(6-methoxy-5-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H31F3N4O4
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0069637
|
(3aR,5R,6aR)-N-benzyl-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Show/Hide
|
C31H38F3N5O4
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0943628
|
US8921559, 25
Show/Hide
|
C30H33F2N3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0511688
|
[4-[(3-chlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H26ClN2O2+
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0499063
|
ethyl 4-[3-[[2-[[1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C24H29F6N5O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0346051
|
1-[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]ethanone
Show/Hide
|
C25H33F3N4O4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0957735
|
US8921559, 27
Show/Hide
|
C28H32Cl2N4O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0551876
|
(E)-3-(3,5-difluorophenyl)-N-(3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32F2N2O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0382267
|
[4-[(3-bromobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H26BrN2O2+
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0397628
|
N-[2-[[1-[4-hydroxy-4-(5-methoxypyridin-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H29F3N4O4
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0271222
|
4-[[(2S)-4-cyclopropylmorpholin-2-yl]methyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
Show/Hide
|
C19H26Cl2N4O2
|
2
|
| 1 |
IC50 = 262 nM
|
|
|
| 2 |
IC50 = 267 nM
|
|
|
|
CP0943627
|
US8921559, 11
Show/Hide
|
C29H34F3N5O3
|
1
|
| 1 |
IC50 = 264 nM
|
|
|
|
CP0036247
|
2-[1-[(E)-3-(2-fluorophenyl)prop-2-enoyl]piperidin-4-yl]-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]acetamide
Show/Hide
|
C30H35FN4O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0430734
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-(dimethylamino)cyclohexyl]-2-oxopiperidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H34F3N3O4S
|
1
|
| 1 |
IC50 = 284 nM
|
|
|
|
CP0427833
|
N-[2-[[(3R)-1-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H20Cl2F3N3O2
|
2
|
| 1 |
IC50 = 286 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0454921
|
cycloheptyl-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]-dimethylazanium
Show/Hide
|
C23H29Cl2N2O+
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0499077
|
N-[1-(4-phenylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]sulfanyl]acetamide
Show/Hide
|
C25H27F3N4OS
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0034619
|
(E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl)piperidin-1-yl)-3-(3,4-dichlorophenyl)prop-2-en-1-one
Show/Hide
|
C26H29Cl3N2O
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0433286
|
N-[2-[[(3R)-1-[(4-acetamidophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H25F3N4O3
|
1
|
| 1 |
IC50 = 305 nM
|
|
|
|
CP0465376
|
N-[2-[[1-[4-[6-(dimethylamino)pyridin-3-yl]-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H32F3N5O3
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0560088
|
(E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0155511
|
[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C24H33F3N4O3
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0957949
|
US8921559, 28
Show/Hide
|
C28H32Cl2N4O3
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0396854
|
N-[1-(4-cyanocyclohexyl)azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C21H25F3N6O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0385192
|
[(3aS,5S,6aR)-5-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]methanone
Show/Hide
|
C23H32F3N5O4
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0902252
|
US8921559, 46
Show/Hide
|
C29H33F2N5O2
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0440589
|
[(3aS,5S,6aR)-5-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[5-[2-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
Show/Hide
|
C24H32F3N5O4
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0516058
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethoxy)benzamide
Show/Hide
|
C21H21ClF3N3O3
|
2
|
| 1 |
IC50 = 360 nM
|
|
|
| 2 |
IC50 = 489 nM
|
|
|
|
CP0425454
|
N-[1-(4-propan-2-ylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C22H30F3N5O
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0379860
|
3-[1-[(3aS,5S,6aR)-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl]piperidin-4-yl]benzoic acid
Show/Hide
|
C29H32F3N3O4
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0872008
|
US8921559, 20
Show/Hide
|
C28H34FN5O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0454922
|
[4-[(3-chloro-4-fluorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25ClFN2O2+
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0484968
|
N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C25H29N3O4
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0887071
|
US8921559, 24
Show/Hide
|
C31H35F2N3O3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0943629
|
US8921559, 37
Show/Hide
|
C30H33F3N4O2
|
1
|
| 1 |
IC50 = 406 nM
|
|
|
|
CP0468466
|
CHEMBL1829630
Show/Hide
|
C26H27F3N4O3
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0444337
|
N-[2-[[(3R)-1-benzylpyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H22F3N3O2
|
2
|
| 1 |
IC50 = 418 nM
|
|
|
| 2 |
IC50 = 690 nM
|
|
|
|
CP0538532
|
N-[2-[[(3R)-1-[(2-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H21ClF3N3O2
|
2
|
| 1 |
IC50 = 418 nM
|
|
|
| 2 |
IC50 = 630 nM
|
|
|
|
CP0427839
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-nitrobenzamide
Show/Hide
|
C20H21ClN4O4
|
2
|
| 1 |
IC50 = 445 nM
|
|
|
| 2 |
IC50 = 832 nM
|
|
|
|
CP0161063
|
N-(4-cyanophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C21H29N5O
|
2
|
| 1 |
IC50 = 449 nM
|
|
|
| 2 |
IC50 = 4360 nM
|
|
|
|
CP0433284
|
3-bromo-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H21BrClN3O2
|
2
|
| 1 |
IC50 = 473 nM
|
|
|
| 2 |
IC50 = 785 nM
|
|
|
|
CP0471084
|
CHEMBL1834849
Show/Hide
|
C23H27F3N6O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0236183
|
2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C31H35F3N4O3
|
1
|
| 1 |
IC50 = 492 nM
|
|
|
|
CP0513813
|
(E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-hydroxyphenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H30Cl2N2O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0458836
|
N-[1-(4-phenylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]oxy]acetamide
Show/Hide
|
C25H27F3N4O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0494297
|
4-[3-[[2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxamide
Show/Hide
|
C21H27F3N6O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0458835
|
N-[1-(4-hydroxycyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C19H24F3N5O2
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0920582
|
US8921559, 22
Show/Hide
|
C31H39N5O4
|
1
|
| 1 |
IC50 = 553 nM
|
|
|
|
CP0306776
|
N-(3,4-dichlorophenyl)-4-[(3R)-1-ethylpiperidine-3-carbonyl]piperazine-1-carboxamide
Show/Hide
|
C19H26Cl2N4O2
|
2
|
| 1 |
IC50 = 588 nM
|
|
|
| 2 |
IC50 = 856 nM
|
|
|
|
CP0956770
|
US8921559, 48
Show/Hide
|
C28H36N6O2
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0957948
|
US8921559, 23
Show/Hide
|
C32H38N4O4
|
1
|
| 1 |
IC50 = 602 nM
|
|
|
|
CP0060126
|
2-[[4-(6-methoxypyridin-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-(3,4,5-trifluorophenyl)prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C28H33F3N4O3
|
1
|
| 1 |
IC50 = 635 nM
|
|
|
|
CP0404944
|
2-amino-5-bromo-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H22BrClN4O2
|
1
|
| 1 |
IC50 = 643 nM
|
|
|
|
CP0498750
|
ethyl 4-[3-[[2-[[1-cyclopentyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C27H36F3N5O3
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0462091
|
N-[2-[[1-(4-hydroxy-4-pyrimidin-5-ylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H26F3N5O3
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0221905
|
N-hydroxy-2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-2-[1-[(E)-3-(3,4,5-trifluorophenyl)prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
|
C30H33F3N4O3
|
1
|
| 1 |
IC50 = 665 nM
|
|
|
|
CP0945627
|
US8921559, 29
Show/Hide
|
C28H34FN5O2
|
1
|
| 1 |
IC50 = 669 nM
|
|
|
|
CP0378480
|
1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea
Show/Hide
|
C17H13F4N5O2
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0919393
|
US8921559, 30
Show/Hide
|
C28H32F3N5O2
|
1
|
| 1 |
IC50 = 708 nM
|
|
|
|
CP0277285
|
3-{1-Hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-propyl}-phenol
Show/Hide
|
C28H34N2O4S
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0409452
|
[4-[(3,5-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25Cl2N2O2+
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0436486
|
4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-phenylpiperazine-1-carboxamide
Show/Hide
|
C20H30N4O
|
2
|
| 1 |
IC50 = 710 nM
|
|
|
| 2 |
IC50 > 3000 nM
|
|
|
|
CP0919394
|
US8921559, 31
Show/Hide
|
C29H37N5O2S
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0525712
|
2-amino-5-chloro-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H22Cl2N4O2
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0964731
|
US8921559, 3
Show/Hide
|
C30H34F2N4O2
|
1
|
| 1 |
IC50 = 740 nM
|
|
|
|
CP0069634
|
[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H31F3N4O3
|
1
|
| 1 |
IC50 = 770 nM
|
|
|
|
CP0332578
|
N-(3,4-dichlorophenyl)-4-(piperidin-3-ylmethyl)piperazine-1-carboxamide
Show/Hide
|
C17H24Cl2N4O
|
2
|
| 1 |
IC50 = 780 nM
|
|
|
| 2 |
IC50 = 950 nM
|
|
|
|
CP0457722
|
(E)-3-(3,5-difluorophenyl)-N-(3-((4-(3,4-difluorophenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C26H28F4N2O
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0499426
|
N-[2-[[1-[4-hydroxy-4-(1,3,4-thiadiazol-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C21H24F3N5O3S
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0271221
|
N-(3,4-dichlorophenyl)-4-[(4-ethylpiperazin-2-yl)methyl]piperazine-1-carboxamide
Show/Hide
|
C18H27Cl2N5O
|
1
|
| 1 |
IC50 = 797 nM
|
|
|
|
CP0961347
|
US8921559, 32
Show/Hide
|
C28H33F2N5O2
|
1
|
| 1 |
IC50 = 807 nM
|
|
|
|
CP0435916
|
ethyl 4-[3-[[2-[[1-methylsulfonyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
Show/Hide
|
C23H30F3N5O5S
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0371697
|
(E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-(dimethylamino)phenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
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C28H35Cl2N3O
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1
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| 1 |
IC50 = 950 nM
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CP0154057
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phenyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Show/Hide
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C30H35F3N4O5
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1
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| 1 |
IC50 = 950 nM
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CP0470193
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US8921559, 52
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C30H35F3N4O2
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1
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| 1 |
IC50 = 950 nM
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CP0961348
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US8921559, 33
Show/Hide
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C33H40N4O3
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1
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| 1 |
IC50 = 960 nM
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CP0238006
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2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-N,N-dimethyl-2-[1-[(E)-3-(3,4,5-trifluorophenyl)prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
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C32H37F3N4O2
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1
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| 1 |
IC50 = 981 nM
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CP0338188
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2-[[4-(1H-indol-3-yl)cyclohexyl]amino]-N-methyl-2-[1-[(E)-3-(3,4,5-trifluorophenyl)prop-2-enoyl]piperidin-4-yl]acetamide
Show/Hide
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C31H35F3N4O2
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1
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| 1 |
IC50 = 984 nM
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CP0550926
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1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-isopropoxyphenyl)urea
Show/Hide
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C18H18N2O5
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1
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| 1 |
IC50 = 1000 nM
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CP0473588
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N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohex-3-en-1-yl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C26H26F3N3O4
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1
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| 1 |
IC50 = 1000 nM
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CP0502041
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[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-ylmethyl)azanium
Show/Hide
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C22H27Cl2N2O2+
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1
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| 1 |
IC50 = 1020 nM
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CP0338752
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N-(3-cyanophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C21H29N5O
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2
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| 1 |
IC50 = 1055 nM
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| 2 |
IC50 = 5870 nM
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CP0954680
|
US8921559, 34
Show/Hide
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C34H42N4O3
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1
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| 1 |
IC50 = 1098 nM
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CP0050199
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N-(3,4-dichlorophenyl)-4-[[(3S)-1-ethylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
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C19H28Cl2N4O
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1
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| 1 |
IC50 = 1184 nM
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CP0393076
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(E)-N-(5-(4-(4-chlorophenyl)piperidin-1-yl)pentyl)-3-(3,4-dichlorophenyl)acrylamide
Show/Hide
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C25H29Cl3N2O
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1
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| 1 |
IC50 = 1200 nM
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CP0452303
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N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-4-(trifluoromethyl)benzamide
Show/Hide
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C26H28F3N3O4
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1
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| 1 |
IC50 = 1200 nM
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CP0492704
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[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-(1,3-thiazol-2-yl)-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
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C26H31F3N4O4S
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1
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| 1 |
IC50 = 1280 nM
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CP0444338
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N-[2-[[(3R)-1-[(2-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C22H24F3N3O3
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1
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| 1 |
IC50 = 1360 nM
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CP0464115
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(E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl)piperidin-1-yl)-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-one
Show/Hide
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C27H30ClF3N2O
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1
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| 1 |
IC50 = 1400 nM
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CP0396851
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N-[1-[4-(1-methylimidazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
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C24H30F3N7O
|
1
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| 1 |
IC50 = 1400 nM
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CP0338379
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4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-(4-methoxyphenyl)piperazine-1-carboxamide
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C21H32N4O2
|
1
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| 1 |
IC50 = 1458 nM
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CP0439837
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4-{4-[3-Hydroxy-3-(3-hydroxy-phenyl)-3-phenyl-propyl]-[1,4]diazepan-1-ylmethyl}-benzenesulfonamide
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C27H33N3O4S
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1
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| 1 |
IC50 = 1500 nM
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CP0442389
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3-{1-(4-Chloro-phenyl)-1-hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propyl}-phenol
Show/Hide
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C28H33ClN2O4S
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1
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| 1 |
IC50 = 1500 nM
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CP0485151
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3-{1-(4-Fluoro-phenyl)-1-hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propyl}-phenol
Show/Hide
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C28H33FN2O4S
|
1
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| 1 |
IC50 = 1500 nM
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CP0501209
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1,1-di(3-hydroxyphenyl)-3-[4-(4-methylsulfonylbenzyl)-1,4-diazepan-1-yl]-1-propanol
Show/Hide
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C28H34N2O5S
|
1
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| 1 |
IC50 = 1500 nM
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CP0551880
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(E)-3-(3,4-dichlorophenyl)-N-(5-(4-(4-methoxyphenyl)piperidin-1-yl)pentyl)acrylamide
Show/Hide
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C26H32Cl2N2O2
|
1
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| 1 |
IC50 = 1500 nM
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CP0511348
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1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3,4-dichlorophenyl)urea
Show/Hide
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C15H10Cl2N2O4
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1
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| 1 |
IC50 = 1500 nM
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CP0516445
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1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-(trifluoromethyl)phenyl)urea
Show/Hide
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C16H11F3N2O4
|
1
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| 1 |
IC50 = 1500 nM
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CP0457194
|
N-[2-[[(3R)-1-[(4-nitrophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C21H21F3N4O4
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1
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| 1 |
IC50 = 1550 nM
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CP0473273
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophenyl)urea
Show/Hide
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C15H11ClN2O4
|
1
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| 1 |
IC50 = 1600 nM
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CP0457732
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(E)-N-(5-(4-(4-chlorophenyl)piperidin-1-yl)pentyl)-3-(4-fluorophenyl)acrylamide
Show/Hide
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C25H30ClFN2O
|
1
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| 1 |
IC50 = 1800 nM
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CP0505060
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N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H28F3N3O4
|
1
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| 1 |
IC50 = 1800 nM
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CP0522843
|
[4-[[(E)-3-(3-fluorophenyl)prop-2-enoyl]amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
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C23H28FN2O2+
|
1
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| 1 |
IC50 = 1810 nM
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CP0378281
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(E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-3-(3,4,5-trifluorophenyl)acrylamide
Show/Hide
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C24H26ClF3N2O
|
1
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| 1 |
IC50 = 1900 nM
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CP0458643
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(E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl)piperidin-1-yl)-3-(3,4-difluorophenyl)prop-2-en-1-one
Show/Hide
|
C26H29ClF2N2O
|
1
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| 1 |
IC50 = 2000 nM
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CP0502043
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[4-[(4-chlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
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C21H26ClN2O2+
|
1
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| 1 |
IC50 = 2000 nM
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CP0454923
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dimethyl-(oxan-4-yl)-[[4-[[3-(trifluoromethyl)benzoyl]amino]phenyl]methyl]azanium
Show/Hide
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C22H26F3N2O2+
|
1
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| 1 |
IC50 = 2050 nM
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CP0472539
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N-[1-[4-(methanesulfonamido)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C20H27F3N6O3S
|
1
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| 1 |
IC50 = 2080 nM
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CP0464117
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(E)-3-(4-fluorophenyl)-N-(5-(4-(4-methoxyphenyl)piperidin-1-yl)pentyl)acrylamide
Show/Hide
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C26H33FN2O2
|
1
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| 1 |
IC50 = 2100 nM
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CP0411742
|
4-[1-[(3aS,5S,6aR)-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl]piperidin-4-yl]benzoic acid
Show/Hide
|
C29H32F3N3O4
|
1
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| 1 |
IC50 = 2130 nM
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CP0513812
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(E)-3-(3,4-dichlorophenyl)-1-(4-((4-p-tolylpiperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C27H32Cl2N2O
|
1
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| 1 |
IC50 = 2200 nM
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CP0397220
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benzyl (3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]pyrrole-1-carboxylate
Show/Hide
|
C31H37F3N4O5
|
1
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| 1 |
IC50 = 2200 nM
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CP0458671
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(E)-3-(4-fluorophenyl)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)acrylamide
Show/Hide
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C25H31FN2O2
|
1
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| 1 |
IC50 = 2300 nM
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CP0433285
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N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-methylbenzamide
Show/Hide
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C21H24ClN3O2
|
1
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| 1 |
IC50 = 2380 nM
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CP0377908
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3-{1-(3-Fluoro-phenyl)-1-hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propyl}-phenol
Show/Hide
|
C28H33FN2O4S
|
1
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| 1 |
IC50 = 2400 nM
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CP0382088
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3-chloro-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
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C20H21Cl2N3O2
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1
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| 1 |
IC50 = 2400 nM
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CP0409453
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[4-[[(E)-3-(3,4-dichlorophenyl)prop-2-enoyl]amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
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C23H27Cl2N2O2+
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1
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| 1 |
IC50 = 2550 nM
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CP0050196
|
N-(3,4-dichlorophenyl)-4-(4-ethylmorpholine-2-carbonyl)piperazine-1-carboxamide
Show/Hide
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C18H24Cl2N4O3
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2
|
| 1 |
IC50 = 2570 nM
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| 2 |
IC50 > 1000 nM
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CP0513814
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(E)-3-(3,4-dichlorophenyl)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)acrylamide
Show/Hide
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C25H30Cl2N2O2
|
1
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| 1 |
IC50 = 2600 nM
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CP0494298
|
4-[3-[[2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylic acid
Show/Hide
|
C21H26F3N5O3
|
1
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| 1 |
IC50 = 2600 nM
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CP0404945
|
N-[2-[[(3R)-1-[(4-cyanophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H21F3N4O2
|
1
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| 1 |
IC50 = 2650 nM
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CP0447904
|
CHEMBL2204256
Show/Hide
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C23H28F3N5O3
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1
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| 1 |
IC50 = 2700 nM
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CP0521835
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N-[2-[[1-[4-hydroxy-4-(1,3-oxazol-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H25F3N4O4
|
1
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| 1 |
IC50 = 2820 nM
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CP0513811
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(E)-1-(4-(2-(4-(4-chlorophenyl)piperidin-1-yl)ethyl)piperidin-1-yl)-3-(3,4-dichlorophenyl)prop-2-en-1-one
Show/Hide
|
C27H31Cl3N2O
|
1
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| 1 |
IC50 = 2900 nM
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CP0551882
|
(E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-3-(3,4-dichlorophenyl)acrylamide
Show/Hide
|
C24H27Cl3N2O
|
1
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| 1 |
IC50 = 2900 nM
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CP0464114
|
(E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-3-(4-fluorophenyl)acrylamide
Show/Hide
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C24H28ClFN2O
|
1
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| 1 |
IC50 = 3100 nM
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CP0485901
|
N-[2-[[(3R)-1-[(3-methylphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O2
|
1
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| 1 |
IC50 = 3100 nM
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CP0404946
|
N-[2-[[(3R)-1-[(3-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H24F3N3O3
|
1
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| 1 |
IC50 = 3170 nM
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CP0492705
|
[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-cyclopenta[b]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H31F3N4O3
|
1
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| 1 |
IC50 = 3170 nM
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CP0553858
|
[4-[(3-cyanobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C22H26N3O2+
|
1
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| 1 |
IC50 = 3250 nM
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CP0378280
|
(E)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)-3-(3,4,5-trifluorophenyl)acrylamide
Show/Hide
|
C25H29F3N2O2
|
1
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| 1 |
IC50 = 3400 nM
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CP0553857
|
dimethyl-[[4-[[3-(4-methylphenyl)benzoyl]amino]phenyl]methyl]-(oxan-4-yl)azanium
Show/Hide
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C28H33N2O2+
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1
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| 1 |
IC50 = 3440 nM
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CP0551881
|
(E)-3-(3,5-difluorophenyl)-N-(4-(4-(4-methoxyphenyl)piperidin-1-yl)butyl)acrylamide
Show/Hide
|
C25H30F2N2O2
|
1
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| 1 |
IC50 = 3800 nM
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CP0447079
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chloro-4-hydroxyphenyl)urea
Show/Hide
|
C15H11ClN2O5
|
1
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| 1 |
IC50 = 3900 nM
|
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CP0480346
|
1-(3-Hydroxymethyl-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-propan-1-ol
Show/Hide
|
C29H36N2O4S
|
1
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| 1 |
IC50 = 4000 nM
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CP0490395
|
(E)-3-(3,4-dichlorophenyl)-1-(4-((4-(3-methoxyphenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C27H32Cl2N2O2
|
1
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| 1 |
IC50 = 4000 nM
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CP0399874
|
3-[4-(4-Methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1,1-diphenyl-propan-1-ol
Show/Hide
|
C28H34N2O3S
|
1
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| 1 |
IC50 = 4100 nM
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CP0496849
|
1-(3-Amino-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-propan-1-ol
Show/Hide
|
C28H35N3O3S
|
1
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| 1 |
IC50 = 4200 nM
|
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CP0530902
|
dimethyl-[[4-[(3-methylbenzoyl)amino]phenyl]methyl]-(oxan-4-yl)azanium
Show/Hide
|
C22H29N2O2+
|
1
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| 1 |
IC50 = 4250 nM
|
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CP0427832
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-fluorobenzamide
Show/Hide
|
C20H21ClFN3O2
|
1
|
| 1 |
IC50 = 4330 nM
|
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CP0405818
|
3-{1-(3-Chloro-phenyl)-1-hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propyl}-phenol
Show/Hide
|
C28H33ClN2O4S
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
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CP0464118
|
(E)-N-(4-(4-(4-chlorophenyl)piperidin-1-yl)butyl)-3-(3,5-dichlorophenyl)acrylamide
Show/Hide
|
C24H27Cl3N2O
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
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CP0471436
|
(4-benzamidophenyl)methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H27N2O2+
|
1
|
| 1 |
IC50 = 4750 nM
|
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|
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CP0487122
|
3-[4-(4-Methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-(3-methylamino-phenyl)-1-phenyl-propan-1-ol
Show/Hide
|
C29H37N3O3S
|
1
|
| 1 |
IC50 = 5000 nM
|
|
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CP0393075
|
(E)-3-(4-bromophenyl)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C26H30BrClN2O
|
1
|
| 1 |
IC50 = 5200 nM
|
|
|
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CP0499427
|
N-[2-[[1-[4-hydroxy-4-(1-methylimidazol-2-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C23H28F3N5O3
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0429878
|
CHEMBL1834579
Show/Hide
|
C25H27F3N4O2
|
1
|
| 1 |
IC50 = 5400 nM
|
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|
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CP0169867
|
N-(3,4-dichlorophenyl)-4-(1,4-dimethylpiperazine-2-carbonyl)piperazine-1-carboxamide
Show/Hide
|
C18H25Cl2N5O2
|
1
|
| 1 |
IC50 = 5500 nM
|
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CP0487154
|
[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-1-oxo-2,3,4,5,6,6a-hexahydrocyclopenta[b]thiophen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O4S
|
1
|
| 1 |
IC50 = 5700 nM
|
|
|
|
CP0551879
|
(E)-1-(4-((4-(4-chlorophenyl)piperidin-1-yl)methyl)piperidin-1-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
Show/Hide
|
C28H35ClN2O3
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0497346
|
4-Methyl-thiophene-2-carboxylic acid N''-(2-{4-[3-hydroxy-3-(3-hydroxy-phenyl)-3-phenyl-propyl]-[1,4]diazepan-1-yl}-acetyl)-hydrazide
Show/Hide
|
C28H34N4O4S
|
1
|
| 1 |
IC50 = 6400 nM
|
|
|
|
CP0551877
|
(E)-3-(3,5-dichlorophenyl)-N-((1R,3S)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 6450 nM
|
|
|
|
CP0515352
|
1,1-Bis-(4-fluoro-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propan-1-ol
Show/Hide
|
C28H32F2N2O3S
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0254041
|
4-Methyl-thiophene-2-carboxylic acid N''-{2-[4-(4-chloro-benzyl)-[1,4]diazepan-1-yl]-acetyl}-hydrazide
Show/Hide
|
C20H25ClN4O2S
|
1
|
| 1 |
IC50 = 7400 nM
|
|
|
|
CP0502042
|
[4-[(2,4-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25Cl2N2O2+
|
1
|
| 1 |
IC50 = 7800 nM
|
|
|
|
CP0487123
|
3-[4-(4-Methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-(3-methoxy-phenyl)-1-phenyl-propan-1-ol
Show/Hide
|
C29H36N2O4S
|
1
|
| 1 |
IC50 = 7900 nM
|
|
|
|
CP0513809
|
(E)-N-((1R,3S)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)-3-(3,4,5-trifluorophenyl)acrylamide
Show/Hide
|
C27H31F3N2O2
|
1
|
| 1 |
IC50 = 8400 nM
|
|
|
|
CP0553856
|
[4-[[(3,4-dichlorobenzoyl)amino]methyl]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C22H27Cl2N2O2+
|
1
|
| 1 |
IC50 = 8950 nM
|
|
|
|
CP0485502
|
3-{1-(3,5-Difluoro-phenyl)-1-hydroxy-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propyl}-phenol
Show/Hide
|
C28H32F2N2O4S
|
1
|
| 1 |
IC50 = 9300 nM
|
|
|
|
CP0530903
|
[4-[(3-methoxybenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C22H29N2O3+
|
1
|
| 1 |
IC50 = 9550 nM
|
|
|
|
CP0449022
|
2-[4-[(3,4-dichlorobenzoyl)amino]phenyl]ethyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C22H27Cl2N2O2+
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0449023
|
[4-[(2,3-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25Cl2N2O2+
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0457554
|
[4-[(2-chlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H26ClN2O2+
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0433282
|
N-[3-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-3-oxopropyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H23ClF3N3O2
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0382116
|
2-chloro-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H21Cl2N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0382120
|
2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H23ClN4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0382122
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H22ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0404937
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-cyanobenzamide
Show/Hide
|
C21H21ClN4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0427841
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-2-methylbenzamide
Show/Hide
|
C21H24ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0485900
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-2-(trifluoromethyl)benzamide
Show/Hide
|
C21H21ClF3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0516056
|
3-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H23ClN4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0525688
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-methoxybenzamide
Show/Hide
|
C21H24ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0525711
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-4-methylbenzamide
Show/Hide
|
C21H24ClN3O2
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0378465
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophenyl)guanidine
Show/Hide
|
C15H12ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0409868
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-phenylphenyl)urea
Show/Hide
|
C21H16N2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0469118
|
1-(Benzo[d][1,3]dioxol-5-yl)-3-(3-chlorobenzoyl)urea
Show/Hide
|
C15H11ClN2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0501420
|
5-(Benzo[d][1,3]dioxol-5-yl)-N-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-amine
Show/Hide
|
C15H9Cl2N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0516891
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophenyl)-1-methylurea
Show/Hide
|
C16H13ClN2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0518581
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophenyl)-1,3-dimethylurea
Show/Hide
|
C17H15ClN2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0530014
|
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(4-phenylphenyl)urea
Show/Hide
|
C21H16N2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0468487
|
N-[1-(4-ethynylcyclohexyl)azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
Show/Hide
|
C22H26F3N5O
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0290748
|
N-(2-chlorophenyl)-4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]piperazine-1-carboxamide
Show/Hide
|
C20H29ClN4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0509743
|
4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-(3-methylsulfonylphenyl)piperazine-1-carboxamide
Show/Hide
|
C21H32N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0404730
|
1-(3,3-Diphenyl-propyl)-4-pyridin-4-ylmethyl-[1,4]diazepane
Show/Hide
|
C26H31N3
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0501205
|
1,1-Bis-(4-chloro-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propan-1-ol
Show/Hide
|
C28H32Cl2N2O3S
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0464116
|
(E)-3-(3,4-dichlorophenyl)-1-(4-((4-(2-methoxyphenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C27H32Cl2N2O2
|
1
|
| 1 |
IC50 = 11100 nM
|
|
|
|
CP0382266
|
[3-[(3,4-dichlorobenzoyl)amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium
Show/Hide
|
C21H25Cl2N2O2+
|
1
|
| 1 |
IC50 = 11350 nM
|
|
|
|
CP0496889
|
1-(3-Fluoro-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-propan-1-ol
Show/Hide
|
C28H33FN2O3S
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0457731
|
(E)-3-(3,5-difluorophenyl)-N-((1R,3S)-3-((4-(4-methoxyphenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide
Show/Hide
|
C27H32F2N2O2
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0490396
|
(E)-3-(3,4-dichlorophenyl)-N-(5-(4-(4-hydroxyphenyl)piperidin-1-yl)pentyl)acrylamide
Show/Hide
|
C25H30Cl2N2O2
|
1
|
| 1 |
IC50 = 12600 nM
|
|
|
|
CP0496850
|
1-(3,3-Diphenyl-propyl)-4-(4-methanesulfonyl-benzyl)-[1,4]diazepane
Show/Hide
|
C28H34N2O2S
|
1
|
| 1 |
IC50 = 13000 nM
|
|
|
|
CP0379321
|
3-[4-(4-Methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-1-phenyl-1-m-tolyl-propan-1-ol
Show/Hide
|
C29H36N2O3S
|
1
|
| 1 |
IC50 = 16000 nM
|
|
|
|
CP0487156
|
[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-1-methylsulfonyl-2,3,4,5,6,6a-hexahydrocyclopenta[b]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C24H33F3N4O5S
|
1
|
| 1 |
IC50 = 16100 nM
|
|
|
|
CP0497591
|
1-(3,3-Diphenyl-propyl)-4-(4-nitro-benzyl)-[1,4]diazepane
Show/Hide
|
C27H31N3O2
|
1
|
| 1 |
IC50 = 19000 nM
|
|
|
|
CP0087964
|
N-[(2R)-1-[4-(4-chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamide
Show/Hide
|
C23H27ClN2O2
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0411741
|
[(3aS,5S,6aR)-5-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[5-[2-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
Show/Hide
|
C24H32F3N5O4
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0440602
|
[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-1,1-dioxo-2,3,4,5,6,6a-hexahydrocyclopenta[b]thiophen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Show/Hide
|
C23H30F3N3O5S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0487155
|
1-[(3aR,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,4,5,6,6a-hexahydrocyclopenta[b]pyrrol-1-yl]ethanone
Show/Hide
|
C25H33F3N4O4
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0513265
|
[(3aS,5S,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[5-[6-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
Show/Hide
|
C24H32F3N5O4
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0379190
|
1,1-di(4-hydroxyphenyl)-3-[4-(4-methylsulfonylbenzyl)-1,4-diazepan-1-yl]-1-propanol
Show/Hide
|
C28H34N2O5S
|
1
|
| 1 |
IC50 = 21000 nM
|
|
|
|
CP0516053
|
N-[1-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-1-oxopropan-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H23ClF3N3O2
|
1
|
| 1 |
IC50 = 22000 nM
|
|
|
|
CP0389105
|
N-[2-[[1-(4-cyano-4-phenylcyclohexyl)azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H27F3N4O2
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0452305
|
N-[2-[[1-[4-(2,6-dimethylphenyl)-4-hydroxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H32F3N3O3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0452312
|
N-[2-[[1-[4-(hydroxymethyl)-4-phenylcyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C26H30F3N3O3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0476336
|
N-[2-[[1-[1-(1,3-benzodioxol-5-yl)piperidin-4-yl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H27F3N4O4
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0505867
|
1-phenyl-4-[3-[[2-[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylic acid
Show/Hide
|
C26H28F3N3O4
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0426019
|
N-[1-(4-aminocyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Show/Hide
|
C19H25F3N6O
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0432862
|
N'-[2-[4-[3-hydroxy-3-(3-hydroxyphenyl)-3-phenylpropyl]-1,4-diazepan-1-yl]acetyl]thiophene-2-carbohydrazide
Show/Hide
|
C27H32N4O4S
|
1
|
| 1 |
IC50 = 28000 nM
|
|
|
|
CP0548898
|
N'-[2-[4-[(4-chlorophenyl)methyl]-1,4-diazepan-1-yl]acetyl]thiophene-2-carbohydrazide
Show/Hide
|
C19H23ClN4O2S
|
1
|
| 1 |
IC50 = 30000 nM
|
|
|
|
CP0480345
|
1,1-Bis-(3-fluoro-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propan-1-ol
Show/Hide
|
C28H32F2N2O3S
|
1
|
| 1 |
IC50 = 34000 nM
|
|
|
|
CP0469543
|
4-[4-(3,3-Diphenyl-propyl)-[1,4]diazepan-1-ylmethyl]-benzonitrile
Show/Hide
|
C28H31N3
|
1
|
| 1 |
IC50 = 43000 nM
|
|
|
|
CP0480350
|
1,1-Bis-(4-dimethylamino-phenyl)-3-[4-(4-methanesulfonyl-benzyl)-[1,4]diazepan-1-yl]-propan-1-ol
Show/Hide
|
C32H44N4O3S
|
1
|
| 1 |
IC50 = 45000 nM
|
|
|
|
CP0485503
|
1-(4-Chloro-benzyl)-4-(4-methanesulfonyl-benzyl)-[1,4]diazepane
Show/Hide
|
C20H25ClN2O2S
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0039052
|
(R)-N-(2-(1-(2-(4-(2-fluorobenzoyl)piperazin-1-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H31F4N5O3
|
1
|
| 1 |
IC50 > 100 nM
|
|
|
|
CP0039053
|
(R)-N-(2-(1-(2-(1-(2-fluorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H32F4N4O3
|
1
|
| 1 |
IC50 > 100 nM
|
|
|
|
CP0095364
|
(R)-N-(2-(1-(2-(1-(2,5-difluorobenzoyl)piperidin-4-yl)ethyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Show/Hide
|
C28H31F5N4O3
|
1
|
| 1 |
IC50 > 100 nM
|
|
|
|
CP0496108
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H40F3N3O4S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0513962
|
N-[(3S)-1-[(1S,2R,4R)-2-(benzenesulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxoazepan-3-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C31H40F3N3O4S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0466518
|
N-[2-[[1-[4-(1H-indol-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H29F3N4O2
|
1
|
| 1 |
IC50 < 1000 nM
|
|
|
|
CP0382121
|
4-chloro-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]benzamide
Show/Hide
|
C20H21Cl2N3O2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0404938
|
N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C21H21ClF3N3O2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0525709
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N-[2-[[(3R)-1-[(3-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
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C21H21ClF3N3O2
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1
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| 1 |
IC50 > 5000 nM
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CP0506133
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2-[2-[(4-chlorophenyl)sulfonylamino]-6-fluoro-4-(trifluoromethyl)phenoxy]benzoic acid
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C20H12ClF4NO5S
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2
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| 1 |
Ki = 63.1 nM
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| 2 |
Ki = 12589.25 nM
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CP0387734
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]-6-fluorobenzoic acid
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C20H12ClF4NO5S
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2
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| 1 |
Ki = 158.49 nM
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| 2 |
Ki = 10000 nM
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CP0416380
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2-[2-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid
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C19H14ClNO5S
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1
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| 1 |
Ki = 398.11 nM
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