Brief Information of the Compound and Protein
Compound Name
3-[[2-oxo-2-[[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]amino]ethyl]amino]-5-(trifluoromethyl)indazole-1-carboxamide
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Canonical SMILES
NC(=O)n1nc(NCC(=O)NC2CN(C2)[C@H]2CC[C@H](CC2)c2nccs2)c2cc(ccc12)C(F)(F)F
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Compound Formula C23H26F3N7O2S
Compound Structure
Protein Name
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  2
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
2
IC50 = 29 nM
   TI
   LI
   LO
   TS