Brief Information of the Compound and Protein
Compound Name
 Compound Info 
[(3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-phenyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
    Show/Hide
 PubChem ID
CID: 76314242
Canonical SMILES
COC1COCCC1N[C@@H]1C[C@H]2CN(C[C@]2(C1)C(=O)N1CCc2ncc(cc2C1)C(F)(F)F)c1ccccc1
    Show/Hide
Compound Formula C29H35F3N4O3
Compound Structure
Protein Name
 Protein Info 
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 62 nM