Brief Information of the Compound and Protein
Compound Name
2-amino-N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
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PubChem ID
CID: 44453472
Canonical SMILES
Nc1ccc(cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1)C(F)(F)F
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Compound Formula C21H22ClF3N4O2
Compound Structure
Protein Name
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Chemokine receptor
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CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CL000040 THP-1 Homo sapiens (Human)  3
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 23.1 nM
   TI
   LI
   LO
   TS
3
IC50 = 26 nM
   TI
   LI
   LO
   TS