Brief Information of the Compound and Protein
Compound Name
ethyl 4-[3-[[2-[[3-benzyl-6-(trifluoromethyl)-2,3-dihydroisoindol-1-ylidene]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxylate
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Canonical SMILES
CCOC(=O)[C@@H]1CC[C@@H](CC1)N1CC(C1)NC(=O)CN=C1NC(Cc2ccccc2)c2ccc(cc12)C(F)(F)F
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Compound Formula C30H35F3N4O3
Compound Structure
Protein Name
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
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Chemokine receptor
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CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  2
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
2
IC50 = 170 nM
   TI
   LI
   LO
   TS