Brief Information of the Compound and Protein
Compound Name
2-amino-N-[2-[[(3R)-1-[(4-hydroxy-3-methoxyphenyl)methyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
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PubChem ID
CID: 508877
Canonical SMILES
COc1cc(CN2CC[C@H](C2)NC(=O)CNC(=O)c2cc(ccc2N)C(F)(F)F)ccc1O
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Compound Formula C22H25F3N4O4
Compound Structure
Protein Name
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
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CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 39 nM
   TI
   LI
   LO
   TS