Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide

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PubChem ID

CID: 10436045

SID: 15455848

Canonical SMILES	Oc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)\C=C\c4ccc(Cl)c(Cl)c4)CC3)c2c1 Show/Hide
Compound Formula	C27H31Cl2N3O2

Compound Structure

Protein Name

Protein Info

C-C chemokine receptor type 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Chemokine receptor

CC chemokine receptor

Uniprot ID

P41597

Gene Name

CCR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 50 nM	TI LI LO TS
2	Ki = 50.12 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	11
1	Ki = 16.6 nM	TI LI LO TS
2	Ki = 100 nM	TI LI LO TS
3	Ki = 128.82 nM	TI LI LO TS
4	Ki = 165.96 nM	TI LI LO TS
5	Ki = 169.82 nM	TI LI LO TS
6	Ki = 229.09 nM	TI LI LO TS
7	Ki = 562.34 nM	TI LI LO TS
8	Ki = 724.44 nM	TI LI LO TS
9	Ki = 2089.3 nM	TI LI LO TS
10	Ki = 2454.71 nM	TI LI LO TS
11	Ki = 2511.89 nM	TI LI LO TS

Biochemical Assays

1	Ki = 50 nM