General Information of the Protein
Protein ID
PT01850
Protein Name
Myeloblastin
Secondarily
Protein Name
AGP7
C-ANCA antigen
Leukocyte proteinase 3
Neutrophil proteinase 4
P29
Wegener autoantigen
Gene Name
PRTN3
Secondarily
Gene Name
MBN
Sequence
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
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Uniprot ID
Primary ID:
P24158

Secondarily ID:
P15637
P18078
Q4VB08
Q4VB09
Q6LBM7
Q6LBN2
Q9UD25
Q9UQD8
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Ensembl ID
ENSG00000196415
HGNC ID
HGNC:9495
Subcellular Location
Cytoplasmic granule
Secreted
Cell membrane
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000100 , U-937
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0064686
 Compound Info 
2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-propyl]-acetamide
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C12H13IN4O2
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0700060
 Compound Info 
(S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1-oxo-3-(thiophen-2-yl)propan-2-aminium 2,2,2-trifluoroacetate
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C19H18F3N3O3S
  1
1
IC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Leukocyte proteinase-3 (PRTN3) )
Target Type Clinical trial Target