| Compound ID |
Compound Name |
Compound Formula |
|
CP0074148
|
5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C22H24Cl2N2O5
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
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CP0458529
|
5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C22H21Cl2N3O4
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
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CP0519444
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1R)-2-hydroxy-1-[(3R)-oxolan-3-yl]ethyl]-3,4-dihydroisoquinolin-1-one
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|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0256275
|
5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C22H21Cl2N3O3
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
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CP0571875
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1R)-2-hydroxy-1-[(2R)-oxolan-2-yl]ethyl]-3,4-dihydroisoquinolin-1-one
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|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0458531
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1R)-2-hydroxy-1-[(2S)-oxolan-2-yl]ethyl]-3,4-dihydroisoquinolin-1-one
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|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0477634
|
5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(S)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C22H24Cl2N2O5
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0567145
|
5,8-dichloro-7-[(R)-hydroxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C21H22Cl2N2O5
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0376800
|
8-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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|
C22H22ClN3O3
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0458533
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(2S)-1-hydroxypropan-2-yl]-3,4-dihydroisoquinolin-1-one
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|
C20H22Cl2N2O3
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0518270
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one
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|
C21H22Cl2N2O4
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0445799
|
8-chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-methyl-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one
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|
C22H25ClN2O4
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0443272
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(3,5-dimethyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one
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|
C22H22Cl2N4O2
|
1
|
| 1 |
IC50 = 502 nM
|
|
|
|
CP0518272
|
8-chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one
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|
C21H23ClN2O4
|
1
|
| 1 |
IC50 = 796 nM
|
|
|
|
CP0420621
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(5-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one
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|
C21H20Cl2N4O2
|
1
|
| 1 |
IC50 = 873 nM
|
|
|
|
CP0398344
|
8-chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-fluoro-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one
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|
C21H22ClFN2O4
|
1
|
| 1 |
IC50 = 994 nM
|
|
|
|
CP0558298
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1S)-2-hydroxy-1-[(2R)-oxolan-2-yl]ethyl]-3,4-dihydroisoquinolin-1-one
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|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 1024 nM
|
|
|
|
CP0458532
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(2R)-1-hydroxypropan-2-yl]-3,4-dihydroisoquinolin-1-one
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|
C20H22Cl2N2O3
|
1
|
| 1 |
IC50 = 1040 nM
|
|
|
|
CP0469580
|
8-chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-propan-2-yloxy-3,4-dihydroisoquinolin-1-one
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|
C20H23ClN2O3
|
1
|
| 1 |
IC50 = 1187 nM
|
|
|
|
CP0534740
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1S)-2-hydroxy-1-[(2S)-oxolan-2-yl]ethyl]-3,4-dihydroisoquinolin-1-one
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|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 1572 nM
|
|
|
|
CP0443271
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1-one
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|
C20H18Cl2N4O2
|
1
|
| 1 |
IC50 = 1726 nM
|
|
|
|
CP0534741
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(1S)-2-hydroxy-1-[(3S)-oxolan-3-yl]ethyl]-3,4-dihydroisoquinolin-1-one
Show/Hide
|
C23H26Cl2N2O4
|
1
|
| 1 |
IC50 = 2911 nM
|
|
|
|
CP0398343
|
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(1,3,5-trimethylpyrazol-4-yl)-3,4-dihydroisoquinolin-1-one
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|
C23H24Cl2N4O2
|
1
|
| 1 |
IC50 = 15308 nM
|
|
|
|
CP0560317
|
5,8-dichloro-7-[(S)-hydroxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
Show/Hide
|
C21H22Cl2N2O5
|
1
|
| 1 |
IC50 > 32000 nM
|
|
|
