General Information of the Compound
Compound ID
CP0560317
Compound Name
5,8-dichloro-7-[(S)-hydroxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
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Structure
Formula
C21H22Cl2N2O5
Molecular Weight
453.322
Canonical SMILES
COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@@H](O)C3COC3)c(Cl)c2C1=O
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InChI
InChI=1S/C21H22Cl2N2O5/c1-10-5-16(29-2)14(20(27)24-10)7-25-4-3-12-15(22)6-13(18(23)17(12)21(25)28)19(26)11-8-30-9-11/h5-6,11,19,26H,3-4,7-9H2,1-2H3,(H,24,27)/t19-/m0/s1
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InChIKey
HOFBNXGXIBQPDO-IBGZPJMESA-N
Physicochemical Property
logP
2.87702
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
91.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137650028
ChEMBL ID
CHEMBL4077607
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03003, Histone-lysine N-methyltransferase EZH2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000180 Karpas-422 Homo sapiens (Human)  1
1
IC50 > 32000 nM
   TI
   LI
   LO
   TS