Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5,8-dichloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(3R)-oxolan-3-yl]oxy-3,4-dihydroisoquinolin-1-one
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 PubChem ID
CID: 90233931
Canonical SMILES
Cc1cc(C)c(CN2CCc3c(Cl)cc(O[C@@H]4CCOC4)c(Cl)c3C2=O)c(=O)[nH]1
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Compound Formula C21H22Cl2N2O4
Compound Structure
Protein Name
 Protein Info 
Histone-lysine N-methyltransferase EZH2
Protein Classification
Epigenetic regulator
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Protein methyltransferase
Uniprot ID
Q15910
Gene Name
EZH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000180 Karpas-422
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 18 nM
   TI
   LI
   LO
   TS