| Compound ID |
Compound Name |
Compound Formula |
|
CP0763406
|
4-Amino-6-(((1S)-1-(6-fluoro-3-phenyl-4-(1-piperazinylcarbonyl)-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C27H25FN8O
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0376487
|
2-methyl-1-[4-[2-[2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]propan-2-ol
Show/Hide
|
C22H21F3N6O2S
|
1
|
| 1 |
IC50 < 0.5 nM
|
|
|
|
CP0380703
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-(1H-pyrazol-4-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H18N6OS
|
1
|
| 1 |
IC50 < 0.5 nM
|
|
|
|
CP0380704
|
8-(azetidin-3-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H21N5OS
|
1
|
| 1 |
IC50 < 0.5 nM
|
|
|
|
CP0375072
|
8-(1-methylimidazol-4-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H20N6OS
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0705621
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N,N-dimethyl-3-phenyl-4-quinolinecarboxamide
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|
C25H22FN7O
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0468673
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-pyrrolidin-3-yl-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0735509
|
4-Amino-6-(((1S)-1-(4-((1,1-dioxido-4-thiomorpholinyl)carbonyl)-6-fluoro-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C27H24FN7O3S
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0376489
|
8-piperidin-4-yl-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C21H25N5OS
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0720960
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C24H20FN7O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0735510
|
4-Amino-6-(((1S)-1-(6-fluoro-4-((3-hydroxy-1-azetidinyl)-carbonyl)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C26H22FN7O2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0404178
|
5-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyridin-2-amine
Show/Hide
|
C21H20N6OS
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0379787
|
2-[2-[4-[(4-methylpiperazin-1-yl)methyl]-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C24H32N6O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0740357
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C23H18FN7O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0375073
|
8-(1H-imidazol-2-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H18N6OS
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0053343
|
4-amino-6-[[(1S)-1-(6-fluoro-3,4-dipyridin-2-ylquinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C26H19FN8
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0830605
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C23H19FN8O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0007893
|
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
Show/Hide
|
C23H27N7O3S2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 31 nM
|
|
|
|
CP0698893
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-(1-methylethyl)-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C26H24FN7O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0380434
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-pyrrolidin-2-yl-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0404180
|
[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methanol
Show/Hide
|
C17H18N4O2S
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0456044
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C16H16N4OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0698894
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-ethyl-6-fluoro-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C24H21FN8O
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0333717
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide
Show/Hide
|
C18H18N4O2S
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0252844
|
N-[2-chloro-5-(4-morpholin-4-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C24H20ClFN4O3S
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0776506
|
Rac-4-Amino-6-(1-(6-fluoro-4-(piperazine-1-carbonyl)-3-(pyridin-2-yl)quinolin-2-yl)ethylamino)pyrimidine-5-carbonitrile
Show/Hide
|
C26H24FN9O
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0090561
|
N-[2-chloro-5-(3-morpholin-4-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C23H19ClFN5O3S
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0735511
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C23H19FN8O
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0720957
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-(2-(dimethylamino)ethyl)-6-fluoro-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C25H24FN9O
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0298054
|
N-[2-chloro-5-[3-(4-propan-2-ylpiperazin-1-yl)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C26H26ClFN6O2S
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0210324
|
N-[2-chloro-5-(4-pyridin-3-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H16ClFN4O2S
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0090562
|
N-[2-chloro-5-[4-[4-(pyridin-4-ylmethyl)piperazin-1-yl]quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C30H26ClFN6O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0152367
|
N-[2-chloro-5-(4-pyridin-4-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H16ClFN4O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0252843
|
N-[2-chloro-5-[3-(2-morpholin-4-ylethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H24ClFN6O3S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0704953
|
2-{2-[(2R)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)-pyrimidin-4(3H)-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0338973
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-3-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0376488
|
3-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]-1H-pyridin-2-one
Show/Hide
|
C21H19N5O2S
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0380436
|
1-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]ethane-1,2-diol
Show/Hide
|
C18H20N4O3S
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0380449
|
2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methylamino]ethanol
Show/Hide
|
C19H23N5O2S
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0776505
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-(2-(methylamino)ethyl)-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C26H25FN8O
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0409919
|
N-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methyl]acetamide
Show/Hide
|
C19H21N5O2S
|
1
|
| 1 |
IC50 = 10.2 nM
|
|
|
|
CP0830604
|
Rac-4-Amino-6-(1-(6-fluoro-4-(3-hydroxyazetidine-1-carbonyl)-3-(pyridin-2-yl)quinolin-2-yl)ethylamino)pyrimidine-5-carbonitrile
Show/Hide
|
C25H21FN8O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0155508
|
2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0134137
|
4-morpholin-4-yl-2-[2-oxo-2-(4-phenyl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0720958
|
AMG319
Show/Hide
|
C21H16FN7
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0204633
|
2-[(1-cyclohexylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C22H27N5O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0134138
|
2-[2-(4-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0147576
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-4-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0402567
|
2-[2-[4-(4-methylpiperazin-1-yl)-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H30N6O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0431538
|
2-[2-(4-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0180687
|
2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0865509
|
4-Methyl-N-[2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]benzamide
Show/Hide
|
C20H20N4O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0308575
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethoxy)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0188427
|
4-morpholin-4-yl-2-[(1-phenylbenzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0322768
|
2-[(1-cyclopropyl-5-fluorobenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H20FN5O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0450213
|
2-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0533679
|
5-[2-amino-4-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C18H12ClF5N4O3S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0725929
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-ethyl-6-fluoro-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C25H22FN7O
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0426527
|
2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19BrN4O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0147436
|
2-[(1-benzylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0308574
|
2-[2-(3-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0308576
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethyl)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O3
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0456950
|
3-amino-6-[4-chloro-3-[(3-chlorophenyl)sulfonylamino]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0347349
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-2-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0186648
|
2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)-N-phenylacetamide
Show/Hide
|
C16H18N4O3
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0362492
|
BDBM50447090
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0003061
|
9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
|
C21H24N4O2
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 851 nM
|
|
|
|
CP0688695
|
7-methyl-9-(2-methylbenzylamino)-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
|
C21H24N4O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0891905
|
N-(4-Methylphenyl)-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
|
C20H20N4O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0877287
|
2-(4-Morpholinyl)-4-oxo-N-phenyl-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
|
C19H18N4O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0248363
|
2-[(5-fluoro-4-phenyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C22H19FN4O3
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0439702
|
8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
Show/Hide
|
C20H19FN2O3
|
1
|
| 1 |
IC50 = 166 nM
|
|
|
|
CP0253245
|
4-morpholin-4-yl-2-[(4-phenyl-1H-benzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
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C22H21N5O2
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1
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| 1 |
IC50 = 180 nM
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CP0169945
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2-[(1-methyl-7-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C23H23N5O2
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1
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| 1 |
IC50 = 181 nM
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CP0455221
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5-(2-amino-4-methoxypyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
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C17H13ClF2N4O3S
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1
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| 1 |
IC50 = 181 nM
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CP0891904
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7-Methyl-9-[(3-methylbenzyl)amino]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C21H24N4O2
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1
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| 1 |
IC50 = 200 nM
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CP0322769
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2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C16H16FN5O2
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1
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| 1 |
IC50 = 219 nM
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CP0849182
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(Rac)-7-Methyl-9-[1-(methylanilino)ethyl]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C22H26N4O2
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1
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| 1 |
IC50 = 220 nM
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CP0852664
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N-[2-(4-Morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]benzamide
Show/Hide
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C19H18N4O3
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1
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| 1 |
IC50 = 220 nM
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CP0362462
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2-[(1-ethylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C18H21N5O2
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1
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| 1 |
IC50 = 225 nM
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CP0848714
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9-(Benzylamino)-7-methyl-2-(4-morpholinyl)-4H-pyrido-[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 230 nM
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CP0380836
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9-[(4-methoxyanilino)methyl]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O3
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1
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| 1 |
IC50 = 240 nM
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CP0298910
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2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C16H16ClN5O2
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1
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| 1 |
IC50 = 247 nM
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CP0295159
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2-[[5-fluoro-1-(2-methoxyethyl)benzimidazol-2-yl]methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C19H22FN5O3
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1
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| 1 |
IC50 = 270 nM
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CP0852663
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9-[(Methylanilino)methyl]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 270 nM
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CP0885989
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2-Methyl-N-[2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]benzamide
Show/Hide
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C20H20N4O3
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1
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| 1 |
IC50 = 270 nM
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CP0889366
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7-Methyl-2-(4-morpholinyl)-9-{[(1S)-1-phenylethyl]amino}-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C21H24N4O2
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1
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| 1 |
IC50 = 270 nM
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CP0262695
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2-[(1-methyl-4-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C23H23N5O2
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1
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| 1 |
IC50 = 274 nM
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CP0134136
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BDBM50447097
Show/Hide
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C20H24N4O3
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1
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| 1 |
IC50 = 278 nM
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CP0176436
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2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
Show/Hide
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C19H22N4O3
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1
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| 1 |
IC50 = 278 nM
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CP0849180
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N-(3-Methylphenyl)-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
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C20H20N4O3
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1
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| 1 |
IC50 = 300 nM
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CP0848713
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7-Methyl-2-(4-morpholinyl)-9-(2-methylphenyl)-4Hpyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 310 nM
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CP0869038
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5-Phenyl-3-(1'-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
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C21H25N5O2S
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1
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| 1 |
IC50 = 320 nM
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CP0322764
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4-morpholin-4-yl-2-[(4-pyridin-3-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
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C21H19N5O3
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1
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| 1 |
IC50 = 335 nM
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CP0456951
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3-amino-6-[4-chloro-3-[(2-chloro-4-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H14Cl2FN5O3S
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1
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| 1 |
IC50 = 340 nM
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CP0455223
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3-amino-6-[4-chloro-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H16ClN5O3S
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1
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| 1 |
IC50 = 352 nM
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CP0169944
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4-morpholin-4-yl-2-[(4-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
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C22H20N4O3
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1
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| 1 |
IC50 = 373 nM
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CP0453880
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5-[3-[4-[3-(4-methoxyphenyl)pyrazin-2-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
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C25H25N7O3S
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1
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| 1 |
IC50 = 387 nM
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CP0248389
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2-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C17H19N5O3
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1
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| 1 |
IC50 = 397 nM
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CP0169941
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4-morpholin-4-yl-2-[(4-thiophen-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
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C20H18N4O3S
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1
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| 1 |
IC50 = 398 nM
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CP0866918
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9-Anilino-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-a]-pyrimidin-4-one
Show/Hide
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C19H20N4O2
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1
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| 1 |
IC50 = 410 nM
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CP0020253
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3-amino-6-[4-chloro-3-[(3-fluoro-2-methylphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C19H17ClFN5O3S
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1
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| 1 |
IC50 = 415 nM
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CP0456942
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3-amino-6-[4-chloro-3-[(3-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H15ClFN5O3S
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1
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| 1 |
IC50 = 415 nM
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CP0433674
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3-amino-6-[4-chloro-3-[(3-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H15Cl2N5O3S
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1
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| 1 |
IC50 = 437 nM
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CP0169946
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2-[(6-bromo-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C16H16BrN5O2
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1
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| 1 |
IC50 = 442 nM
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CP0908315
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7-Methyl-2-(4-morpholinyl)-9-[(3-pyridinylmethyl)amino]-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C19H21N5O2
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1
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| 1 |
IC50 = 450 nM
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CP0481681
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5-[3-[4-[2-(4-propan-2-ylphenyl)pyridin-3-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
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C28H30N6O2S
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1
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| 1 |
IC50 = 456 nM
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CP0852658
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9-[(4-Methoxyphenoxy)methyl]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H21N3O4
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1
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| 1 |
IC50 = 460 nM
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CP0698887
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2-{2-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one
Show/Hide
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C19H22N4O3
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1
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| 1 |
IC50 = 468 nM
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CP0859323
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9-(Anilinomethyl)-2-(4-morpholinyl)-4H-pyrido[1,2-a]-pyrimidin-4-one
Show/Hide
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C19H20N4O2
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1
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| 1 |
IC50 = 470 nM
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CP0865510
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2-(4-Morpholinyl)-9-(phenoxymethyl)-4H-pyrido[1,2-a]-pyrimidin-4-one
Show/Hide
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C19H19N3O3
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1
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| 1 |
IC50 = 470 nM
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CP0877285
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3-Methyl-N-[2-(4-Morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]benzamide
Show/Hide
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C20H20N4O3
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1
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| 1 |
IC50 = 470 nM
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CP0889364
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2-(4-Morpholinyl)-9-(2-toluidinomethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 470 nM
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CP0908317
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7-Methyl-2-(4-morpholinyl)-9-(3-methylphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 470 nM
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CP0859324
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N-[2-(4-Morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]-N'-phenylurea
Show/Hide
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C19H19N5O3
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1
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| 1 |
IC50 = 480 nM
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CP0852660
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9-(2,6-Dimethylanilino)-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C21H24N4O2
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1
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| 1 |
IC50 = 500 nM
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CP0859065
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N-(2-Methylphenyl)-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
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C20H20N4O3
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1
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| 1 |
IC50 = 530 nM
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CP0433670
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3-amino-6-[6-amino-5-(phenylsulfamoyl)pyridin-3-yl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C17H17N7O3S
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1
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| 1 |
IC50 = 533 nM
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CP0413763
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3-amino-6-[4-chloro-3-[(4-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H15Cl2N5O3S
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1
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| 1 |
IC50 = 539 nM
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CP0413761
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3-amino-6-[4-chloro-3-[(3-methoxyphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C19H18ClN5O4S
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1
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| 1 |
IC50 = 546 nM
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CP0848712
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9-[(4-Methylphenoxy)methyl]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H21N3O3
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1
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| 1 |
IC50 = 550 nM
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CP0413764
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3-amino-6-[4-chloro-3-[(3-methylphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C19H18ClN5O3S
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1
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| 1 |
IC50 = 568 nM
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CP0849236
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2-morpholino-9-(phenylthiomethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C19H19N3O2S
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1
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| 1 |
IC50 = 570 nM
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CP0379786
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2-[2-(2,2-dimethyl-3H-indol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C20H24N4O3
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1
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| 1 |
IC50 = 580 nM
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CP0889365
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4-Methyl-N-{[2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]-pyrimidin-9-yl]methyl}benzenesulfonamide
Show/Hide
|
C20H22N4O4S
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1
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| 1 |
IC50 = 600 nM
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CP0488589
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3-amino-6-(4-chloro-3-sulfamoylphenyl)-N-methylpyrazine-2-carboxamide
Show/Hide
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C12H12ClN5O3S
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1
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| 1 |
IC50 = 638 nM
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CP0910669
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7-Methyl-9-[(4-methylbenzyl)amino]-2-(4-morpholinyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C21H24N4O2
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1
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| 1 |
IC50 = 640 nM
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CP0147577
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2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C19H22N4O4
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1
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| 1 |
IC50 = 648 nM
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CP0084873
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8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one
Show/Hide
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C22H24N2O3
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1
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| 1 |
IC50 = 658 nM
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CP0027760
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3-amino-6-[4-chloro-3-[(2,3-difluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H14ClF2N5O3S
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1
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| 1 |
IC50 = 690 nM
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CP0380835
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9-[(4-methylanilino)methyl]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 710 nM
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CP0891906
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7-Methyl-2-(4-morpholinyl)-9-[(4-pyridinylmethyl)amino]-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C19H21N5O2
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1
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| 1 |
IC50 = 710 nM
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CP0456948
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3-amino-6-[4-chloro-3-[(2,3-dichlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H14Cl3N5O3S
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1
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| 1 |
IC50 = 743 nM
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CP0295019
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2-(1,3-benzoxazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C16H16N4O3
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1
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| 1 |
IC50 = 779 nM
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CP0852661
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7-Methyl-2-(4-morpholinyl)-9-{[(1R)-1-phenylethyl]amino}-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C21H24N4O2
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1
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| 1 |
IC50 = 800 nM
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CP0910670
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7-Methyl-2-(4-morpholinyl)-9-[(2-pyridinylmethyl)amino]-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C19H21N5O2
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1
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| 1 |
IC50 = 800 nM
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CP0448986
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9-[(3-methylanilino)methyl]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 810 nM
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CP0381346
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5-[3-[4-[3-(4-propan-2-ylphenyl)pyrazin-2-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
|
C27H29N7O2S
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1
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| 1 |
IC50 = 816 nM
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CP0204632
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2-[(5-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C16H15FN4O3
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1
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| 1 |
IC50 = 854 nM
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CP0261386
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2-[(5-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C17H18FN5O2
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1
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| 1 |
IC50 = 855 nM
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CP0891722
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5-Ethyl-3-(10-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C17H25N5O2S
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1
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| 1 |
IC50 = 880 nM
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CP0891903
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7-Methyl-9-(methylanilino)-(4-morpholinyl)-4H-pyrido-[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 900 nM
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CP0238398
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4-morpholin-4-yl-2-[(4-pyridin-4-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
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C21H19N5O3
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1
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| 1 |
IC50 = 995 nM
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CP0859322
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7-Methyl-2-(4-morpholinyl)-9-(4-methylphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Show/Hide
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C20H22N4O2
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1
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| 1 |
IC50 = 1000 nM
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CP0413762
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3-amino-6-[4-chloro-3-[(2-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
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1
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| 1 |
IC50 = 1020 nM
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CP0867448
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5-Ethyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C16H23N5O2S
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1
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| 1 |
IC50 = 1020 nM
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CP0381347
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3-amino-6-[4-chloro-3-[(2,4-dichlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl3N5O3S
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1
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| 1 |
IC50 = 1032 nM
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CP0341821
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2-[(6-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C17H18FN5O2
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1
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| 1 |
IC50 = 1060 nM
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CP0525817
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3-amino-6-[4-chloro-3-(methylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C13H14ClN5O3S
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1
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| 1 |
IC50 = 1073 nM
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CP0456949
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3-amino-N-methyl-6-[3-(phenylsulfamoyl)phenyl]pyrazine-2-carboxamide
Show/Hide
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C18H17N5O3S
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1
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| 1 |
IC50 = 1095 nM
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CP0484410
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9-[(4-chloroanilino)methyl]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
|
C19H19ClN4O2
|
1
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| 1 |
IC50 = 1100 nM
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CP0453879
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2-(4-methoxyphenyl)-3-[4-[3-(4-methoxyphenyl)phenyl]sulfonylpiperazin-1-yl]pyrazine
Show/Hide
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C28H28N4O4S
|
1
|
| 1 |
IC50 = 1134 nM
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CP0322765
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2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
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C17H18N4O3
|
1
|
| 1 |
IC50 = 1137 nM
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CP0169943
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4-morpholin-4-yl-2-[(7-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
IC50 = 1181 nM
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CP0484883
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3-amino-6-[4-chloro-3-[(2-chloro-3-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl2FN5O3S
|
1
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| 1 |
IC50 = 1186 nM
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CP0456947
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3-amino-6-[4-methoxy-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C19H19N5O4S
|
1
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| 1 |
IC50 = 1202 nM
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CP0381386
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3-amino-6-[3-[(3-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H16ClN5O3S
|
1
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| 1 |
IC50 = 1253 nM
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CP0453878
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5-(2-aminopyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C16H11ClF2N4O2S
|
1
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| 1 |
IC50 = 1316 nM
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CP0484882
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3-amino-6-[4-chloro-3-[[3-(trifluoromethyl)phenyl]sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H15ClF3N5O3S
|
1
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| 1 |
IC50 = 1355 nM
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CP0111428
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2-[(1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H19N5O2
|
1
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| 1 |
IC50 = 1395 nM
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CP0455222
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3-amino-6-[4-chloro-3-(2,2,2-trifluoroethylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C14H13ClF3N5O3S
|
1
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| 1 |
IC50 = 1418 nM
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CP0852659
|
4-{[2-(4-Morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]methoxy}benzonitrile
Show/Hide
|
C20H18N4O3
|
1
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| 1 |
IC50 = 1500 nM
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CP0456946
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3-amino-6-[4-fluoro-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
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C18H16FN5O3S
|
1
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| 1 |
IC50 = 1582 nM
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CP0849535
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5-Phenyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10a-hexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C20H23N5O2S
|
1
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| 1 |
IC50 = 1680 nM
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CP0852665
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N-[2-(4-Morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]benzenesulfonamide
Show/Hide
|
C18H18N4O4S
|
1
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| 1 |
IC50 = 1700 nM
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CP0852662
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Phenyl 2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-ylcarbamate
Show/Hide
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C19H18N4O4
|
1
|
| 1 |
IC50 = 1800 nM
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CP0864151
|
3-(4-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C24H27N5O2S
|
1
|
| 1 |
IC50 = 1810 nM
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CP0248388
|
4-morpholin-4-yl-2-[(4-pyridin-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C21H19N5O3
|
1
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| 1 |
IC50 = 2170 nM
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CP0341820
|
2-[(6-methyl-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 = 2210 nM
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CP0341818
|
2-[(4-bromo-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15BrN4O3
|
1
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| 1 |
IC50 = 2271 nM
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CP0303999
|
2-[(7-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 = 2385 nM
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CP0453882
|
3-amino-6-[3-[(2,3-difluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15F2N5O3S
|
1
|
| 1 |
IC50 = 2452 nM
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CP0295157
|
2-[(7-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 = 2555 nM
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CP0886055
|
3-(3,4-Dimethoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C25H29N5O3S
|
1
|
| 1 |
IC50 = 2610 nM
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CP0869037
|
3-(3-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C24H27N5O2S
|
1
|
| 1 |
IC50 = 2740 nM
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CP0237639
|
2-[(4-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 = 2755 nM
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CP0341819
|
4-morpholin-4-yl-2-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]-1H-pyrimidin-6-one
Show/Hide
|
C17H16F3N5O2
|
1
|
| 1 |
IC50 = 2850 nM
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CP0362464
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2-(1H-benzimidazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H17N5O2
|
1
|
| 1 |
IC50 = 2870 nM
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|
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CP0413759
|
3-amino-6-[3-[(3-chlorophenyl)sulfonylamino]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H16ClN5O3S
|
1
|
| 1 |
IC50 = 2964 nM
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|
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CP0455220
|
3-amino-6-[3-(benzenesulfonamido)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H17N5O3S
|
1
|
| 1 |
IC50 = 3389 nM
|
|
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CP0210357
|
2-[(1-methyl-6-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 = 3406 nM
|
|
|
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CP0869039
|
3-(3-Hydroxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C23H25N5O2S
|
1
|
| 1 |
IC50 = 3550 nM
|
|
|
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CP0382537
|
8-ethyl-11-(3-hydroxy-4-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile
Show/Hide
|
C24H27N5O3S
|
1
|
| 1 |
IC50 = 3970 nM
|
|
|
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CP0308577
|
2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 4135 nM
|
|
|
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CP0456945
|
3-amino-N-methyl-6-[3-(2H-tetrazol-5-yl)phenyl]pyrazine-2-carboxamide
Show/Hide
|
C13H12N8O
|
1
|
| 1 |
IC50 = 4204 nM
|
|
|
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CP0456944
|
5-(5-aminopyrazin-2-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C16H11ClF2N4O2S
|
1
|
| 1 |
IC50 = 4389 nM
|
|
|
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CP0169947
|
2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
Show/Hide
|
C17H18FN5O2
|
1
|
| 1 |
IC50 = 5715 nM
|
|
|
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CP0210358
|
2-[(1-methyl-5-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 = 6748 nM
|
|
|
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CP0433672
|
3-amino-N-methyl-6-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide
Show/Hide
|
C13H11F3N4O
|
1
|
| 1 |
IC50 = 8359 nM
|
|
|
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CP0322767
|
2-[(4-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 = 8450 nM
|
|
|
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CP0322766
|
2-[(6-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 = 9040 nM
|
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CP0849237
|
2-(4-Morpholinyl)-4-oxo-N-(4-pyridinylmethyl)-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
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CP0889367
|
2-(4-Morpholinyl)-4-oxo-N-(3-pyridinylmethyl)-4H-pyrido[1,2-a]pyrimidine-9-carboxamide
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
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|
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CP0908314
|
2-(4-Morpholinyl)-9-[(phenylsulfonyl)methyl]-4H-pyrido-[1,2-a]pyrimidin-4-one
Show/Hide
|
C19H19N3O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0919779
|
2-(4-Morpholinyl)-4-oxo-N-(2-pyridinylmethyl)-4H-pyrido-[1,2-a]pyrimidine-9-carboxamide
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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CP0865022
|
5-Ethyl-3-(3-methoxyphenyl)-1-morpholino-8,9,10,10a-tetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
Show/Hide
|
C22H27N5O2S
|
1
|
| 1 |
IC50 = 14570 nM
|
|
|
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CP0865020
|
5-Ethyl-3-(4-methoxyphenyl)-1-morpholino-8,9,10,10a-tetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
Show/Hide
|
C22H27N5O2S
|
1
|
| 1 |
IC50 = 20120 nM
|
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CP0865021
|
3-(4-Methoxyphenyl)-1-morpholino-5-phenyl-8,9,10,10atetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
Show/Hide
|
C26H27N5O2S
|
1
|
| 1 |
IC50 = 56890 nM
|
|
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CP0881577
|
3-(3-Methoxyphenyl)-1-morpholino-5-phenyl-8,9,10,10atetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
Show/Hide
|
C26H27N5O2S
|
1
|
| 1 |
IC50 = 71350 nM
|
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CP0085320
|
2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol
Show/Hide
|
C21H22N6O2S
|
1
|
| 1 |
Ki = 0.61 nM
|
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CP0064487
|
N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide
Show/Hide
|
C19H14ClFN6O3S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
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CP0330594
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylphenyl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H23N7O3S
|
1
|
| 1 |
Ki = 1 nM
|
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CP0199338
|
N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H14ClFN4O3S2
|
1
|
| 1 |
Ki = 1.2 nM
|
|
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CP0009370
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O3S
|
1
|
| 1 |
Ki = 2 nM
|
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CP0172054
|
4-[5-(3,6-dihydro-2H-pyran-4-yl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H21N7O2
|
1
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| 1 |
Ki = 2 nM
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CP0087633
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(3-methylsulfonylpyrrolidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H26N8O3S
|
1
|
| 1 |
Ki = 3 nM
|
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CP0191328
|
3-[[1-(4-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]phenol
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
Ki = 3 nM
|
|
|
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CP0335114
|
4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]-N,N-dimethylpiperazine-1-carboxamide
Show/Hide
|
C23H30N10O2
|
1
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| 1 |
Ki = 3 nM
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CP0338291
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28N8O3S
|
1
|
| 1 |
Ki = 3 nM
|
|
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CP0087634
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(1-methylsulfonylpiperidin-4-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28N8O3S
|
1
|
| 1 |
Ki = 4 nM
|
|
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CP0397436
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-morpholin-4-ylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H22N8O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0174686
|
4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]-N,N-dimethylpiperazine-1-sulfonamide
Show/Hide
|
C22H30N10O3S
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0192152
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(1-methylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H19N9O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0452207
|
methyl 4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]piperazine-1-carboxylate
Show/Hide
|
C22H27N9O3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0191321
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(6-methylpyridin-3-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H20N8O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0192153
|
4-[5-methoxy-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C16H17N7O2
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0284307
|
3-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]phenol
Show/Hide
|
C15H14N6O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0191323
|
4-[5-(methoxymethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
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CP0142914
|
2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methyl-1,3,5-triazin-2-ylamino)acetonitrile
Show/Hide
|
C19H16N8O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
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CP0191320
|
4-[5-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24N8O3S
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0282688
|
4-[5-benzyl-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H21N7O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
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CP0391258
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H25N9O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
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CP0192151
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(morpholin-4-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24N8O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0339164
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H26N8O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0172047
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[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methanol
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C16H17N7O2
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1
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| 1 |
Ki = 20 nM
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CP0397437
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4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonyl-1,4-diazepan-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C22H29N9O3S
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1
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| 1 |
Ki = 21 nM
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CP0142948
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N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indol-4-amine
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C17H15N7
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1
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| 1 |
Ki = 25 nM
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CP0192150
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4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperazin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C20H25N9O
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1
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| 1 |
Ki = 27 nM
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CP0191322
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4-[5-[(2-methoxyethylamino)methyl]-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C19H24N8O2
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1
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| 1 |
Ki = 30 nM
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CP0172042
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4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C21H27N9O
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1
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| 1 |
Ki = 34 nM
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CP0349679
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4-[2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H15N7O
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1
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| 1 |
Ki = 37 nM
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CP0369237
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4-[5-chloro-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H14ClN7O
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1
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| 1 |
Ki = 39 nM
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CP0343352
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4-[5-(azetidin-1-ylmethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C19H22N8O
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1
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| 1 |
Ki = 50 nM
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CP0087587
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[(3R)-1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]pyrrolidin-3-yl]methanol
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C21H26N8O2
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1
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| 1 |
Ki = 51 nM
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CP0050326
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2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile
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C18H14N8O
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1
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| 1 |
Ki = 52 nM
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CP0087590
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3-[[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]amino]phenol
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C16H15N5O
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1
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| 1 |
Ki = 56 nM
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CP0313976
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4-[2-[(6-methoxypyridin-3-yl)amino]-5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C20H24N8O
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1
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| 1 |
Ki = 60 nM
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CP0076062
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4-[4-[(6-methoxypyridin-3-yl)amino]pyrimidin-5-yl]-6-methyl-1,3,5-triazin-2-amine
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C14H14N8O
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1
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| 1 |
Ki = 62 nM
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CP0087588
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1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]piperidin-4-ol
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C21H26N8O2
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1
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| 1 |
Ki = 63 nM
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CP0188464
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N-(6-methoxypyridin-3-yl)-3-(2-methyl-7H-purin-6-yl)pyridin-2-amine
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C17H15N7O
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1
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| 1 |
Ki = 70 nM
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CP0292692
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4-[5-bromo-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H14BrN7O
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1
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| 1 |
Ki = 92 nM
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CP0131195
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4-[2-[(6-methoxypyridin-3-yl)amino]-5-methylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C16H17N7O
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1
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| 1 |
Ki = 110 nM
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CP0139562
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6-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-2-methylpyrimidin-4-amine
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C15H15N7O
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1
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| 1 |
Ki = 130 nM
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CP0143583
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N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indazol-4-amine
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C16H14N8
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1
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| 1 |
Ki = 130 nM
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CP0328888
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4-[3-[(6-methoxypyridin-3-yl)amino]pyridin-4-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H15N7O
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1
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| 1 |
Ki = 240 nM
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CP0064828
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4-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-6-methyl-1,3,5-triazin-2-amine
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C14H14N8O
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1
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| 1 |
Ki = 300 nM
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CP0330553
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4-[2-[(6-methoxypyridin-3-yl)amino]phenyl]-6-methyl-1,3,5-triazin-2-amine
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C16H16N6O
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1
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| 1 |
Ki = 310 nM
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CP0282689
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N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine
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C18H14N8
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1
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| 1 |
Ki = 350 nM
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CP0302072
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N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indol-4-amine
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C19H15N7
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1
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| 1 |
Ki = 360 nM
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CP0143584
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N-[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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C17H15N7
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1
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| 1 |
Ki = 370 nM
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CP0346280
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N-[3-(6-amino-5-fluoro-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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C17H14FN7
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1
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| 1 |
Ki = 810 nM
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CP0391261
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4-[3-[(6-methoxypyridin-3-yl)amino]pyridin-2-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H15N7O
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1
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| 1 |
Ki = 910 nM
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CP0191327
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N-[3-(6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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C18H14N8
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1
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| 1 |
Ki = 5000 nM
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CP0229154
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N-(6-methoxypyridin-3-yl)-3-(7H-purin-6-yl)pyridin-2-amine
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C16H13N7O
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1
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| 1 |
Ki = 5700 nM
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CP0335115
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3-[[3-(2-amino-6-methylpyrimidin-4-yl)pyridin-2-yl]amino]phenol
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C16H15N5O
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1
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| 1 |
Ki = 6000 nM
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CP0087589
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N-[3-(7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine
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C17H12N8
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1
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| 1 |
Ki > 10000 nM
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CP0174742
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N-[3-[6-amino-2-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-yl]-1H-indazol-4-amine
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C17H12F3N7
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1
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| 1 |
Ki > 10000 nM
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CP0356738
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4-[2-[(6-methoxypyridin-3-yl)-methylamino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
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C16H17N7O
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1
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| 1 |
Ki > 10000 nM
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CP0356739
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4-[2-(1H-indol-4-yloxy)pyridin-3-yl]-6-methylpyrimidin-2-amine
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C18H15N5O
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1
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| 1 |
Ki > 10000 nM
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