Brief Information of the Compound and Protein
Compound Name
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
    Show/Hide
PubChem ID
CID: 17755052
SID: 29212926
Canonical SMILES
CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
    Show/Hide
Compound Formula C23H27N7O3S2
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
O00329
Gene Name
PIK3CD
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
Ki = 31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 IC50 = 4 nM
3 IC50 = 7 nM
4 IC50 = 9 nM
5 IC50 = 12.59 nM
6 IC50 = 15.7 nM
7 IC50 = 50.12 nM
8 IC50 = 75 nM
9 Kd = 3.3 nM
10 Kd = 5 nM