Brief Information of the Compound and Protein
Compound Name |
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
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PubChem ID | |||||
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Compound Structure |
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Protein Name |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
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Protein Classification |
Enzyme
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Transferase
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Uniprot ID | Gene Name | PIK3CD |
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID | Cell Line Name | Cell Line Organism | |
CL000013 | Sf9 | Spodoptera frugiperda (Fall armyworm) | 2 |
1 |
IC50 = 3 nM
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TI
LI
LO
TS
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2 |
Ki = 31 nM
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TI
LI
LO
TS
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Biochemical Assays
1 | IC50 = 3 nM | ||
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2 | IC50 = 4 nM | ||
3 | IC50 = 7 nM | ||
4 | IC50 = 9 nM | ||
5 | IC50 = 12.59 nM | ||
6 | IC50 = 15.7 nM | ||
7 | IC50 = 50.12 nM | ||
8 | IC50 = 75 nM | ||
9 | Kd = 3.3 nM | ||
10 | Kd = 5 nM |