General Information of the Protein
Protein ID
PT03264
Protein Name
Ubiquitin carboxyl-terminal hydrolase 1
Secondarily
Protein Name
Deubiquitinating enzyme 1
Ubiquitin thioesterase 1
Ubiquitin-specific-processing protease 1
Gene Name
USP1
Sequence
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Cysteine protease
>
Cysteine protease CA clan
>
Cysteine protease C19 family
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
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Uniprot ID
Primary ID:
O94782

Secondarily ID:
A0PJ95
D3DQ57
Q05BX7
Q59H66
Q9UFR0
Q9UNJ3
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Ensembl ID
ENSG00000162607
HGNC ID
HGNC:12607
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0127566
 Compound Info 
3-[[7-[5-chloro-3-methyl-2-[(3S,4R)-3-methylpiperidin-4-yl]oxyphenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione
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C28H30ClN3O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0207779
 Compound Info 
[(2R)-5-chloro-7-[2-(hydroxymethyl)thieno[3,2-b]pyridin-7-yl]-2,3-dihydro-1-benzofuran-2-yl]-piperazin-1-ylmethanone
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C21H20ClN3O3S
  1
1
IC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0339413
 Compound Info 
[(2R)-5-chloro-7-thieno[3,2-b]pyridin-7-yl-2,3-dihydro-1-benzofuran-2-yl]-piperazin-1-ylmethanone
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C20H18ClN3O2S
  1
1
IC50 > 40000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0232610
 Compound Info 
[7-(2-aminopyridin-4-yl)-5-chloro-2,3-dihydro-1-benzofuran-2-yl]-piperazin-1-ylmethanone
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C18H19ClN4O2
  1
1
IC50 > 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0319365
 Compound Info 
3-[[4-hydroxy-1-(2-methyl-3-phenylpropanoyl)piperidin-4-yl]methyl]quinazolin-4-one
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C24H27N3O3
  1
1
IC50 > 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0339425
 Compound Info 
[(2R)-5-chloro-7-(2-methylthieno[3,2-b]pyridin-7-yl)-2,3-dihydro-1-benzofuran-2-yl]-piperazin-1-ylmethanone
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C21H20ClN3O2S
  1
1
IC50 > 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0752437
 Compound Info 
(R)-(5-Chloro-7-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)(piperazin-1-yl)methanone
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C20H19ClN4O2
  1
1
IC50 > 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0808106
 Compound Info 
rac-(5-Chloro-7-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)(piperazin-1-yl)methanone
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C20H19ClN4O2
  1
1
IC50 > 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Deubiquitinating enzyme 1 (USP1) )
Target Type Literature-reported Target
Disease 1 Target-related Disease  1
1 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Preclinical Drug(s) 1 Preclinical Drug  1
1 ML323
 Drug Info 
Preclinical
Solid tumour/cancer