General Information of the Protein
Protein ID
PT00835
Protein Name
Histone deacetylase 2
Secondarily
Protein Name
Protein deacylase HDAC2
Gene Name
HDAC2
Sequence
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
>
Eraser
>
Histone deacetylase
>
HDAC class I
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674).
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Uniprot ID
Primary ID:
Q92769

Secondarily ID:
B3KRS5
B4DL58
E1P561
Q5SRI8
Q5SZ86
Q8NEH4
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Ensembl ID
ENSG00000196591
HGNC ID
HGNC:4853
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
Compound ID Compound Name Compound Formula
CP0444962
5-cyclopropyl-N-[(1S)-1-[4-(hydroxycarbamoyl)phenyl]ethyl]-2-(5-phenyl-1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide
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C25H22N4O3S2
 1
1
IC50 = 13.26 nM
   TI
   LI
   LO
   TS
CP0003580
Faridak
   Show/Hide
C21H23N3O2
 1
1
IC50 = 22.83 nM
   TI
   LI
   LO
   TS
CP0016939
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
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C23H20N6O
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0445497
1-N-(2-amino-5-thiophen-2-ylphenyl)-3-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzene-1,3-dicarboxamide
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C38H35N3O7S
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0389602
N-(2-amino-5-thiophen-2-ylphenyl)-4-[[[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]amino]methyl]benzamide
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C38H37N3O6S
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0445496
4-N-(2-amino-5-thiophen-2-ylphenyl)-1-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzene-1,4-dicarboxamide
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C38H35N3O7S
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0428790
1-N-(2-aminophenyl)-3-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzene-1,3-dicarboxamide
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C34H33N3O7
 1
1
IC50 = 4910 nM
   TI
   LI
   LO
   TS
CP0389603
N-(2-amino-5-thiophen-2-ylphenyl)-3-[[[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]amino]methyl]benzamide
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C38H37N3O6S
 1
1
IC50 = 5410 nM
   TI
   LI
   LO
   TS
CP0387069
N-(2-aminophenyl)-4-[[[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]amino]methyl]benzamide
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C34H35N3O6
 1
1
IC50 = 6730 nM
   TI
   LI
   LO
   TS
CP0387070
4-N-(2-aminophenyl)-1-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]benzene-1,4-dicarboxamide
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C34H33N3O7
 1
1
IC50 = 10420 nM
   TI
   LI
   LO
   TS
CP0389601
N-(2-aminophenyl)-3-[[[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]amino]methyl]benzamide
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C34H35N3O6
 1
1
IC50 > 34383.75711 nM
   TI
   LI
   LO
   TS
CP0037274
(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
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C22H25NO6
 1
1
IC50 > 50070.09814 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0008777
JNJ-26481585
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C21H26N6O2
 5
1 IC50 = 0.33 nM
2 IC50 = 4.26 nM
3 IC50 = 5 nM
4 Ki = 0.06 nM
5 Ki = 31 nM
CP0004955
(5R,8S,11S)-5-methyl-8-propan-2-yl-11-[(E)-4-sulfanylbut-1-enyl]-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione
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C21H28N4O4S3
 2
1 IC50 = 0.9 nM
2 IC50 = 4.19 nM
CP0005479
CHEBI:46024
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C17H22N2O3
 28
1 IC50 = 1 nM
2 IC50 = 1.1 nM
3 IC50 = 4 nM
4 IC50 = 6.08 nM
5 IC50 = 10 nM
6 IC50 = 14 nM
7 IC50 = 14.8 nM
8 IC50 = 15 nM
9 IC50 = 18 nM
10 IC50 = 20.5 nM
11 IC50 = 22.95 nM
12 IC50 = 23 nM
13 IC50 = 23.6 nM
14 IC50 = 24 nM
15 IC50 = 25 nM
16 IC50 = 28.2 nM
17 IC50 = 32.1 nM
18 IC50 = 39 nM
19 IC50 = 39.1 nM
20 IC50 = 46.6 nM
21 IC50 = 52 nM
22 IC50 = 68 nM
23 IC50 = 96 nM
24 IC50 = 7600 nM
25 Ki = 0.65 nM
26 Ki = 0.7 nM
27 Ki = 0.76 nM
28 Ki = 1.06 nM
CP0085832
(1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C24H36N4O6S2
 3
1 IC50 = 1 nM
2 IC50 = 3.9 nM
3 IC50 = 47 nM
CP0004988
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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C21H20N4O3
 21
1 IC50 = 1.2 nM
2 IC50 = 15 nM
3 IC50 = 250 nM
4 IC50 = 340 nM
5 IC50 = 396 nM
6 IC50 = 400 nM
7 IC50 = 410 nM
8 IC50 = 480 nM
9 IC50 = 500 nM
10 IC50 = 505 nM
11 IC50 = 613 nM
12 IC50 = 650 nM
13 IC50 = 720 nM
14 IC50 = 740 nM
15 IC50 = 1000 nM
16 IC50 = 1510 nM
17 IC50 < 300 nM
18 Ki = 6 nM
19 Ki = 65 nM
20 Ki = 73 nM
21 Ki = 590 nM
CP0832315
(S)-6-methyl-N-((S)-1-(5-(2-methyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-1H-imidazol-2-yl)-7-oxononyl)-6-azaspiro[2.5]octane-1-carboxamide
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C31H41N5O3
 1
1 IC50 = 1.6 nM
CP0003832
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
 96
1 IC50 = 1.7 nM
2 IC50 = 10 nM
3 IC50 = 10.2 nM
4 IC50 = 11 nM
5 IC50 = 12 nM
6 IC50 = 13 nM
7 IC50 = 15 nM
8 IC50 = 16 nM
9 IC50 = 17 nM
10 IC50 = 18 nM
11 IC50 = 19 nM
12 IC50 = 21.61 nM
13 IC50 = 24 nM
14 IC50 = 26 nM
15 IC50 = 27 nM
16 IC50 = 28 nM
17 IC50 = 32 nM
18 IC50 = 33 nM
19 IC50 = 35 nM
20 IC50 = 36 nM
21 IC50 = 40 nM
22 IC50 = 52 nM
23 IC50 = 56 nM
24 IC50 = 66 nM
25 IC50 = 72 nM
26 IC50 = 73 nM
27 IC50 = 76 nM
28 IC50 = 82 nM
29 IC50 = 85.8 nM
30 IC50 = 89.23 nM
31 IC50 = 90 nM
32 IC50 = 93.22 nM
33 IC50 = 93.6 nM
34 IC50 = 96 nM
35 IC50 = 98.47 nM
36 IC50 = 100 nM
37 IC50 = 100.9 nM
38 IC50 = 110 nM
39 IC50 = 112.5 nM
40 IC50 = 114 nM
41 IC50 = 118 nM
42 IC50 = 120 nM
43 IC50 = 123.7 nM
44 IC50 = 128.9 nM
45 IC50 = 135 nM
46 IC50 = 137.2 nM
47 IC50 = 140 nM
48 IC50 = 149 nM
49 IC50 = 150 nM
50 IC50 = 153.1 nM
51 IC50 = 154.6 nM
52 IC50 = 156 nM
53 IC50 = 160 nM
54 IC50 = 163.6 nM
55 IC50 = 164 nM
56 IC50 = 167 nM
57 IC50 = 170 nM
58 IC50 = 173 nM
59 IC50 = 174.6 nM
60 IC50 = 176 nM
61 IC50 = 178 nM
62 IC50 = 180 nM
63 IC50 = 182 nM
64 IC50 = 184.7 nM
65 IC50 = 193 nM
66 IC50 = 197 nM
67 IC50 = 200 nM
68 IC50 = 210 nM
69 IC50 = 213 nM
70 IC50 = 220 nM
71 IC50 = 232 nM
72 IC50 = 240 nM
73 IC50 = 250 nM
74 IC50 = 256 nM
75 IC50 = 260 nM
76 IC50 = 280 nM
77 IC50 = 282 nM
78 IC50 = 332.65 nM
79 IC50 = 390 nM
80 IC50 = 400 nM
81 IC50 = 410 nM
82 IC50 = 411 nM
83 IC50 = 454 nM
84 IC50 = 550 nM
85 IC50 = 760 nM
86 IC50 = 780 nM
87 IC50 = 920 nM
88 IC50 = 921 nM
89 IC50 >= 50 nM
90 IC50 > 200 nM
91 Ki = 1.6 nM
92 Ki = 7 nM
93 Ki = 8 nM
94 Ki = 40 nM
95 Ki = 42 nM
96 Ki = 90 nM
CP0826898
(S)-6-methyl-N-((S)-7-oxo-1-(5-(quinolin-3-yl)-1H-imidazol-2-yl)nonyl)-6-azaspiro[2.5]octane-1-carboxamide
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C30H39N5O2
 2
1 IC50 = 2.3 nM
2 IC50 = 4.2 nM
CP0003580
Faridak
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C21H23N3O2
 9
1 IC50 = 3 nM
2 IC50 = 6.8 nM
3 IC50 = 13.2 nM
4 IC50 = 136 nM
5 IC50 < 300 nM
6 Ki = 0.65 nM
7 Ki = 0.7 nM
8 Ki = 1.9 nM
9 Ki = 22 nM
CP0115609
N-hydroxy-2-[2-[6-(6-methoxypyridin-3-yl)-4-methylquinazolin-8-yl]oxyethyl-methylamino]pyrimidine-5-carboxamide
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C23H23N7O4
 1
1 IC50 = 3.4 nM
CP0003676
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
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C23H24N8O4S
 2
1 IC50 = 5 nM
2 IC50 = 8 nM
CP0044706
(2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide
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C22H25N3O3
 3
1 IC50 = 7 nM
2 IC50 = 15.7 nM
3 Ki = 1.4 nM
CP0030986
N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnamamide
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C20H23N3O2
 6
1 IC50 = 14 nM
2 IC50 = 24.8 nM
3 IC50 = 48 nM
4 IC50 = 89.9 nM
5 IC50 = 95.45 nM
6 Ki = 103 nM
CP0013907
US9145412, Table 1, Compound 23
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C24H23N5OS
 1
1 IC50 = 15 nM
CP0637739
(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxononyl)-1-methylazetidine-3-carboxamide
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C27H35N5O3
 1
1 IC50 = 18 nM
CP0004959
S-[(E)-4-[(5R,8S,11S)-5-methyl-6,9,13-trioxo-8-propan-2-yl-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-trien-11-yl]but-3-enyl] octanethioate
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C29H42N4O5S3
 4
1 IC50 = 18.65 nM
2 IC50 = 64 nM
3 IC50 = 900 nM
4 IC50 = 1010 nM
CP0016939
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
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C23H20N6O
 5
1 IC50 = 22 nM
2 IC50 = 280 nM
3 IC50 = 283 nM
4 IC50 = 290 nM
5 Ki = 32.4 nM
CP0363242
US8609678, 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [89]
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C24H26ClN5O3
 1
1 IC50 = 45 nM
CP0004475
RICOLINOSTAT
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C24H27N5O3
 4
1 IC50 = 48 nM
2 IC50 = 95 nM
3 IC50 = 403 nM
4 Ki = 204 nM
CP0034844
HDAC inhibitor, Compound 1
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C19H17N3O2S
 3
1 IC50 = 49 nM
2 IC50 = 100 nM
3 IC50 < 300 nM
CP0013235
(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
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C20H32Cl2N4O2
 2
1 IC50 = 290 nM
2 Ki = 27 nM
CP0010599
UF010
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C11H15BrN2O
 1
1 IC50 = 322 nM
CP0007846
N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
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C20H21N3O2
 9
1 IC50 = 360 nM
2 IC50 = 3575 nM
3 IC50 = 3900 nM
4 IC50 = 6270 nM
5 IC50 = 8674.5 nM
6 IC50 = 19000 nM
7 IC50 > 3000 nM
8 IC50 > 5000 nM
9 IC50 > 30000 nM
CP0446185
[6-[2-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]ethoxy]pyridin-3-yl]methyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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C31H28N6O9S
 1
1 IC50 = 370 nM
CP0013440
4-[(2-bromoacridin-9-yl)amino]-N-hydroxybenzamide
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C20H14BrN3O2
 1
1 IC50 = 480 nM
CP0014809
US10807944, Compound RLS3-43
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C17H20N2O
 1
1 IC50 = 800 nM
CP0086044
(E)-N-hydroxy-3-(4-phenylphenyl)prop-2-enamide
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C15H13NO2
 1
1 IC50 = 820 nM
CP0014908
4-(acetylamino)-N-(2-amino-phenyl) benzamide
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C15H15N3O2
 5
1 IC50 = 900 nM
2 IC50 = 1200 nM
3 IC50 = 1920 nM
4 IC50 = 3850 nM
5 Ki = 190 nM
CP0053451
6-(2-Mercapto-acetylamino)-hexanoic acid quinolin-8-ylamide
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C17H21N3O2S
 1
1 IC50 = 1250 nM
CP0014659
N'-(2-aminophenyl)-N-phenylheptanediamide
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C19H23N3O2
 1
1 IC50 = 1590 nM
CP0014658
US9265734, R01
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C20H25N3O2
 1
1 IC50 = 1980 nM
CP0068281
N-(2-aminophenyl)pyrazine-2-carboxamide
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C11H10N4O
 1
1 IC50 = 2362 nM
CP0053450
6-(3-adamantan-1-yl-ureido)hexanoic acid hydroxyamide
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C17H29N3O3
 1
1 IC50 = 2580 nM
CP0015005
S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate
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C29H42N4O6S2
 1
1 IC50 = 2710 nM
CP0057110
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
 1
1 IC50 = 6920 nM
CP0007404
(E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide
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C21H19FN4O
 2
1 IC50 = 9700 nM
2 IC50 > 15000 nM
CP0528060
tert-butyl (E)-3-hydroxy-7-[[(E)-5-hydroxy-7-[(2-methylpropan-2-yl)oxy]-7-oxohept-3-enyl]disulfanyl]hept-4-enoate
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C22H38O6S2
 2
1 IC50 = 10000 nM
2 IC50 = 100000 nM
CP0053521
5-methyl-3-phenyl-N-[5-[(2-sulfanylacetyl)amino]pentyl]-1,2-oxazole-4-carboxamide
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C18H23N3O3S
 1
1 IC50 = 28000 nM
CP0014148
N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
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C17H16N2O3
 3
1 IC50 > 20000 nM
2 IC50 > 50000 nM
3 IC50 > 100000 nM
CP0008165
N'-(2-aminophenyl)-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide
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C28H30N6O2
 1
1 IC50 > 30000 nM
CP0013905
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
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C24H27N3O4
 1
1 Ki = 3 nM
CP0008445
3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
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C21H23N3O5
 2
1 Ki = 19 nM
2 Ki = 20 nM
Clinical Information about the Protein
Target 1 ( Histone deacetylase 2 (HDAC2) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Investigative Drug(s) 1 Investigative Drug  1
1 ST-2987 Investigative
Solid tumour/cancer
Target 2 ( HUMAN histone deacetylase 2 (HDAC2) )
Target Type Unknown Type Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00991 Histone deacetylase 1 Homo sapiens, Human
PT03901 Histone deacetylase 1 Mus musculus, Mouse