General Information of the Compound
Compound ID
CP0014658
Compound Name
US9265734, R01
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Synonyms
HDAC-1 inhibtors (Friedreich ataxia), RepliGen
RG-2833
RG-FA
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Structure
Formula
C20H25N3O2
Molecular Weight
339.439
Canonical SMILES
Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N
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InChI
InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
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InChIKey
VOPDXHFYDJAYNS-UHFFFAOYSA-N
Physicochemical Property
logP
3.50612
Rotatable Bonds
8
Heavy Atom Count
25
Polar Areas
84.22
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56654642
SID: 134432039
ChEMBL ID
CHEMBL3970532
DrugBank ID
DB16955
Clinical Information about the Compound
Drug 1 ( RG-2833 )
Drug Name RG-2833
Company Repligen
Indication
Friedreich's ataxia
Phase 1
Target(s)
Histone deacetylase 1 (HDAC1)
Modulator