| Compound ID |
Compound Name |
Compound Formula |
|
CP0002393
|
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
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|
C16H20N6O
|
3
|
| 1 |
IC50 = 1.2 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
| 3 |
IC50 = 4.1 nM
|
|
|
|
CP0636232
|
DELGOCITINIB
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|
C16H18N6O
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0012129
|
INCB-018424
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|
C17H18N6
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
IC50 = 4.1 nM
|
|
|
|
CP0029017
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C27H27N7O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0226389
|
4-[2-(cyclopropylmethyl)-5-methyltriazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C13H14N6
|
1
|
| 1 |
IC50 = 41.9 nM
|
|
|
|
CP0226391
|
4-[2-(cyclobutylmethyl)-5-methyltriazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C14H16N6
|
1
|
| 1 |
IC50 = 62.7 nM
|
|
|
|
CP0226386
|
5-[4-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)triazol-2-yl]pentanenitrile
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|
C14H15N7
|
1
|
| 1 |
IC50 = 63.6 nM
|
|
|
|
CP0469798
|
4-[5-methyl-2-(2-methylprop-2-enyl)triazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C13H14N6
|
1
|
| 1 |
IC50 = 67.4 nM
|
|
|
|
CP0338889
|
N-(1-cyclopropylethyl)-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C18H18N4O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0363175
|
4-[2-(cyclopentylmethyl)-5-methyltriazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C15H18N6
|
1
|
| 1 |
IC50 = 71.8 nM
|
|
|
|
CP0273748
|
4-[4-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)triazol-2-yl]butanenitrile
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|
C13H13N7
|
1
|
| 1 |
IC50 = 73.5 nM
|
|
|
|
CP0016132
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C23H25N5O3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0273747
|
4-[5-methyl-2-(4,4,4-trifluorobutyl)triazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C13H13F3N6
|
1
|
| 1 |
IC50 = 96.3 nM
|
|
|
|
CP0164266
|
3-[4-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)triazol-2-yl]propan-1-ol
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|
C12H14N6O
|
1
|
| 1 |
IC50 = 156 nM
|
|
|
|
CP0164268
|
6-[4-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)triazol-2-yl]hexanenitrile
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|
C15H17N7
|
1
|
| 1 |
IC50 = 165 nM
|
|
|
|
CP0025303
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1R)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C23H25N5O3
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0437997
|
4-[2-(2-methoxyethyl)-5-methyltriazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C12H14N6O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0055660
|
2-phenoxy-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C16H16N4O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0067047
|
2-(3-methylphenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C17H18N4O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0359272
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(2R)-1-(3-cyanoazetidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C28H31N7O4
|
1
|
| 1 |
IC50 = 446 nM
|
|
|
|
CP0226387
|
4-(5-methyl-2-prop-2-enyltriazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine
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|
C12H12N6
|
1
|
| 1 |
IC50 = 511 nM
|
|
|
|
CP0067045
|
2-(2,3-dihydro-1H-inden-5-yloxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C19H20N4O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0538078
|
4-[5-methyl-2-(3-methylbut-2-enyl)triazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine
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|
C14H16N6
|
1
|
| 1 |
IC50 = 786 nM
|
|
|
|
CP0216006
|
2-(4-cyanophenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C17H15N5O2
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0220550
|
2-(3,5-dimethoxyphenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C18H20N4O4
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0283299
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C21H23N5O3
|
1
|
| 1 |
IC50 = 1010 nM
|
|
|
|
CP0067046
|
2-(3-ethylphenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C18H20N4O2
|
1
|
| 1 |
IC50 = 1210 nM
|
|
|
|
CP0220549
|
2-(3-cyanophenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C17H15N5O2
|
1
|
| 1 |
IC50 = 1250 nM
|
|
|
|
CP0054533
|
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C25H25N7O4
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0224529
|
2-[[(3S)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C21H23N5O3
|
1
|
| 1 |
IC50 = 1710 nM
|
|
|
|
CP0156241
|
2-(2-methylphenoxy)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
C17H18N4O2
|
1
|
| 1 |
IC50 = 2320 nM
|
|
|
|
CP0072678
|
5-(1,3-benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine
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|
C20H21N5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
