| Compound ID |
Compound Name |
Compound Formula |
|
CP0507566
|
3-(4-ethoxyphenyl)-N-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]triazolo[4,5-d]pyrimidin-5-amine
Show/Hide
|
C21H25N9O
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0548555
|
N-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-(1-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-5-amine
Show/Hide
|
C17H21N11
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0548561
|
3-(4-methoxyphenyl)-N-[(3R)-1-pyridin-4-ylpyrrolidin-3-yl]triazolo[4,5-d]pyrimidin-5-amine
Show/Hide
|
C20H20N8O
|
2
|
| 1 |
IC50 = 78 nM
|
|
|
| 2 |
IC50 = 93 nM
|
|
|
|
CP0553235
|
5-fluoro-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]triazolo[4,5-d]pyrimidin-3-yl]benzonitrile
Show/Hide
|
C20H19FN10
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 244 nM
|
|
|
|
CP0451009
|
N-[4-(aminomethyl)cyclohexyl]-3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-amine
Show/Hide
|
C18H23N7O
|
3
|
| 1 |
IC50 = 138 nM
|
|
|
| 2 |
IC50 = 227 nM
|
|
|
| 3 |
Kd = 2200 nM
|
|
|
|
CP0444137
|
(1R,3R)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
Show/Hide
|
C16H19N7O
|
3
|
| 1 |
IC50 = 158 nM
|
|
|
| 2 |
IC50 = 274 nM
|
|
|
| 3 |
Kd = 180 nM
|
|
|
|
CP0451006
|
4-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine
Show/Hide
|
C17H21N7O
|
3
|
| 1 |
IC50 = 300 nM
|
|
|
| 2 |
IC50 = 504 nM
|
|
|
| 3 |
Kd = 890 nM
|
|
|
|
CP0551813
|
(1S,3R)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
Show/Hide
|
C16H19N7O
|
2
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
IC50 = 2200 nM
|
|
|
|
CP0451007
|
(1S,3S)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
Show/Hide
|
C16H19N7O
|
2
|
| 1 |
IC50 = 1330 nM
|
|
|
| 2 |
IC50 = 1570 nM
|
|
|
|
CP0451008
|
3-(4-methoxyphenyl)-N-[(3S)-1-pyridin-4-ylpyrrolidin-3-yl]triazolo[4,5-d]pyrimidin-5-amine
Show/Hide
|
C20H20N8O
|
2
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 = 4500 nM
|
|
|
|
CP0552747
|
(1R,3S)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
Show/Hide
|
C16H19N7O
|
2
|
| 1 |
IC50 = 4600 nM
|
|
|
| 2 |
IC50 = 8200 nM
|
|
|
|
CP0553236
|
[4-[[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]amino]cyclohexyl]methanol
Show/Hide
|
C18H22N6O2
|
3
|
| 1 |
IC50 = 5400 nM
|
|
|
| 2 |
IC50 > 30000 nM
|
|
|
| 3 |
Kd = 5600 nM
|
|
|
|
CP0955839
|
(1R,3R)-N3-[3-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
Show/Hide
|
C17H20N6O
|
2
|
| 1 |
IC50 = 5500 nM
|
|
|
| 2 |
IC50 = 7200 nM
|
|
|
|
CP0551811
|
(1R,3R)-3-N-[1-(4-methoxyphenyl)triazolo[4,5-c]pyridin-6-yl]cyclopentane-1,3-diamine
Show/Hide
|
C17H20N6O
|
2
|
| 1 |
IC50 = 8000 nM
|
|
|
| 2 |
IC50 = 11000 nM
|
|
|
|
CP0560233
|
(1R,3R)-3-N-[9-(4-methoxyphenyl)purin-2-yl]cyclopentane-1,3-diamine
Show/Hide
|
C17H20N6O
|
2
|
| 1 |
IC50 = 9400 nM
|
|
|
| 2 |
IC50 > 30000 nM
|
|
|
|
CP0554919
|
(1R,3S)-3-N-[1-(4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-6-yl]cyclopentane-1,3-diamine
Show/Hide
|
C17H20N6O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0573248
|
CHEMBL4794701
Show/Hide
|
C18H21N7O2
|
1
|
| 1 |
Kd = 1100 nM
|
|
|
|
CP0095473
|
US10525036, Example GDC-0994
Show/Hide
|
C21H18ClFN6O2
|
1
|
| 1 |
Kd = 25000 nM
|
|
|
