General Information of the Protein
Protein ID
PT00212
Protein Name
Phosphodiesterase
Gene Name
PDEB1
Sequence
MFMNKPFGSKRCEPFHESEHLCEAFAITEAILARYQRGKRSFTSSEKSGLAALIKRIPYDILVEVLDQSGFTPTSNATPPVDYLAMMEHTMTHGASITHALQYLNDLMTKCTGCPGIRTYYHNPNDDVLADPVHDTAALIDETTAVGKSVVTKQYLNIAGAHYIPLIHGDIVVGCVEVPRFSGNLEKLPSFPSLIRAVTCTAHKFIEEARINWNREKAEAMLQMATRLARDNLDETVLASSIMNTVKSLTESARCSLFLVKDDKLEAHFEDGNVVSIPKGTGIVGYVAQTGETVNIVDAYADDRFNREVDKATGYRTKTILCMPVMYEGTIVAVTQLINKLDLTTESGLRLPRVFGKRDEELFQTFSMFAGASLRNCRINDRLLKEKKKSDVILDVVTVLSNTDIRDVDGIVRHALHGAKKLLNADRSTLFLVDKERNELCSRMADSVAGKEIRFPCGQGIAGTVAASGVGENIQDAYQDPRFNREVDKQLGYRTQTILCEPIILNGEILAVVQLVNKLDTSGEVTVFTEDDRDTFRVFSLFAGISINNSHLLEFAVKAGREVMELNEHRATLFNKNVPSRAVKRVTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMAKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKSNRAQWERVLETRLSTSSGNNSSTR
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Organism
Trypanosoma brucei
Protein Classification
Enzyme
Uniprot ID
Q8WQX9
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0014732
 Compound Info 
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H40N6O4
  2
1
IC50 = 4 nM
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2
Ki = 3.981 nM
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CP0015304
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C30H38N6O4
  1
1
IC50 = 49 nM
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CP0513871
 Compound Info 
4-[4-[5-(1-cycloheptyl-4,4-dimethyl-5-oxopyrazol-3-yl)-2-methoxyphenoxy]butoxy]benzonitrile
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C30H37N3O4
  1
1
IC50 = 160 nM
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CP0456943
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-(naphthalen-1-ylmethoxy)phenyl]-4,4-dimethylpyrazol-3-one
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C30H34N2O3
  1
1
IC50 = 250 nM
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CP0534197
 Compound Info 
5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C26H32N6O4
  1
1
IC50 = 400 nM
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CP0500275
 Compound Info 
2-cycloheptyl-5-(3-cyclopentyloxy-4-methoxyphenyl)-4,4-dimethylpyrazol-3-one
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C24H34N2O3
  1
1
IC50 = 410 nM
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CP0527380
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-(pyridin-2-ylmethoxy)phenyl]-4,4-dimethylpyrazol-3-one
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C25H31N3O3
  1
1
IC50 = 500 nM
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CP0541097
 Compound Info 
2-cycloheptyl-5-(4-methoxy-3-phenylmethoxyphenyl)-4,4-dimethylpyrazol-3-one
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C26H32N2O3
  1
1
IC50 = 500 nM
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CP0500272
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-[2-(4-methoxyphenyl)ethoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C28H36N2O4
  1
1
IC50 = 630 nM
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CP0542307
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-[(5-methyl-1,2-oxazol-3-yl)methoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C24H31N3O4
  1
1
IC50 = 630 nM
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CP0453876
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-[(4-methoxyphenyl)methoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C27H34N2O4
  1
1
IC50 = 790 nM
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CP0453877
 Compound Info 
5-[4-methoxy-3-(naphthalen-1-ylmethoxy)phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C26H28N2O3
  1
1
IC50 = 790 nM
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CP0513872
 Compound Info 
5-[4-methoxy-3-[2-(4-methoxyphenyl)ethoxy]phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C24H30N2O4
  1
1
IC50 = 830 nM
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CP0500274
 Compound Info 
5-(4-methoxy-3-phenylmethoxyphenyl)-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C22H26N2O3
  1
1
IC50 = 1000 nM
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CP0527347
 Compound Info 
4-[[5-(1-cycloheptyl-4,4-dimethyl-5-oxopyrazol-3-yl)-2-methoxyphenoxy]methyl]benzonitrile
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C27H31N3O3
  1
1
IC50 = 1000 nM
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CP0515884
 Compound Info 
5-[4-methoxy-3-[(4-methoxyphenyl)methoxy]phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C23H28N2O4
  1
1
IC50 = 2000 nM
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CP0515885
 Compound Info 
4-[[5-(4,4-dimethyl-5-oxo-1-propan-2-ylpyrazol-3-yl)-2-methoxyphenoxy]methyl]benzonitrile
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C23H25N3O3
  1
1
IC50 = 2000 nM
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CP0525954
 Compound Info 
5-(3-chloro-4-methoxyphenyl)-2-cycloheptyl-4,4-dimethylpyrazol-3-one
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C19H25ClN2O2
  1
1
IC50 = 2000 nM
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CP0527348
 Compound Info 
5-[4-methoxy-3-(pyridin-2-ylmethoxy)phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C21H25N3O3
  1
1
IC50 = 2500 nM
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CP0553568
 Compound Info 
5-(3-bromo-4-methoxyphenyl)-2-cycloheptyl-4,4-dimethylpyrazol-3-one
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C19H25BrN2O2
  1
1
IC50 = 2500 nM
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CP0534199
 Compound Info 
4-[4-[5-(4,4-dimethyl-5-oxo-1-propan-2-ylpyrazol-3-yl)-2-methoxyphenoxy]butoxy]benzonitrile
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C26H31N3O4
  1
1
IC50 = 5000 nM
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CP0534200
 Compound Info 
5-[4-methoxy-3-[(5-methyl-1,2-oxazol-3-yl)methoxy]phenyl]-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C20H25N3O4
  1
1
IC50 = 5000 nM
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CP0527349
 Compound Info 
3-(4-methoxy-3-phenylmethoxyphenyl)-4,4-dimethyl-1H-pyrazol-5-one
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C19H20N2O3
  1
1
IC50 = 6300 nM
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CP0488654
 Compound Info 
5-(4-methoxy-3-phenylmethoxyphenyl)-2,4,4-trimethylpyrazol-3-one
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C20H22N2O3
  1
1
IC50 = 10000 nM
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CP0495606
 Compound Info 
2-cycloheptyl-5-(3-hydroxy-4-methoxyphenyl)-4,4-dimethylpyrazol-3-one
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C19H26N2O3
  1
1
IC50 > 10000 nM
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CP0534201
 Compound Info 
3-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5-one
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C12H13BrN2O2
  1
1
IC50 > 10000 nM
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CP0534202
 Compound Info 
3-(3-chloro-4-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5-one
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C12H13ClN2O2
  1
1
IC50 > 10000 nM
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CP0534203
 Compound Info 
5-(3-hydroxy-4-methoxyphenyl)-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C15H20N2O3
  1
1
IC50 > 10000 nM
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CP0541095
 Compound Info 
5-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C15H19BrN2O2
  1
1
IC50 > 10000 nM
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CP0541096
 Compound Info 
5-(3-chloro-4-methoxyphenyl)-4,4-dimethyl-2-propan-2-ylpyrazol-3-one
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C15H19ClN2O2
  1
1
IC50 > 10000 nM
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CP0500801
 Compound Info 
5-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-3-methyl-7-(2-methylpropyl)-1-propylpyrimido[4,5-d]pyrimidine-2,4-dione
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C22H25ClN4O3S
  1
1
IC50 = 10000 nM
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CP0544551
 Compound Info 
3-(3-cyclopentyloxy-4-methoxyphenyl)-4,4-dimethyl-1H-pyrazol-5-one
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C17H22N2O3
  1
1
IC50 = 12000 nM
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CP0519735
 Compound Info 
1-morpholin-4-yl-4-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylbutan-1-one
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C20H21N3O2S2
  1
1
IC50 = 12000 nM
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CP0038742
 Compound Info 
1-(3,4-Dihydroxy-phenyl)-2-(2,5-dimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidin-7-ylsulfanyl)-ethanone
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C22H19N3O3S
  1
1
IC50 = 13000 nM
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CP0418440
 Compound Info 
N-cyclopropyl-4-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-(furan-2-ylmethyl)butanamide
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C24H22N2O4
  1
1
IC50 = 41000 nM
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CP0449722
 Compound Info 
3-(3-oxo-3-piperidin-1-ylpropyl)-1-(2-phenylethyl)quinoxalin-2-one
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C24H27N3O2
  1
1
IC50 = 54000 nM
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CP0438413
 Compound Info 
N-[[4-(1,2,4-triazol-1-ylmethyl)phenyl]methyl]-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
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C23H23N5O
  1
1
IC50 = 75000 nM
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CP0037308
 Compound Info 
(R,S)-Rolipram
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C16H21NO3
  1
1
IC50 > 100000 nM
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CP0234672
 Compound Info 
4-[5-[(4aR,8aS)-4-oxo-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)benzamide
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C27H30N4O4
  1
1
Ki = 100 nM
 Bioactivity Info 
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CP0491376
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzamide
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C29H33N3O3
  1
1
Ki = 158.49 nM
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CP0404125
 Compound Info 
(4aS,8aR)-4-[3-[4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl]-4-methoxyphenyl]-2-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-one
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C29H33N3O4
  1
1
Ki = 199.53 nM
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CP0511657
 Compound Info 
(4aS,8aR)-2-cycloheptyl-4-[3-[4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl]-4-methoxyphenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H39N3O4
  1
1
Ki = 251.19 nM
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CP0404148
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-methoxyethyl)benzamide
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C32H39N3O4
  1
1
Ki = 316.23 nM
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CP0404147
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)-N-methylbenzamide
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C32H38N4O4
  1
1
Ki = 398.11 nM
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CP0482143
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(2-hydroxyethylamino)-2-oxoethyl]benzamide
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C33H40N4O5
  1
1
Ki = 398.11 nM
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CP0550300
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(methylamino)-2-oxoethyl]benzamide
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C32H38N4O4
  1
1
Ki = 398.11 nM
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CP0408770
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(2-methoxyethylamino)-2-oxoethyl]benzamide
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C34H42N4O5
  1
1
Ki = 501.19 nM
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CP0408772
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzonitrile
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C29H31N3O2
  1
1
Ki = 501.19 nM
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CP0511661
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(3-amino-3-oxopropyl)benzamide
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C32H38N4O4
  1
1
Ki = 501.19 nM
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CP0557344
 Compound Info 
(2R)-1-[4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoyl]pyrrolidine-2-carboxamide
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C34H40N4O4
  1
1
Ki = 501.19 nM
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CP0408769
 Compound Info 
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(4-oxoimidazolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C32H36N4O4
  1
1
Ki = 630.96 nM
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CP0550299
 Compound Info 
(2R)-1-[4-[5-[(4aR,8aS)-4-oxo-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoyl]pyrrolidine-2-carboxamide
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C30H34N4O4
  1
1
Ki = 630.96 nM
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CP0529366
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-acetamidoethyl)benzamide
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C33H40N4O4
  1
1
Ki = 794.33 nM
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CP0560123
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-(dimethylamino)-2-oxoethyl]benzamide
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C33H40N4O4
  1
1
Ki = 794.33 nM
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CP0569359
 Compound Info 
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(3-oxopyrrolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H37N3O4
  1
1
Ki = 1000 nM
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CP0482148
 Compound Info 
(4aS,8aR)-2-cycloheptyl-4-[4-methoxy-3-[4-(3-methyl-4-oxoimidazolidine-1-carbonyl)phenyl]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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C33H38N4O4
  1
1
Ki = 1584.89 nM
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CP0491377
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoic acid
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C29H32N2O4
  1
1
Ki = 1584.89 nM
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CP0511659
 Compound Info 
4-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]benzamide
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C34H42N4O4
  1
1
Ki = 1995.26 nM
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CP0035728
 Compound Info 
3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
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C17H14Cl2F2N2O3
  1
1
Ki = 3162.28 nM
 Bioactivity Info 
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CP0408771
 Compound Info 
4-[5-[(4aS,8aR)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]-N-(2-amino-2-oxoethyl)benzamide
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C31H36N4O4
  1
1
Ki = 3981.07 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511660
 Compound Info 
3-[5-[(4aR,8aS)-3-cycloheptyl-4-oxo-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxyphenyl]benzoic acid
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C29H32N2O4
  1
1
Ki = 7943.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00671 Phosphodiesterase Leishmania major
 Protein Info