| Compound ID |
Compound Name |
Compound Formula |
|
CP0026342
|
3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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|
C17H13N3O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0559176
|
(3R)-N-[5-[(2S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
Show/Hide
|
C21H22F2N6O2
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0555714
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-morpholin-4-ylbenzamide
Show/Hide
|
C25H27F2N5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0419166
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C26H30F2N6O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0494238
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C26H30F2N6O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0553600
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-morpholin-4-ylbenzamide
Show/Hide
|
C25H27F2N5O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0558784
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(dimethylamino)benzamide
Show/Hide
|
C23H25F2N5O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0494239
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-[4-[(3,5-difluorophenyl)methyl]-4-methylpiperazin-4-ium-1-yl]benzamide;bromide
Show/Hide
|
C33H35BrF4N6O
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0548265
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-(dimethylamino)benzamide
Show/Hide
|
C23H25F2N5O
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0419168
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-morpholin-4-ylbenzamide
Show/Hide
|
C25H27F2N5O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0555715
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C26H30F2N6O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0548263
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]quinoline-6-carboxamide
Show/Hide
|
C24H21F2N5O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0487459
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0553598
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0558217
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-fluorobenzamide
Show/Hide
|
C21H19F3N4O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0559175
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C26H30F2N6O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0467044
|
N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]-2-hydroxybenzamide
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|
C14H12N2O4
|
1
|
| 1 |
IC50 = 231.5 nM
|
|
|
|
CP0012721
|
[3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]azetidin-1-yl]-[4-[[(2S)-2,3-dihydroxypropoxy]methyl]pyridin-2-yl]methanone
Show/Hide
|
C30H34N2O6
|
1
|
| 1 |
IC50 = 261 nM
|
|
|
|
CP0559173
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-morpholin-4-ylbenzamide
Show/Hide
|
C25H27F2N5O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0561417
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-(dimethylamino)benzamide
Show/Hide
|
C23H25F2N5O
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0548264
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-4-fluorobenzamide
Show/Hide
|
C21H19F3N4O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0464410
|
2-hydroxy-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]benzamide
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|
C14H12N2O5
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0559174
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-(dimethylamino)benzamide
Show/Hide
|
C23H25F2N5O
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0548262
|
N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]naphthalene-2-carboxamide
Show/Hide
|
C25H22F2N4O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0559172
|
N-[5-[(2-fluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21FN4O
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0553599
|
N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]naphthalene-2-carboxamide
Show/Hide
|
C25H22F2N4O
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0487487
|
N-[5-[(3-fluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21FN4O
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0558783
|
N-[5-[(2,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0494236
|
N-[5-[(2,6-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0562149
|
N-[6,6-dimethyl-5-[(3-nitrophenyl)methyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21N5O3
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0561416
|
N-[5-[(3-chlorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21ClN4O
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0575706
|
N-[5-[(3,4-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0569776
|
4-bromo-N-[5-[(3,5-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H19BrF2N4O
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
|
CP0548259
|
N-[5-[(2-fluoro-5-methylphenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H23FN4O
|
1
|
| 1 |
IC50 = 880 nM
|
|
|
|
CP0494235
|
N-[5-[(3-bromophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21BrN4O
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0494237
|
N-[5-[(3-fluoro-4-methylphenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H23FN4O
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0558218
|
4-bromo-N-[5-[(2,3-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H19BrF2N4O
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0548257
|
N-[5-[(3-cyanophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H21N5O
|
1
|
| 1 |
IC50 = 980 nM
|
|
|
|
CP0557743
|
N-[5-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H20F4N4O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0548256
|
N-[6,6-dimethyl-5-[(3-methylphenyl)methyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H24N4O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0561415
|
N-[5-[(3-methoxyphenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C22H24N4O2
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0534456
|
N-[5-[(4-fluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21FN4O
|
1
|
| 1 |
IC50 = 1180 nM
|
|
|
|
CP0471251
|
N-(5-benzyl-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl)benzamide
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
IC50 = 1240 nM
|
|
|
|
CP0548258
|
N-[5-[(3-iodophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H21IN4O
|
1
|
| 1 |
IC50 = 1360 nM
|
|
|
|
CP0717983
|
2-(4-Methoxyphenyl)-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C25H25N5O
|
1
|
| 1 |
IC50 = 1440 nM
|
|
|
|
CP0841521
|
N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
IC50 = 1450 nM
|
|
|
|
CP0565379
|
N-[5-[(2,4-difluorophenyl)methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H20F2N4O
|
1
|
| 1 |
IC50 = 2320 nM
|
|
|
|
CP0747495
|
2-(4-methoxyphenyl)-N-(4-morpholinophenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 2480 nM
|
|
|
|
CP0208873
|
N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-2-hydroxybenzamide
Show/Hide
|
C14H12N2O4
|
1
|
| 1 |
IC50 = 2545 nM
|
|
|
|
CP0726868
|
2-phenyl-N-(4-(piperidin-1-yl)phenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 = 3230 nM
|
|
|
|
CP0761937
|
3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 = 3420 nM
|
|
|
|
CP0670159
|
2-(4-methoxyphenyl)-N-(4-(piperidin-1-yl)phenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C25H25N5O
|
1
|
| 1 |
IC50 = 3720 nM
|
|
|
|
CP0747494
|
N-(4-morpholinophenyl)-2-phenylpyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C23H21N5O
|
1
|
| 1 |
IC50 = 5320 nM
|
|
|
|
CP0717984
|
2-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 = 5810 nM
|
|
|
|
CP0726601
|
2-(4-Methoxyphenyl)-N-(4-morpholin-4-ylphenyl)pyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 6690 nM
|
|
|
|
CP0548261
|
N-[6,6-dimethyl-5-[(3,4,5-trifluorophenyl)methyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C21H19F3N4O
|
1
|
| 1 |
IC50 = 6960 nM
|
|
|
|
CP0674969
|
N-phenyl-2-(4-(piperidin-1-yl)phenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 = 7790 nM
|
|
|
|
CP0663577
|
2-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 = 9240 nM
|
|
|
|
CP0670157
|
N-(3-methoxyphenyl)-2-(4-(piperidin-1-yl)phenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C25H25N5O
|
1
|
| 1 |
IC50 = 9360 nM
|
|
|
|
CP0726600
|
N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C23H21N5O
|
1
|
| 1 |
IC50 = 13740 nM
|
|
|
|
CP0548260
|
N-[5-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide
Show/Hide
|
C23H20F6N4O
|
1
|
| 1 |
IC50 = 16360 nM
|
|
|
|
CP0660964
|
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C20H16N4O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0674971
|
N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C20H16N4O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0674998
|
N-(4-Methoxyphenyl)-N'-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Show/Hide
|
C21H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0680579
|
N-(2-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C20H16N4O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0691194
|
N-Allyl-N'-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0691195
|
N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Show/Hide
|
C21H14N4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0691196
|
3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0717884
|
N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C24H23N5
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0717985
|
N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C25H25N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0726598
|
N-(3-Methoxyphenyl)-N'-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Show/Hide
|
C21H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0726599
|
N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine
Show/Hide
|
C19H12ClFN4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0726602
|
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Show/Hide
|
C20H16N4O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0726603
|
N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Show/Hide
|
C23H21N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0731455
|
N-Ethyl-N'-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
Show/Hide
|
C16H15N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0761933
|
N-(3-Methoxyphenyl)-N'-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
Show/Hide
|
C21H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0106653
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5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
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C17H19ClFN7O
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1
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| 1 |
Kd = 0.204 nM
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CP0542725
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N-(5-tert-butyl-2-phenylpyrazol-3-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide
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C22H23N7OS
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1
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| 1 |
Kd = 7.78 nM
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CP0230588
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1-[5-[(7-methyl-4-oxopyrido[1,2-a]pyrimidin-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]-3-[3-(trifluoromethyl)phenyl]urea
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C20H15F3N6O2S2
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1
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| 1 |
Kd = 11.4 nM
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