Protein Information

General Information of the Protein

Protein ID	PT00821
Protein Name	Interleukin-1 receptor-associated kinase 4
Secondarily Protein Name	Renal carcinoma antigen NY-REN-64
Gene Name	IRAK4
Sequence	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > TKL protein kinase group > TKL protein kinase IRAK family
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. Show/Hide
Uniprot ID	Primary ID: Q9NWZ3 Secondarily ID: Q69FE1 Q8TDF7 Q9Y589 Show/Hide
Ensembl ID	ENSG00000198001
HGNC ID	HGNC:17967
Subcellular Location	Cytoplasm

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000300 , Karpas-299

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0569977 Compound Info	2-[[1-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H27FN8O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0577917 Compound Info	2-[[1-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H33N9O2	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0549798 Compound Info	2-[[1-[(2S,4S)-1,2-dimethylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H30N8O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0465849 Compound Info	1-N-(5-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C19H29N5	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0552888 Compound Info	4-N,4-N-dimethyl-1-N-(5-propan-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C17H27N5	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0576617 Compound Info	6-methyl-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0511740 Compound Info	CHEMBL4104802 Show/Hide	C24H37N7O2	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0541561 Compound Info	4-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]sulfanyl]cyclohexyl]morpholine Show/Hide	C21H30N4O2S	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0454478 Compound Info	(3aR,7aS)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-one Show/Hide	C25H36N6O2	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0576616 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H28N8O	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0560318 Compound Info	(3aS,7aR)-1-methyl-5-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3a,4,6,7,7a-hexahydropyrrolo[3,2-c]pyridin-2-one Show/Hide	C25H36N6O2	1
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0571715 Compound Info	1-N-(5-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C18H27N5	1
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0569551 Compound Info	2-[[1-[(3S,4S)-3-fluoro-1-methylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H27FN8O	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0580162 Compound Info	N,N-dimethyl-2-[4-[4-[[6-methyl-4-[(1-methylcyclopropyl)amino]-5-oxopyrido[4,3-d]pyrimidin-2-yl]amino]pyrazol-1-yl]piperidin-1-yl]acetamide Show/Hide	C24H33N9O2	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0567714 Compound Info	2-[[1-(1-acetylpiperidin-4-yl)pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O2	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0577163 Compound Info	2-[[1-[(2R,4S)-1,2-dimethylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H30N8O	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0086424 Compound Info	CHEMBL4064608 Show/Hide	C21H31N5O2	1
1	IC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0568277 Compound Info	6-[(2S)-2-fluoropropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0549786 Compound Info	CHEMBL4080574 Show/Hide	C23H34N6O2	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0454472 Compound Info	4-N,4-N-dimethyl-1-N-[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine Show/Hide	C19H29N5O	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0560315 Compound Info	1-N-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C16H25N5	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0454566 Compound Info	4-N,4-N-dimethyl-1-N-[5-(oxan-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine Show/Hide	C19H29N5O	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0575843 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(2H-triazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H27N11O	1
1	IC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0577165 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-ylpyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H28N10O	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0551235 Compound Info	6-cyclopropyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H30N8O	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0571716 Compound Info	1-N-(5-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C17H25N5	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0577162 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methyl-6-oxopiperidin-3-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H26N8O2	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0578381 Compound Info	6-[(2S)-2-fluoropropyl]-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H31FN8O	1
1	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0389257 Compound Info	methyl 4-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate Show/Hide	C23H34N6O3	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0567968 Compound Info	6-(2,2-difluoroethyl)-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28F2N8O	1
1	IC50 = 83 nM Bioactivity Info	TI LI LO TS
CP0575750 Compound Info	6-(2,2-difluoroethyl)-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H28F2N8O	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0577013 Compound Info	6-methyl-2-[[1-[(1S,4S,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0576618 Compound Info	6-[(2R)-2-fluoropropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0577161 Compound Info	2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]acetonitrile Show/Hide	C17H18N8	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0389256 Compound Info	N-[4-(4-methylsulfonylpiperazin-1-yl)cyclohexyl]-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Show/Hide	C22H34N6O3S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0577166 Compound Info	6-[(2S)-2-fluoropropyl]-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H31FN8O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0454567 Compound Info	4-N,4-N-dimethyl-1-N-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C15H23N5	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0567943 Compound Info	6-(2,2-difluoroethyl)-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H28F2N8O	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0568575 Compound Info	methyl 4-[4-[[6-methyl-2-[(1-methylpyrazol-4-yl)amino]-5-oxopyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate Show/Hide	C24H33N9O3	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0575842 Compound Info	6-[(2S)-1-fluoropropan-2-yl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0571721 Compound Info	4-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]cyclohexyl]morpholine Show/Hide	C21H30N4O3	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0551236 Compound Info	6-(difluoromethyl)-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H26F2N8O	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0577164 Compound Info	6-[(2R)-1-fluoropropan-2-yl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0481796 Compound Info	methyl 4-[4-[[6-methyl-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate Show/Hide	C24H33N9O2	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0576619 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(1-methyltriazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H29N11O	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0569976 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C16H19N7O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0572059 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-propan-2-ylpyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H32N8O	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0541460 Compound Info	4-N,4-N-dimethyl-1-N-[5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine Show/Hide	C15H20F3N5	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0454477 Compound Info	N,N-dimethyl-1-[4-[[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperidine-4-carboxamide Show/Hide	C25H38N6O2	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0541459 Compound Info	CHEMBL4097089 Show/Hide	C19H28N4O2	1
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0390068 Compound Info	4-[(4-morpholin-4-ylcyclohexyl)amino]-3-(oxan-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile Show/Hide	C23H31N5O2	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0551234 Compound Info	6-methyl-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0569611 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(1H-1,2,4-triazol-5-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H27N11O	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0563116 Compound Info	N-(4-morpholin-4-ylcyclohexyl)-3-(oxan-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine Show/Hide	C22H32N4O2	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0423188 Compound Info	1-N,1-N,4-N-trimethyl-4-N-[5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine Show/Hide	C20H31N5O	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0576615 Compound Info	methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxopyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate Show/Hide	C25H32N10O3	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0454475 Compound Info	4-N,4-N-dimethyl-1-N-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-yl)cyclohexane-1,4-diamine Show/Hide	C17H24N4S	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0572060 Compound Info	2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]-6-(1-methyltriazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H29N11O	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0571717 Compound Info	1-N-(5-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C18H29N5	1
1	IC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0571718 Compound Info	4-N,4-N-dimethyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C14H21N5	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0571720 Compound Info	4-N,4-N-dimethyl-1-N-(7,9,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)cyclohexane-1,4-diamine Show/Hide	C17H25N5	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0541461 Compound Info	1-N-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C16H24N4S	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0436787 Compound Info	N-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Show/Hide	C21H31N5O2	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0465850 Compound Info	4-N,4-N-dimethyl-1-N-(6-methylthieno[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C15H22N4S	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0549787 Compound Info	4-N,4-N-dimethyl-1-N-(5-methylthieno[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C15H22N4S	1
1	IC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0454474 Compound Info	4-N,4-N-dimethyl-1-N-thieno[2,3-d]pyrimidin-4-ylcyclohexane-1,4-diamine Show/Hide	C14H20N4S	1
1	IC50 = 8400 nM Bioactivity Info	TI LI LO TS
CP0571719 Compound Info	1-N-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine Show/Hide	C16H25N5	1
1	IC50 = 23000 nM Bioactivity Info	TI LI LO TS
CP0560316 Compound Info	4-N,4-N-dimethyl-1-N-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclohexane-1,4-diamine Show/Hide	C15H23N5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000091 , MV4-11

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Cell Line ID: CL000012 , Sf21

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Cell Line ID: CL000864 , THP1-Xblue

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0081693 Compound Info	1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide Show/Hide	C18H20FN3O4	2
1	IC50 = 0.2 nM
2	IC50 = 2 nM
CP0224957 Compound Info	N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C21H24F3N5O2	1
1	IC50 = 0.55 nM
CP0549798 Compound Info	2-[[1-[(2S,4S)-1,2-dimethylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H30N8O	1
1	IC50 = 0.6 nM
CP0569977 Compound Info	2-[[1-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H27FN8O	1
1	IC50 = 0.6 nM
CP0067182 Compound Info	(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol Show/Hide	C26H28N6O3	1
1	IC50 = 0.74 nM
CP0580162 Compound Info	N,N-dimethyl-2-[4-[4-[[6-methyl-4-[(1-methylcyclopropyl)amino]-5-oxopyrido[4,3-d]pyrimidin-2-yl]amino]pyrazol-1-yl]piperidin-1-yl]acetamide Show/Hide	C24H33N9O2	1
1	IC50 = 0.8 nM
CP0569551 Compound Info	2-[[1-[(3S,4S)-3-fluoro-1-methylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H27FN8O	1
1	IC50 = 1 nM
CP0575843 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(2H-triazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H27N11O	1
1	IC50 = 1 nM
CP0576616 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H28N8O	1
1	IC50 = 1 nM
CP0576617 Compound Info	6-methyl-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 1 nM
CP0577163 Compound Info	2-[[1-[(2R,4S)-1,2-dimethylpiperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H30N8O	1
1	IC50 < 1 nM
CP0577917 Compound Info	2-[[1-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H33N9O2	1
1	IC50 = 1 nM
CP0567714 Compound Info	2-[[1-(1-acetylpiperidin-4-yl)pyrazol-4-yl]amino]-6-methyl-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O2	1
1	IC50 = 2 nM
CP0567968 Compound Info	6-(2,2-difluoroethyl)-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28F2N8O	1
1	IC50 = 2 nM
CP0568277 Compound Info	6-[(2S)-2-fluoropropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 2 nM
CP0577161 Compound Info	2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]acetonitrile Show/Hide	C17H18N8	1
1	IC50 = 2 nM
CP0577162 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methyl-6-oxopiperidin-3-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H26N8O2	1
1	IC50 = 2 nM
CP0577166 Compound Info	6-[(2S)-2-fluoropropyl]-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H31FN8O	1
1	IC50 = 2 nM
CP0136727 Compound Info	US9546153, ex. 42 Show/Hide	C21H24FN5O2S	1
1	IC50 = 2.4 nM
CP0233047 Compound Info	US9546153, ex. 35 Show/Hide	C21H26FN5O2S	1
1	IC50 = 2.4 nM
CP0551236 Compound Info	6-(difluoromethyl)-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C21H26F2N8O	1
1	IC50 = 3 nM
CP0577013 Compound Info	6-methyl-2-[[1-[(1S,4S,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 3 nM
CP0578381 Compound Info	6-[(2S)-2-fluoropropyl]-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H31FN8O	1
1	IC50 = 3 nM
CP0548642 Compound Info	N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-(propan-2-ylamino)-6-(pyrazolo[1,5-a]pyrimidin-5-ylamino)pyridine-3-carboxamide Show/Hide	C20H26FN7O2	1
1	IC50 = 3.2 nM
CP0531465 Compound Info	US9546153, ex. 367 Show/Hide	C20H25F2N7O2	1
1	IC50 = 3.4 nM
CP0553657 Compound Info	US9546153, ex. 41 Show/Hide	C20H25FN6O2S	1
1	IC50 = 3.5 nM
CP0095742 Compound Info	(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol Show/Hide	C26H28N6O3S	1
1	IC50 = 4 nM
CP0551235 Compound Info	6-cyclopropyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H30N8O	1
1	IC50 = 4 nM
CP0567943 Compound Info	6-(2,2-difluoroethyl)-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H28F2N8O	1
1	IC50 = 4 nM
CP0575750 Compound Info	6-(2,2-difluoroethyl)-2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H28F2N8O	1
1	IC50 = 4 nM
CP0575842 Compound Info	6-[(2S)-1-fluoropropan-2-yl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 4 nM
CP0577165 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-ylpyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H28N10O	1
1	IC50 = 4 nM
CP0139167 Compound Info	US9546153, ex. 8 Show/Hide	C21H27N5O2S	1
1	IC50 = 4.1 nM
CP0341632 Compound Info	US9546153, ex. 171 Show/Hide	C21H25F2N5O2S	1
1	IC50 = 4.3 nM
CP0218453 Compound Info	US9546153, ex. 143 Show/Hide	C23H23N5O3S	3
1	IC50 = 4.7 nM
2	IC50 = 5 nM
3	IC50 = 300 nM
CP0481796 Compound Info	CHEMBL4521212 Show/Hide	C24H33N9O2	2
1	IC50 = 5 nM
2	IC50 = 9 nM
CP0568575 Compound Info	CHEMBL5173450 Show/Hide	C24H33N9O3	1
1	IC50 = 5 nM
CP0572059 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-propan-2-ylpyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H32N8O	1
1	IC50 = 5 nM
CP0577164 Compound Info	6-[(2R)-1-fluoropropan-2-yl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 5 nM
CP0233072 Compound Info	US9546153, ex. 286 Show/Hide	C21H27FN6O2	1
1	IC50 = 5.2 nM
CP0136722 Compound Info	6-(1,3-benzothiazol-6-ylamino)-4-(propan-2-ylamino)-N-[2-(4-sulfamoylphenyl)ethyl]pyridine-3-carboxamide Show/Hide	C24H26N6O3S2	1
1	IC50 = 5.7 nM
CP0469086 Compound Info	N-[7-methoxy-2-(1-methylpiperidin-4-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C21H22F3N5O2	1
1	IC50 = 5.7 nM
CP0576619 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(1-methyltriazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H29N11O	1
1	IC50 = 6 nM
CP0576704 Compound Info	N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide Show/Hide	C24H28N6O3	1
1	IC50 = 7.7 nM
CP0067186 Compound Info	(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol Show/Hide	C25H26N6O4	1
1	IC50 = 8 nM
CP0422246 Compound Info	N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(2-methyl-1,3-benzothiazol-6-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide Show/Hide	C22H28FN5O2S	1
1	IC50 = 8 nM
CP0569976 Compound Info	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C16H19N7O	1
1	IC50 = 8 nM
CP0575182 Compound Info	N-[2-(3-hydroxy-3-methylbutyl)-7-methoxyindazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C20H21F3N4O3	1
1	IC50 = 8.3 nM
CP0224958 Compound Info	N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C22H25F3N4O3	1
1	IC50 = 8.6 nM
CP0351775 Compound Info	US9546153, ex. 45 Show/Hide	C20H25FN6O3	1
1	IC50 = 8.7 nM
CP0531787 Compound Info	US9546153, ex. 366 Show/Hide	C21H24FN5O2S	1
1	IC50 = 9.3 nM
CP0153113 Compound Info	6-(1,3-benzothiazol-6-ylamino)-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]-N-methylpyridine-3-carboxamide Show/Hide	C23H23N5O2S	2
1	IC50 = 10 nM
2	IC50 = 11 nM
CP0133598 Compound Info	US9546153, ex. 9 Show/Hide	C21H25N5O2S	1
1	IC50 = 10 nM
CP0577957 Compound Info	N-[2-(azetidin-3-yl)-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C20H20F3N5O2	1
1	IC50 = 10.6 nM
CP0272491 Compound Info	(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]cyclopentane-1,2-diol Show/Hide	C25H26N6O3S	1
1	IC50 = 11 nM
CP0707915 Compound Info	5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-morpholinopyrimidin-4(3H)-one Show/Hide	C21H25N5O5S	1
1	IC50 = 11 nM
CP0569611 Compound Info	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(1H-1,2,4-triazol-5-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H27N11O	1
1	IC50 = 11 nM
CP0184906 Compound Info	(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-[(2,6-dimethylpyridin-4-yl)amino]pyridin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol Show/Hide	C25H27N5O3S	1
1	IC50 = 14 nM
CP0572060 Compound Info	2-[[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]-6-(1-methyltriazol-4-yl)pyrido[4,3-d]pyrimidin-5-one Show/Hide	C24H29N11O	1
1	IC50 = 15 nM
CP0551234 Compound Info	6-methyl-2-[[1-[(1R,4R,5S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4-yl]amino]-4-[(1-methylcyclopropyl)amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C22H28N8O	1
1	IC50 = 16 nM
CP0552076 Compound Info	N-[2-[2-(diethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C23H28F3N5O2	1
1	IC50 = 16.7 nM
CP0716626 Compound Info	5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one Show/Hide	C21H25N5O4S	1
1	IC50 = 18 nM
CP0673999 Compound Info	(R)-5-(Benzo[d]thiazol-2-yl)-2-morpholino-6-(piperidin-3-ylamino)pyrimidin-4(3H)-one Show/Hide	C20H24N6O2S	3
1	IC50 = 19 nM
2	IC50 = 1900 nM
3	IC50 = 4200 nM
CP0321333 Compound Info	6-(1,3-benzothiazol-6-ylamino)-N-[(2R)-3-hydroxy-2,3-dimethylbutyl]-4-(propan-2-ylamino)pyridine-3-carboxamide Show/Hide	C22H29N5O2S	1
1	IC50 = 19 nM
CP0534231 Compound Info	6-(1,3-benzothiazol-6-ylamino)-N-methyl-4-(propan-2-ylamino)pyridine-3-carboxamide Show/Hide	C17H19N5OS	1
1	IC50 = 21 nM
CP0576618 Compound Info	6-[(2R)-2-fluoropropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one Show/Hide	C23H31FN8O	1
1	IC50 = 21 nM
CP0576615 Compound Info	CHEMBL5184305 Show/Hide	C25H32N10O3	1
1	IC50 = 23 nM
CP0422244 Compound Info	6-(1,3-benzothiazol-6-ylamino)-N-(3-hydroxypropyl)-4-(propan-2-ylamino)pyridine-3-carboxamide Show/Hide	C19H23N5O2S	1
1	IC50 = 24 nM
CP0184908 Compound Info	(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol Show/Hide	C27H30N6O4	1
1	IC50 = 27 nM
CP0659036 Compound Info	5-(Benzo[d]thiazol-2-yl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one Show/Hide	C26H27N5O4S	1
1	IC50 = 27 nM
CP0213894 Compound Info	N-(3-carbamoyl-1-methylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C15H15N7O2	1
1	IC50 = 32 nM
CP0554872 Compound Info	N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-4-(trifluoromethyl)-1,3-thiazole-2-carboxamide Show/Hide	C19H22F3N5O2S	1
1	IC50 = 34.8 nM
CP0576705 Compound Info	N-[2-[1-(2-cyanoacetyl)azetidin-3-yl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C23H21F3N6O3	1
1	IC50 = 36.7 nM
CP0224956 Compound Info	N-(7-methoxy-2-piperidin-4-ylindazol-5-yl)-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C20H20F3N5O2	1
1	IC50 = 41 nM
CP0067192 Compound Info	(1R,2S,3R,5R)-3-[[2-[(2-cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol Show/Hide	C27H28N6O4	1
1	IC50 = 44 nM
CP0455989 Compound Info	CHEMBL4070214 Show/Hide	C19H23N5O	1
1	IC50 = 46 nM
CP0577956 Compound Info	N-[6-(2-hydroxypropan-2-yl)-2-[[(2S)-5-oxopyrrolidin-2-yl]methyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C22H22F3N5O3	1
1	IC50 = 47 nM
CP0086424 Compound Info	CHEMBL4064608 Show/Hide	C21H31N5O2	1
1	IC50 = 51 nM
CP0573378 Compound Info	N-[2-(1-ethylsulfonylazetidin-3-yl)-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C22H24F3N5O4S	1
1	IC50 = 57 nM
CP0772723 Compound Info	2-(Azetidin-1-yl)-5-(benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one Show/Hide	C20H23N5O4S	1
1	IC50 = 67 nM
CP0724473 Compound Info	5-(benzo[d]thiazol-2-yl)-6-(((3R,5R)-5-hydroxypiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one Show/Hide	C20H24N6O3S	1
1	IC50 = 85 nM
CP0678448 Compound Info	5-(benzo[d]thiazol-2-yl)-6-(((3R,6R)-6-methylpiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one Show/Hide	C21H26N6O2S	2
1	IC50 = 93 nM
2	IC50 = 114 nM
CP0577954 Compound Info	N-[2-[2-(dimethylamino)ethyl]-7-methoxyindazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Show/Hide	C19H20F3N5O2	1
1	IC50 = 96 nM
CP0093353 Compound Info	US9169260, 18 Show/Hide	C23H25N7O3S	1
1	IC50 < 100 nM
CP0117420 Compound Info	US9169260, 37 Show/Hide	C25H29N7O	1
1	IC50 < 100 nM
CP0139326 Compound Info	US9169260, 53 Show/Hide	C25H27N7O3S	1
1	IC50 < 100 nM
CP0143321 Compound Info	US9169260, 149 Show/Hide	C24H26N8O3S	1
1	IC50 < 100 nM
CP0236314 Compound Info	US9169260, 57 Show/Hide	C23H24FN7O3S	1
1	IC50 < 100 nM
CP0260999 Compound Info	US9169260, 74 Show/Hide	C27H30FN7O	1
1	IC50 < 100 nM
CP0269746 Compound Info	US9169260, 16 Show/Hide	C23H25N7O4S	1
1	IC50 < 100 nM
CP0318230 Compound Info	US9169260, 198 Show/Hide	C21H23N9O	1
1	IC50 < 100 nM
CP0376643 Compound Info	US9169260, 123 Show/Hide	C22H17N7O	1
1	IC50 < 100 nM
CP0389313 Compound Info	US9169260, 170 Show/Hide	C21H23N9O3S	1
1	IC50 < 100 nM
CP0442665 Compound Info	US9169260, 133 Show/Hide	C25H22N6O3	1
1	IC50 < 100 nM
CP0453271 Compound Info	US9169260, 73 Show/Hide	C25H26FN7O3S	1
1	IC50 < 100 nM
CP0453272 Compound Info	US9169260, 270 Show/Hide	C24H28N8O	1
1	IC50 < 100 nM
CP0538264 Compound Info	US9169260, 125 Show/Hide	C22H17N7O	1
1	IC50 < 100 nM
CP0538266 Compound Info	US9169260, 7 Show/Hide	C22H23N7O	1
1	IC50 < 100 nM
CP0093351 Compound Info	US9169260, 131 Show/Hide	C24H20N6O2	1
1	IC50 < 1000 nM
CP0121370 Compound Info	US9169260, 129 Show/Hide	C23H19N7O2	1
1	IC50 < 1000 nM
CP0239209 Compound Info	US9169260, 17 Show/Hide	C23H25N7O3S	1
1	IC50 < 1000 nM
CP0241529 Compound Info	US9169260, 46 Show/Hide	C22H22N6O2	1
1	IC50 < 1000 nM
CP0269601 Compound Info	US9169260, 35 Show/Hide	C23H24N8O2	1
1	IC50 < 1000 nM
CP0269785 Compound Info	US9169260, 20 Show/Hide	C22H23N7O3S	1
1	IC50 < 1000 nM
CP0283651 Compound Info	US9169260, 31 Show/Hide	C24H25N7O2	1
1	IC50 < 1000 nM
CP0283673 Compound Info	US9169260, 94 Show/Hide	C23H24N6O	1
1	IC50 > 1000 nM
CP0456151 Compound Info	US9169260, 130 Show/Hide	C20H18N6O	1
1	IC50 < 1000 nM
CP0492034 Compound Info	US9169260, 36 Show/Hide	C23H25N7O	1
1	IC50 < 1000 nM
CP0454475 Compound Info	CHEMBL3361252 Show/Hide	C17H24N4S	1
1	Ki = 50 nM

Clinical Information about the Protein

Target 1 ( Renal carcinoma antigen NY-REN-64 (IRAK-4) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Atopic dermatitis [ICD-11: EA80]
2	Lymphoma [ICD-11: 2A80-2A86]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	Zabedosertib	Drug Info	Phase 2	Atopic dermatitis
2	CA-4948	Drug Info	Phase 1	Lymphoma

Target 2 ( IRAK4 messenger RNA (IRAK4 mRNA) )

Target Type	Literature-reported Target

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han