US9169260, 199

N-[5-(3-fluoropiperidin-1-yl)-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

N-(2-morpholin-4-yl-5-piperidin-1-yl-1,3-benzoxazol-6-yl)-6-(1H-pyrazol-4-yl)pyridine-2-carboxamide

6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)pyridine-2-carboxamide

4-[[4-(4-cyclopropylsulfonylpiperazin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

4-[[4-(4,4-difluoropiperidin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

4-[[4-(4-fluoropiperidin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

N-[5-(4-hydroxypiperidin-1-yl)-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

2-[(3S)-3-hydroxypyrrolidin-1-yl]-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-1,3-oxazole-4-carboxamide

N-[5-(4-fluoropiperidin-1-yl)-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

2-(2-methoxypyridin-4-yl)-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-1,3-oxazole-4-carboxamide

US9169260, 198

2-(2-methylpyridin-4-yl)-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-1,3-oxazole-4-carboxamide

N-[5-(3-ethyl-3-hydroxypiperidin-1-yl)-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

US9169260, 270

4-[[4-(dimethylamino)cyclohexyl]amino]quinazoline-6-carbonitrile

4-[(4-morpholin-4-ylcyclohexyl)amino]quinazoline-6-carbonitrile

4-[[4-(4-methylsulfonylpiperazin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-5-piperidin-1-yl-1,3-benzoxazol-6-yl)pyridine-2-carboxamide

4-N,4-N-dimethyl-1-N-[6-(trifluoromethyl)quinazolin-4-yl]cyclohexane-1,4-diamine

N-[5-[(3R)-3-fluoropyrrolidin-1-yl]-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

CHEMBL4068395

N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-6-(1H-pyrazol-4-yl)pyridine-2-carboxamide

6-(1-methylpyrazol-4-yl)-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)pyridine-2-carboxamide

1-N-(6-cyclopropylquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

US9169260, 74

4-[(4-pyrrolidin-1-ylcyclohexyl)amino]quinazoline-6-carbonitrile

(1R,2S,3R,5R)-3-[[2-amino-5-([1,3]thiazolo[5,4-c]pyridin-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

1-N-(6-methoxyquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

4-N,4-N-dimethyl-1-N-(6-propan-2-ylquinazolin-4-yl)cyclohexane-1,4-diamine

1-N-(6-ethylquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

4-[[4-(4-methylpiperazin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

4-N,4-N-dimethyl-1-N-(6-methylquinazolin-4-yl)cyclohexane-1,4-diamine

US9169260, 149

(1R,2S,3R,5R)-3-[[2-amino-5-([1,3]thiazolo[4,5-c]pyridin-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

N-[5-[(3S)-3-hydroxypyrrolidin-1-yl]-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

US9169260, 153

N-[5-[[4-[2-[2-[2-[2-[1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindol-5-yl]oxyethoxy]ethoxy]ethoxy]ethyl]piperazin-1-yl]methyl]-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide

N-[5-[[4-[[1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperidin-4-yl]methyl]piperazin-1-yl]methyl]-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide

N-[2-[1-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]ethoxy]ethyl]piperidin-4-yl]-6-methoxyindazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

N-[5-[[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxycyclohexyl]methyl]piperazin-1-yl]methyl]-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide

N-[5-[[4-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxyethoxy]ethoxy]ethyl]piperazin-1-yl]methyl]-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide

N-[2-[1-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]oxyethoxy]ethyl]piperidin-4-yl]-6-methoxyindazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

N-[5-[(3R)-3-hydroxypyrrolidin-1-yl]-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

4-[(4-aminocyclohexyl)amino]quinazoline-6-carbonitrile

4-[[4-(azetidin-1-yl)cyclohexyl]amino]quinazoline-6-carbonitrile

N-(3-carbamoyl-1-methylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-(3-carbamoyl-1-methyl- 1H-pyrazol-4-yl)-5- piperazin-1- ylpyrazolo[1,5- a]pyrimidine-3- carboxamide hydrochloride

US9169260, 57

6-[(3S)-3-hydroxypyrrolidin-1-yl]-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)pyridine-2-carboxamide

US9169260, 133

US9169260, 37

N-(5-cyclopropyl-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

N,N-dimethyl-4-(6-nitroquinazolin-4-yl)oxycyclohexan-1-amine

US9169260, 53

US9169260, 125

N-[5-[(3R)-3-aminopyrrolidin-1-yl]-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide

US9169260, 18

US9169260, 16

US9586948, Example 1

US9169260, 7

US9169260, 73

US9169260, 123

US9586948, Example 6

(1R,2S,3R,5R)-3-[(2-amino-5-quinolin-2-ylpyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

6-[(3S)-3-aminopyrrolidin-1-yl]-N-(2-morpholin-4-yl-5-piperidin-1-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)pyridine-2-carboxamide

US9586948, Example 29

US9586948, Example 28

US9586948, Example 18

US9169260, 36

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-chloropyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9169260, 131

US9169260, 31

US9169260, 170

US9586948, Example 3

US9586948, Example 15

US9586948, Example 46

US9586948, Example 42

US9586948, Example 12

US9169260, 35

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-6-methyl-2-(propylamino)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9586948, Example 49

US9169260, 20

US9586948, Example 19

(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-([1,3]thiazolo[5,4-c]pyridin-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

1-N-(6,7-difluoroquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

N-[5-(6-methoxypyridin-3-yl)-2-(4-methylphenyl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

US9169260, 130

US9169260, 129

6-(6-aminopyridin-3-yl)-N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)pyridine-2-carboxamide

US9586948, Example 22

(1R,2S,3R,5R)-3-[[2-amino-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9169260, 46

US9586948, Example 17

N-(5-cyclopropyl-2-morpholin-4-yl-[1,3]oxazolo[4,5-b]pyridin-6-yl)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1,3-oxazole-4-carboxamide

(1R,2S,3R,5R)-3-[[2-amino-5-([1,3]thiazolo[5,4-b]pyridin-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9586948, Example 40

US9586948, Example 2

US9586948, Example 31

N-(3-phenyl-1-p-tolyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

US9586948, Example 34

N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)-6-pyridin-3-ylpyridine-2-carboxamide

(1R,2S,3R,5R)-3-[(2-amino-5-pyridin-2-ylpyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-[(2-methylpyridin-4-yl)amino]pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-[(2,6-dimethylpyridin-4-yl)amino]pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-methylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9586948, Example 7

US9586948, Example 23

(1R,2S,3R,5R)-3-[(2-amino-5-imidazo[1,2-a]pyridin-3-ylpyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

1-N-(6,7-dimethylquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

US9586948, Example 5

N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)-6-pyridin-4-ylpyridine-2-carboxamide

US9586948, Example 43

US9586948, Example 36

US9169260, 17

US9586948, Example 37

N-(5-methyl-2-phenylpyrazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

US9169260, 94

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzoxazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

US9586948, Example 50

US9586948, Example 8

US9586948, Example 10

US9586948, Example 14

US9586948, Example 47

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2,6-diamino-5-(1,3-benzothiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-(pyrimidin-5-ylamino)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-ethylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

1-N-(6,7-dimethoxyquinazolin-4-yl)-4-N,4-N-dimethylcyclohexane-1,4-diamine

(1R,2S,3R,5R)-3-[[2-amino-5-(5-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2-amino-5-(1-methylbenzimidazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-(cyclopropylmethylamino)-6-methylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

2-amino-5-(1,3-benzothiazol-2-yl)-6-[[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino]pyrimidine-4-carbonitrile

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-(trifluoromethyl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[(2-amino-5-phenylpyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

5-(1,3-benzothiazol-2-yl)-4-methyl-6-morpholin-4-yl-N-propylpyrimidin-2-amine

(1R,2S,3R)-3-[[5-(1,3-benzothiazol-2-yl)-6-methyl-2-(propylamino)pyrimidin-4-yl]amino]cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-methoxypyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

(1R,2S,3R,5R)-3-[[2-amino-5-(1,3-benzothiazol-2-yl)-6-cyclopropylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

[(1R,3S)-3-[[5-(1,3-benzothiazol-2-yl)-6-methyl-2-(propylamino)pyrimidin-4-yl]amino]cyclopentyl]methanol

(1R,2S,3R,5R)-3-[[2-anilino-5-(1,3-benzothiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

N-[3-(benzylcarbamoyl)-1-methylpyrazol-4-yl]-6-[2-(cyclopropylmethylamino)pyridin-4-yl]pyridine-2-carboxamide

6-[2-(cyclopropylmethylamino)pyridin-4-yl]-N-[1-methyl-3-(2-methylpropylcarbamoyl)pyrazol-4-yl]pyridine-2-carboxamide

6-[2-(cyclopropylmethylamino)pyridin-4-yl]-N-[1-methyl-3-(pyridin-4-ylmethylcarbamoyl)pyrazol-4-yl]pyridine-2-carboxamide

6-[2-(cyclopropylmethylamino)pyridin-4-yl]-N-[3-(3-hydroxypyrrolidine-1-carbonyl)-1-methylpyrazol-4-yl]pyridine-2-carboxamide

N-[3-(cyclopentylcarbamoyl)-1-methylpyrazol-4-yl]-6-[2-(cyclopropylmethylamino)pyridin-4-yl]pyridine-2-carboxamide

N-(3-carbamoyl-1-methylpyrazol-4-yl)-4-[2-(cyclopropylmethylamino)pyridin-4-yl]pyridine-2-carboxamide