General Information of the Compound
Compound ID
CP0093353
Compound Name
US9169260, 18
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Structure
Formula
C23H25N7O3S
Molecular Weight
479.566
Canonical SMILES
Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O
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InChI
InChI=1S/C23H25N7O3S/c1-16-4-6-18(7-5-16)30-21(26-23(31)19-15-25-29-11-3-10-24-22(19)29)14-20(27-30)17-8-12-28(13-9-17)34(2,32)33/h3-7,10-11,14-15,17H,8-9,12-13H2,1-2H3,(H,26,31)
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InChIKey
ZZZGNHFUKUBLNW-UHFFFAOYSA-N
Physicochemical Property
logP
2.61472
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
114.49
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68328146
ChEMBL ID
CHEMBL3586498
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00821, Interleukin-1 receptor-associated kinase 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CL000864 THP1-Xblue Homo sapiens (Human)  1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 100 nM